Results 81 to 90 of about 8,258 (199)
The importance of gene polymorphism in familial inheritance of endometriosis
International Journal of Gynecology &Obstetrics, EarlyView.Abstract Objective The study aimed to investigate familial transmission patterns in women with endometriosis by generating a customized single‐nucleotide polymorphism (SNP) array. Methods Patients aged 18–45 who were diagnosed histopathologically with endometriosis were included in the study.
Hale Goksever Celik +4 more
wiley +1 more source
BIOCHEMICAL, STRUCTURAL, & COMPUTATIONAL STUDIES OF TREX1 EXONUCLEASE ACTIVITY
, 2021 The 3’ -> 5’ exonuclease TREX1 functions in vivo to degrade DNA and prevent stimulation of the DNA-sensing pathway cGAS-STING, which would otherwise instigate a spectrum of harsh autoimmune phenotypes.
Hemphill, Wayne O
core +1 more source
Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials
iNew Medicine, EarlyView.ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong +5 more
wiley +1 more source
SbcB facilitates natural transformation in Vibrio cholerae in an exonuclease-independent manner
Journal of BacteriologyNatural transformation (NT) is a conserved mechanism of horizontal gene transfer in bacterial species. During this process, DNA is taken up into the cytoplasm where it can be integrated into the host genome by homologous recombination. We have previously
Triana N. Dalia, Ankur B. Dalia
doaj +1 more source
Exonuclease IX of Escherichia coli
, 1998 The bacteria Escherichia coli contains several exo-nucleases acting on both double- and single-stranded DNA and in both a 5′→3 ′ and 3′→5 ′ direction. These enzymes are involved in replicative, repair and recombination functions. We have identified a new
William A. Franklin +2 more
core
Enhanced CRISPR‐cas systems for genome editing and molecular diagnostics
Interdisciplinary Medicine, EarlyView.This review systematically summarizes the major optimization strategies for CRISPR‐Cas systems, focusing on the engineering of Cas proteins, guide RNAs, reporter probes, and the incorporation of chemical additives. The aim is to enhance editing precision and diagnostic capability, thereby expanding the CRISPR system's potential for broader biomedical ...
Sheng Li +7 more
wiley +1 more source
Genetics and Molecular BiologyApurinic/apyrimidinic sites are one of the most frequent spontaneous lesions in DNA. Evolutionarily conserved AP endonucleases (ExoIII and EndoIV families) incise the DNA backbone 5′ to the AP site and the cleaved AP sites are subsequently repaired by ...
Seoyun Choi, Hoa Thi Pham, Byungchan Ahn
doaj +1 more source
Journal of Clinical Laboratory Analysis, EarlyView.This study developed an optimized multiplex RT‐MIRA assay for the simultaneous detection of EML4‐ALK variants, achieving single‐copy sensitivity. Unexpectedly, during the development of the reaction system, we discovered a “low‐concentration enhancement effect,” where reducing primer or probe concentrations within a specific range markedly improved ...
Xiao‐Dong Ren +10 more
wiley +1 more source
BMC Plant BiologyCRISPR/Cas technologies have revolutionized plant genome editing, yet their inherent bias toward small insertions or deletions (indels) limits their utility for dissecting regulatory elements and generating impactful allelic variants. Here, we report the
Vikas Devkar +3 more
doaj +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation and progressive joint damage. Although ferroptosis has been implicated in RA progression, the role of disulfidptosis and its interaction with ferroptosis remains unclear.
Ting‐Ting Wang +10 more
wiley +1 more source