Results 151 to 160 of about 8,258 (199)
The Significance of cGAS‐STING Signaling in Response to Oncogenic Viruses
Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.ABSTRACT The cyclic GMP‐AMP synthase (cGAS)‐stimulator of interferon genes (STING) signaling pathway, as a key DNA sensor, plays a significant role in the regulation of innate immune responses. This pathway can be activated by sensing abnormal DNA, and is of great significance for resisting the invasion of pathogenic microorganisms and maintaining ...
Limei Guo +4 more
wiley +1 more source
Cancer Reports, Volume 9, Issue 9, September 2026.ABSTRACT Background Hepatoid adenocarcinoma of the lung (HAL) is a rare form of lung cancer with histological and morphological properties of hepatocellular carcinoma, characterized by an aggressive course of the disease and unfavorable prognosis. Given the rarity of the pathology and the lack of unambiguous therapeutic protocols, descriptions of ...
Aleksey Chernev +8 more
wiley +1 more source
Clinical Pharmacology in Drug Development, Volume 15, Issue 9, September 2026.Abstract Increased activity in the complement alternative pathway (AP) plays a key role in diseases such as IgA nephropathy (IgAN). This first‐in‐Japanese double‐blind Phase 1 study investigated the pharmacokinetics (PK), pharmacodynamics (PD), safety, and tolerability of sefaxersen (RO7434656), an antisense oligonucleotide targeting complement factor ...
Takakazu Sato +3 more
wiley +1 more source
Ecology and Evolution, Volume 16, Issue 9, September 2026.Clear genetic and morphological divergence were revealed between the two Korean endemic 'putative' species Rhynchocypris kumgangensis and the Deogyu population (R. deogyuensis) using an integrated analysis of molecular markers, mitogenomes, and geometric and morphometrics on body shape.
Soon Young Hwang +3 more
wiley +1 more source
Evolutionary Reorganization of Transcriptomic Architecture Across a UVB Tolerance Gradient in Fish
Ecology and Evolution, Volume 16, Issue 9, September 2026.Environmental stress can drive adaptation through changes in transcriptomic organization. Across a UVB tolerance gradient in fish, adaptive responses were associated with increasingly coordinated and functionally specialized transcriptomic networks built upon a conserved functional background.
Camilo Valdivieso, Miguel Luis Allende
wiley +1 more source
Using DNA Metabarcoding and Citizen Science to Assess the Diet of Owned Domestic Cats
Ecology and Evolution, Volume 16, Issue 9, September 2026.ABSTRACT Various methods have been attempted to quantify hunting and consumption of wild prey by domestic cats, but molecular analysis of their scat using DNA metabarcoding has rarely been attempted. In this study, we relied on owner‐collected scats (n = 32) from litterboxes and backyards to test whether this methodology could be used to detect ...
Hee Jin Chung +2 more
wiley +1 more source
Environmental DNA, Volume 8, Issue 5, September‐October 2026.Small and well camouflaged fish are difficult to monitor, but they do release DNA into the water (1). These assays allow for targeted monitoring of two European seahorses of conservation concern, using two primers and probe pairs with high specificity (2) and proven detections from the field (3).
Ellen Vaughan +3 more
wiley +1 more source
Immunity, Inflammation and Disease, Volume 14, Issue 9, September 2026.Messenger RNA therapeutics are rapidly expanding beyond infectious diseases into oncology, autoimmune disorders, protein replacement therapy, cardiovascular and neurological diseases, and regenerative medicine. Advances in RNA engineering and targeted delivery are driving the development of safe, programmable, and precision therapeutics for diverse ...
Gedion Mengistu Dejen
wiley +1 more source
Strategies and mechanisms of precision genome engineering: From gene editing to genome writing
iMetaOmics, Volume 3, Issue 3, September 2026.In this review, we examined the progression of genome manipulation from stochastic nuclease‐mediated cutting toward precise editing and programmable genome writing. We discussed tools like multi‐kilobase RNA‐guided integrators and Artificial Intelligence (AI)‐designed effectors and showed how these advances enable researchers to treat genomes as ...
Kerui Huang +19 more
wiley +1 more source
Interdisciplinary Medicine, Volume 4, Issue 5, September 2026.Inspired by the role of Mg2+ in stabilizing RNA secondary structures, we developed a one‐pot biomimetic mineralization method for synthesizing a circular RNA‐based nanovaccine (circRNA@FAiNVac) that integrates formulation and adjuvant functions. This nanovaccine exhibits potent immunostimulatory activation enabling multimodal immune responses and ...
Liangru Lin +10 more
wiley +1 more source