Results 171 to 180 of about 8,258 (199)

Engineering the Electrochemiluminescence Microenvironment: Mechanistic Roles of Nanomaterials in Aptamer‐Based Sensors

Small Structures, Volume 7, Issue 9, September 2026.
This review highlights how nanomaterials have transformed electrochemiluminescence (ECL) aptasensors beyond their traditional role as supports. It examines their emerging roles as new ECL luminophores and active regulators of the ECL microenvironment within aptasensors.
Ana Díaz‐Fernández, Noemí de‐los‐Santos‐Álvarez, María Jesús Lobo‐Castañón   +2 more
wiley   +1 more source

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, Volume 81, Issue 9, Page 3039-3070, September 2026.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
Franziska Roth‐Walter, Ian M. Adcock, Cristina Benito‐Villalvilla, Rodolfo Bianchini, Leif Bjermer, Gaetano Caramori, Luigi Cari, Kian Fan Chung, Zuzana Diamant, Ibon Eguiluz‐Gracia, Edward F. Knol, Milos Jesenak, Francesca Levi‐Schaffer, Giuseppe Nocentini, Liam O'Mahony, Oscar Palomares, Frank Redegeld, Milena Sokolowska, Betty Van Esch, Marco Zurlo, Cristiana Stellato   +20 more
wiley   +1 more source

circMAN1A2 as an Isoform‐Resolved Circular RNA Hub in Cancer

Cancer Science, Volume 117, Issue 9, Page 2345-2356, September 2026.
circMAN1A2 as an isoform‐resolved circular RNA hub in cancer. circMAN1A2 is generated by back‐splicing of MAN1A2 pre‐mRNA, with alternative circularization producing multiple isoforms, including the predominant circMAN1A2(2–5). Its mechanistic interfaces include miRNA‐associated regulation, RBP binding/proteostasis control, BSJ‐mediated RNA–RNA pairing,
Hanyu Shang, Hui Wang, Yonghang Xu, Lingyun Geng, Yanqing Wang   +4 more
wiley   +1 more source

Coupling of both a transactivation module and a double‐stranded DNA‐binding domain boosts Cas12i3 variant‐based cytosine and adenine editing in plants

Journal of Integrative Plant Biology, Volume 68, Issue 9, Page 3196-3207, September 2026.
Fusions of a transactivation module and a double‐stranded DNA‐binding domain produced effective Cas12i3 variant‐based cytosine and adenine base editors, with improved C‐to‐T and A‐to‐G base editing efficiency and expanded editing window. Generated herbicide‐resistant rice germplasm by using these base editors demonstrates their potential for precise ...
Chen Zhang, Jingying Li, Yucai Li, Lei Yan, Christina Seok Yien Yong, Shaoya Li, Yubing He, Lanqin Xia   +7 more
wiley   +1 more source

Enhanced exonuclease–Cas9 systems promote multiple nucleotide deletions with higher efficiency and broader targeting scope in plants

Journal of Integrative Plant Biology, Volume 68, Issue 9, Page 3316-3328, September 2026.
Cas9 preferentially generates small indels. By tethering an exonuclease and a DNA‐binding domain (DBD) to Cas9, the Exo‐DBD‐Cas9 system efficiently promotes multiple nucleotide deletions. These expanded deletions enable effective disruption of miRNA‐mediated regulation and relieve translational repression through targeted editing of 3′ untranslated ...
Rui Zhang, Xu Tang, Yao He, Wei Wang, Qiurong Ren, Yiping Qi, Yong Zhang   +6 more
wiley   +1 more source

Synergistic engineering of Casδ nuclease for robust genome editing

Journal of Integrative Plant Biology, Volume 68, Issue 9, Page 3231-3242, September 2026.
A hierarchical engineering strategy was used to enhance the editing activity of Casδ, yielding an optimized variant termed enCasδ. This variant enables robust genome editing in animal cells and plants, with overall editing performance comparable to that of SpCas9 and other Cas12 nucleases.
Fanghui Ge, Chenchen Peng, Yang Du, Ying Chen, Zilong Zhao, Meixia Yu, Huairu Feng, Yuyang Xie, Siwei Sun, Shengnan Liu, Beibei Xin, Haiming Zhao, Sen Wu, Chao Bian, Zhijia Yang, Jinsheng Lai, Jian Chen   +16 more
wiley   +1 more source

Optimized Cas‐SF01 gene‐editing toolbox shortens flowering timing in commercial maize inbred JING724

Journal of Integrative Plant Biology, Volume 68, Issue 9, Page 3178-3180, September 2026.
The gene‐editing tool Cas‐SF01 was optimized to maximize its efficiency in maize. The Cas‐SF01‐TREX2 configuration was superior in enabling high‐purity gene mutations. This toolkit enabled commercial maize to flower seven days earlier without yield loss, thereby securing harvests and accelerating crop breeding.
Mengyuan Liu, Yao Wang, Lu Zhang, Xiang Zhang, Xiaqing Wang, Xinxiang Liu, Yue Fu, Xiaoxu Li, Ziheng Song, Ya Liu, Ronghuan Wang, Jiuran Zhao   +11 more
wiley   +1 more source

Cucurbit Leaf Crumple Virus: An Important Pathogen of Cucurbit and Snap Bean Crops

Molecular Plant Pathology, Volume 27, Issue 9, September 2026.
Cucurbit leaf crumple virus (CuLCrV) is an emerging pathogen in the New World. High whitefly abundance and transmission efficiency, mixed infections, weed reservoirs and limited host resistance challenge cucurbit and snap bean production. ABSTRACT Taxonomy Cucurbit leaf crumple virus (CuLCrV); Begomovirus cucurbitae; Geminiviridae; Geplafuvirales ...
Dalvir Kaur Dhadly, Saritha Raman Kavalappara, Sudeep Bag, Theodore McAvoy, Paul M. Severns, Rajagopalbabu Srinivasan, Alvin M. Simmons   +6 more
wiley   +1 more source

Writing Big in Plant Genomes: Advances, Challenges and Strategies for Targeted Large‐Fragment DNA Insertion

Plant, Cell &Environment, Volume 49, Issue 9, Page 6506-6520, September 2026.
ABSTRACT Precise genome editing has transformed plant biology and crop improvement by enabling targeted modification of endogenous loci. Beyond gene knockout and base editing, the site‐specific insertion of exogenous DNA, particularly large DNA fragments, has become a central goal for engineering complex traits, reconstructing metabolic pathways and ...
Fengfeng Zhang, Daqi Yan, Jiayi Hou, Dan Yang, Yan Xiong, Mingzhang Wen, Xiaoyue Zhu   +6 more
wiley   +1 more source

Persistent Epigenetic Reprogramming Is Associated With Contrasting Drought‐Response Strategies in Citrus Scion–Rootstock Systems

Physiologia Plantarum, Volume 178, Issue 5, September/October 2026.
ABSTRACT Recurrent drought limits the productivity of perennial crops such as citrus, whose tolerance to water deficit largely depends on scion–rootstock interactions. Although physiological responses to recurrent drought are well documented, the epigenetic states associated with these responses remain poorly understood, limiting the use of epigenetic ...
Monique Ayala Araújo da Silva, Fredson dos Santos Menezes, Iris Sammarco, Lucas da Silva Costa, Claudia Fortes Ferreira, Soares Filho, Fabienne Micheli, Maurício Antônio Coelho‐Filho, Abelmon da Silva Gesteira   +8 more
wiley   +1 more source