Results 21 to 30 of about 8,258 (199)

Characterization of Vibrio cholerae’s Extracellular Nuclease Xds

Frontiers in Microbiology, 2019
The Gram-negative bacterium Vibrio cholerae encodes two nucleases, Dns and Xds, which play a major role during the human pathogen’s lifecycle. Dns and Xds control three-dimensional biofilm formation and bacterial detachment from biofilms via degradation ...
Katharina Pressler, Fabian Mitterer, Dina Vorkapic, Joachim Reidl, Joachim Reidl, Monika Oberer, Monika Oberer, Stefan Schild, Stefan Schild   +8 more
doaj   +1 more source

The terminal redundant regions of bacteriophage T7 DNA: their necessity for phage production studied by the infectivity of T7 DNA after modification by various exonucleases [PDF]

, 1978
Dreiseikelmann B, Wackernagel W. The terminal redundant regions of bacteriophage T7 DNA: their necessity for phage production studied by the infectivity of T7 DNA after modification by various exonucleases. Molecular and General Genetics. 1978;159(3):321-
Dreiseikelmann, Brigitte, Wackernagel, Wilfried   +1 more
core   +1 more source

The Drosophila prage Gene, Required for Maternal Transcript Destabilization in Embryos, Encodes a Predicted RNA Exonuclease

G3: Genes, Genomes, Genetics, 2016
Egg activation, the transition of mature oocytes into developing embryos, is critical for the initiation of embryogenesis. This process is characterized by resumption of meiosis, changes in the egg’s coverings and by alterations in the transcriptome and ...
Jun Cui, Yun Wei Lai, Caroline V. Sartain, Rebecca M. Zuckerman, Mariana F. Wolfner   +4 more
doaj   +1 more source

Exogenous Expression of Exonuclease Domain-deleted WRN Interferes with the Repair of Radiation-induced DNA Damages [PDF]

, 2005
Werner syndrome (WS) is an autosomal recessive disease characterized by multiple progeroid features. The gene responsible for WS, WRN, is a member of the human RecQ helicase family. WRN is unique among this family, associated with an exonuclease activity.
Seiji KODAMA, Suzuki, Keiji, Masami WATANABE, Genro KASHINO, Keiji SUZUKI, Takehisa MATSUMOTO, Kodama, Seiji, Kashino, Genro, Matsumoto, Takehisa, Watanabe, Masami   +9 more
core   +1 more source

Recommendations for the classification of germline variants in the exonuclease domain of POLE and POLD1 [PDF]

, 2023
BackgroundGermline variants affecting the proofreading activity of polymerases epsilon and delta cause a hereditary cancer and adenomatous polyposis syndrome characterized by tumors with a high mutational burden and a specific mutational spectrum.
Gabriel Capellá, Julen Viana-Errasti, Capellá, Gabriel, Lidia Feliubadaló, Viana Errasti, Julen, Viana-Errasti, Julen, Marta Pineda, Sandra García-Mulero, Magraner-Pardo, Lorena, Inés G. Muñoz, Laura Valle, Mur, Pilar, García Mulero, Sandra, Valle, Laura, Pilar Mur, Feliubadaló, Lidia, Pineda, Marta, Lorena Magraner-Pardo, Muñoz, Inés G., Tirso Pons, Pons, Tirso, Magraner Pardo, Lorena, García-Mulero, Sandra   +22 more
core   +1 more source

Attacked from All Sides: RNA Decay in Antiviral Defense

Viruses, 2017
The innate immune system has evolved a number of sensors that recognize viral RNA (vRNA) to restrict infection, yet the full spectrum of host-encoded RNA binding proteins that target these foreign RNAs is still unknown.
Jerome M. Molleston, Sara Cherry
doaj   +1 more source

The gp44 Ejection Protein of Staphylococcus aureus Bacteriophage 80α Binds to the Ends of the Genome and Protects It from Degradation

Viruses, 2020
Bacteriophage 80α is a representative of a class of temperate phages that infect Staphylococcus aureus and other Gram-positive bacteria. Many of these phages carry genes encoding toxins and other virulence factors.
Keith A Manning, Terje Dokland
doaj   +1 more source

Human Mitochondrial DNA Polymerase Metal Dependent UV Lesion Bypassing Ability

Frontiers in Molecular Biosciences, 2022
Human mitochondrial DNA contains more UV-induced lesions than the nuclear DNA due to lack of mechanism to remove bulky photoproducts. Human DNA polymerase gamma (Pol γ) is the sole DNA replicase in mitochondria, which contains a polymerase (pol) and an ...
Joon Park, Joon Park, Noe Baruch-Torres, Shigenori Iwai, Geoffrey K. Herrmann, Geoffrey K. Herrmann, Luis G. Brieba, Y. Whitney Yin, Y. Whitney Yin   +8 more
doaj   +1 more source

DmWRNexo is a 3'aEuro"5' exonuclease : phenotypic and biochemical characterization of mutants of the Drosophila orthologue of human WRN exonuclease

, 2009
The premature human ageing Werner's syndrome is caused by loss or mutation of the WRN helicase/exonuclease. We have recently identified the orthologue of the WRN exonuclease in flies, DmWRNexo, encoded by the CG7670 locus, and showed very high levels of ...
Boubriak, Ivan, Mason, Penelope A., Dockray, Joel, Saunders, Robert D. C., Clancy, David J., Cox, Lynne S.   +5 more
core   +5 more sources

Single-molecule studies of exonuclease proteins

, 2021
DNA replication and maintenance are an integral part of the continued survival of all life on this planet. Therefore, the collection of proteins and the mechanisms they employ to maintain and copy DNA in the presence of continuous damage experienced from
Ryan Edward Muir (20168301)
core   +1 more source