Results 121 to 130 of about 8,258 (199)
The FEBS Journal, EarlyView.Seq‐Scope maps skeletal muscle transcriptomes at high spatial resolution while preserving histological context, revealing distinct responses of myofibers, neuromuscular junctions, and stromal cells to denervation. This spatial view uncovers fiber type‐specific and localized remodeling across intact muscle tissue.
Jer‐En Hsu +16 more
wiley +1 more source
PLoS ONEFor in vitro DNA assembly, enzymes with exonuclease activities have been utilized to generate relatively long recessed ends on DNA fragments, which can anneal to other DNA fragments if they have complementary nucleotide sequences.
Seoee Lee +5 more
doaj +1 more source
A guide to transcriptional cyclin‐dependent kinases in cancer
The FEBS Journal, EarlyView.Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin +2 more
wiley +1 more source
Escherichia coli exonuclease III enhances long PCR amplification of damaged DNA templates
, 2000 International audienceRecent development of the long PCR technology has provided an invaluable tool in many areas of molecular biology. However, long PCR amplification fails whenever the DNA template is imperfectly preserved.
Pessayre, D +3 more
core +1 more source
International Journal of Immunogenetics, EarlyView.ABSTRACT Genetic factors that modulate immune regulation are increasingly recognised as contributors to the heterogeneity and clinical course of autoimmune diseases. Polymorphisms of protein tyrosine phosphatase non‐receptor type 22 (PTPN22) are associated with several autoimmune diseases.
Sonja Kvist +5 more
wiley +1 more source
Journal of Animal Physiology and Animal Nutrition, EarlyView.ABSTRACT The transition from immature pullets to sexually mature female chickens is accompanied by pronounced structural and functional modifications. This is accompanied by coordinated changes in hormonal and metabolic pathways that primarily regulate reproduction, nutrient utilization, and mineral homeostasis to compensate for temporary imbalances ...
Henry Reyer +6 more
wiley +1 more source
Chromatin Remodelling Complexes in Plant Adaptation to Abiotic Stress: Mechanisms and Perspectives
Plant, Cell &Environment, EarlyView.ABSTRACT As sessile organisms, plants have evolved elaborate epigenetic regulatory networks to adapt to a wide range of abiotic stress. Chromatin remodelling is a core epigenetic regulatory mechanism that refers to the process by which chromatin remodelling complexes mediate dynamic changes in chromatin spatial conformation and DNA accessibility ...
Xiuxiu Zhang, Yueran Zhang, Jiang Li
wiley +1 more source
Analytical Science Advances, Volume 7, Issue 2, December 2026.Forty circular RNAs were found to be significantly dysregulated in microarray datasets. Expression levels of hsa_circ_0000231 were significantly upregulated in breast cancer (BC) tissues, while hsa_circ_0011385 exhibited no significant difference in expression levels. This study also revealed that hsa_circ_0000231/hsa‐miR‐5683/CCNB1 regulatory axis may
MohamadReza Hashemi +4 more
wiley +1 more source
International Journal of Cancer, Volume 159, Issue 8, Page 1857-1872, 15 October 2026.ABSTRACT Clinical trials combining radiotherapy (RT) with immune checkpoint blockade (ICB) have shown improved outcomes in only a fraction of patients, and optimal strategies for integrating these modalities remain under intense investigation. With a few exceptions, phase III combination trials have yielded disappointing results.
Xuanwei Zhang +10 more
wiley +1 more source
International Journal of Cancer, Volume 159, Issue 8, Page 1873-1883, 15 October 2026.ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers due to its asymptomatic progression, late‐stage diagnosis, and treatment resistance. Efforts in early detection have centered on identifying imaging features and liquid biopsy biomarkers capable of detecting PDAC and its high‐grade precursors before clinical symptoms ...
Christine Worthington +105 more
wiley +1 more source