Results 91 to 100 of about 8,258 (199)

Harnessing Aggregation‐Induced Emission for Advanced Disease Diagnosis: Mechanisms, Strategies and Future Perspectives

Medicine Bulletin, EarlyView.
The figure was created in BioRender.com. ABSTRACT Accurate and early diagnosis remains a key challenge in modern disease management. Conventional diagnostic methods often suffer from limitations in sensitivity, spatial resolution, and practical usability.
Zizhuo Du, Li Song, Xingrui Chen, Jun Jing, Yingchen Wang, Yue Jiang, Jiahui Gao, Dan Li, Feiran Xie, Peihong Xiao, Ben Zhong Tang   +10 more
wiley   +1 more source

Engineering psychrophilic polymerase for nanopore long-read sequencing

Frontiers in Bioengineering and Biotechnology
Unveiling the potential application of psychrophilic polymerases as candidates for polymerase-nanopore long-read sequencing presents a departure from conventional choices such as thermophilic Bacillus stearothermophilus (Bst) renowned for its limitation ...
Yaping Sun, Danny Hsu Ko, Jie Gao, Kang Fu, Yuanchen Mao, Yun He, Hui Tian   +6 more
doaj   +1 more source

The enzymatic basis of processivity in l exonuclease

, 2003
l Exonuclease is a highly processive 5¢®3 ¢ exo-nuclease that degrades double-stranded (ds)DNA. The single-stranded DNA produced by l exo-nuclease is utilized by homologous pairing proteins to carry out homologous recombination.
Walter Scott, Richard S. Myers, Wiriya Rutvisuttinunt, Krithika Subramanian   +3 more
core  

Switching between polymerase and exonuclease sites in DNA polymerase ε

, 2014
The balance between exonuclease and polymerase activities promotes DNA synthesis over degradation when nucleotides are correctly added to the new strand by replicative B-family polymerases. Misincorporations shift the balance toward the exonuclease site,
Erik Johansson, Johansson, Erik,, Göran O. Bylund, Bylund, Göran,, Ganai, Rais Ahmad, Bylund, Göran, Johansson, Erik, Ganai, Rais Ahmad,, Rais A. Ganai   +8 more
core   +1 more source

Near‐T2T genome assembly of Erigeron sumatrensis provides insights into polyploid evolution and the herbicidal efficiency of HPPD inhibitors

New Plant Protection, EarlyView.
The near‐T2T genome assembly of Erigeron sumatrensis reveals an allohexaploid origin, evolution, and the interaction between the herbicidal target of the HPPD family and mesotrione. Abstract Species of Erigeron, members of the family Asteraceae, have invaded and adapted to agricultural fields and uncultivated habitats worldwide. Erigeron sumatrensis is
Yingying Wang, Jian Zhao, Jiao Zhang, Yaliang Shi, Xin Zhang, Feng Luo, Lianyang Bai, Meiliang Zhou, Zuren Li   +8 more
wiley   +1 more source

Additional file 3 of Recommendations for the classification of germline variants in the exonuclease domain of POLE and POLD1

Additional file 3: Table S3. Characteristics and classification of constitutional (germline) POLE and POLD1 exonuclease domain missense variants.Agencia Estatal de Investigación; Instituto de Salud Carlos III; Agència de Gestió d'Ajuts Universitaris i de
Valle, Laura, Capellá, Gabriel, Viana-Errasti, Julen, Feliubadaló, Lidia, Pineda, Marta, Magraner-Pardo, Lorena, Muñoz, Inés G., Pons, Tirso, García-Mulero, Sandra, Mur, Pilar   +9 more
core   +1 more source

Dedifferentiation in endometrial cancer is associated with HLA‐I silencing that may be restored by IFN‐γ

The Journal of Pathology, EarlyView.
Abstract Dedifferentiated endometrial carcinoma occurs when a prognostically favorable low‐grade endometrial carcinoma transforms into a highly aggressive undifferentiated carcinoma following genomic inactivation of core SWItch/Sucrose Non‐Fermentable (SWI/SNF) complex protein(s).
Antonio De Leo, Madison Wickenberg, Marco Grillini, Camelia Alexandra Coadǎ, Pooja Praveen Kumar, Annie Tong, James Key, Hannah Kim, Felix Kommoss, Mark Carey, Yangxin Fu, Claudio Ceccarelli, Giovanni Tallini, Paul LaPointe, Martin Köbel, Cheng‐Han Lee   +15 more
wiley   +1 more source

Carbon dots in electrochemiluminescence: Mechanisms, interface engineering, and bioanalytical applications

Responsive Materials, EarlyView.
Carbon dots are emerging as versatile electrochemiluminescent nanomaterials whose structure, surface states, and interfacial design jointly determine ECL pathways and performance. This review highlights how mechanistic understanding and materials engineering enable programmable CD‐ECL systems for bioanalysis, imaging, and future intelligent analytical ...
Yuhan Zhao, Zixuan Chen, Jun‐Jie Zhu
wiley   +1 more source

A single-strand DNA binding endo-exonuclease of Neurospora crass /

, 1981
Employing successive chromatography on DEAE-Sepharose and on single-strand (ss) DNA-cellulose, a new form of Neurospora endo-exonuclease has been isolated, a Mg('2+)-dependent ss-DNA-binding endo-exonuclease.
Chow, Terry Yui-Kwong
core  

Programmable Assembly of Higher‐Order DNA Nanostructures from Microbial ssDNA Staple Libraries

Small, EarlyView.
A phage‐free, microbial platform produces programmable circular ssDNA libraries that are enzymatically converted into DNA origami staple pools. Rolling‐circle replication generates sequence‐complex ssDNA with >99% fidelity, enabling assembly of DNA tiles and tubules and supporting nanostructure formation even in crude cellular lysates.
Ming Hung Yen, Mallikarjuna Reddy Kesama, Yancheng Du, Jong Hyun Choi, Kevin V. Solomon   +4 more
wiley   +1 more source