Results 131 to 140 of about 8,258 (199)
SINE Insertion in LAMA3 in Dogs With Junctional Epidermolysis Bullosa
Animal Genetics, Volume 57, Issue 5, October 2026.ABSTRACT Junctional epidermolysis bullosa (JEB) is a hereditary skin disorder caused by defects in proteins responsible for dermal‐epidermal adhesion. We investigated the genetic cause of JEB in three related mixed‐breed puppies presenting with congenital skin blistering and ulceration. Whole‐genome sequencing of one affected dog followed by comparison
Sarah Kiener +4 more
wiley +1 more source
ABCB1 Frameshift Deletion in Skye Terriers With Potential Pharmacogenetic Relevance
Animal Genetics, Volume 57, Issue 5, October 2026.ABSTRACT Ivermectin‐associated neurotoxicity is a potentially life‐threatening condition caused by disruption of the ABCB1 encoded P‐glycoprotein drug transporter in certain dog breeds. Skye terriers are considered at increased risk of ivermectin toxicity despite the absence of an identified molecular cause.
Monica Nielsen +4 more
wiley +1 more source
MicrobiologyOpen, Volume 15, Issue 5, October 2026.Two novel lytic Enterobacter phages, HHH and RZH, displayed targeted antibiofilm activity against MDR Enterobacter cloacae complex biofilms when combined with EDTA. Activity was strongest within a narrow low‐millimolar EDTA window, reducing biofilm biomass and viable burden, while higher EDTA concentrations shifted the interaction towards antagonism ...
Kashif Haq +4 more
wiley +1 more source
The Journal of Pathology, Volume 270, Issue 2, Page 139-162, October 2026.Abstract Prostate cancer (PCa) is the second most common type of neoplasm, currently treated with a variety of therapeutic agents. Although advances in treatment over the past decade have improved overall survival, patients with advanced PCa eventually progress from hormone‐sensitive PCa to metastatic castration‐resistant PCa.
Giuseppe Schepisi +8 more
wiley +1 more source
Genomic and Phenotypic Classification of Staphylococcus Species Isolated From Delhi Air
Environmental Microbiology Reports, Volume 18, Issue 5, October 2026.Multiple Staphylococcus spp. were isolated from the outdoor polluted air of the Indian Capital, New Delhi. The bacterial samples were collected from 6 different locations, and the whole genome of four Staphylococcus isolates was sequenced in their entirety. This study presents the comparative genomic analysis of these four isolates.
Himanshu Sen +8 more
wiley +1 more source
RNA‐Guided Engineering of the Chloroplast Genome Enabled by Plastid‐Expressed Guide RNAs
Plant Biotechnology Journal, Volume 24, Issue 10, Page 5498-5509, October 2026.ABSTRACT Our goal is to develop RNA‐guided engineering of the chloroplast genome using the CRISPR/Cas9 system. We designed chloroplast minigenes to obtain properly sized single guide RNAs (sgRNAs) in tobacco chloroplasts. The sgRNA 5′ end is defined by transcription from an rRNA operon promoter, and its 3′ end by processing a downstream tRNA (trnG) or ...
Malihe Mirzaee +3 more
wiley +1 more source
Circular Photocaged mRNA for Light‐induced Late‐stage Activation of Translation
Angewandte Chemie International Edition, Volume 65, Issue 39, 21 September 2026.A clickable photo‐caged 5′ cap (CyCliCap) allows to make Cyclic Click Cap‐containing mRNA (CyCliCap‐mRNA) which is remarkably stable and translationally muted until irradiated, allowing for late‐stage activation of translation in cells by light. ABSTRACT mRNA is a new medical modality as vaccine and raises hopes to become a protein replacement agent ...
Bayram Terzi +6 more
wiley +1 more source
Nucleic Acids as Emerging Regulators of Calcium Phosphate Biomineralization
The FASEB Journal, Volume 40, Issue 17, 15 September 2026.Calcium phosphate biomineralization has traditionally been considered a protein‐regulated process. This review highlights the emerging role of nucleic acids, which interact with mineral phases through adsorption, coprecipitation, and templating, thereby influencing crystal nucleation and growth.
Fanny Duhalde +2 more
wiley +1 more source
Construction of recombinant DNA by exonuclease recession
, 1993 We describe a new exonuclease-based method for joining and/or constructing two or more DNA molecules. DNA fragments containing ends complementary to those of a vector or another independent molecules were generated by the polymerase chain reaction. The 3
William J. Watson +3 more
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Expression of Active Apurinic Apyrimidinic Endodeoxyribonuclease 1 in Human Platelets
The FASEB Journal, Volume 40, Issue 17, 15 September 2026.Platelets (PLTs) isolated from healthy donors contain variable amounts of enzymatically active APE1, likely surveilling mitochondrial DNA integrity and overall mitochondria functioning. The use of the specific APE1 inhibitor compound #3 on platelet rich plasma (PRP) significantly impairs the PLTs' aggregation properties of activated PLTs triggered only
Isabella Parolini +9 more
wiley +1 more source