Results 181 to 190 of about 12,706 (198)

The 3′–5′ exonucleases

Nature Reviews Molecular Cell Biology, 2002
Over the past few years, several new 3' 5' exonucleases have been identified. In vitro studies of these enzymes have uncovered much about their potential functions in vivo, and certain organisms with a defect in 3' 5' exonucleases have an increased ...
Ulrich Hubscher, Igor V Shevelev
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The role of DNA exonucleases in protecting genome stability and their impact on ageing [PDF]

Age, 2011
Exonucleases are key enzymes involved in many aspects of cellular metabolism and maintenance and are essential to genome stability, acting to cleave DNA from free ends. Exonucleases can act as proofreaders during DNA polymerisation in DNA replication, to
Lynne S Cox
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Identification of Inhibitors for the DEDDh Family of Exonucleases and a Unique Inhibition Mechanism by Crystal Structure Analysis of CRN-4 Bound with 2-Morpholin-4-ylethanesulfonate (MES)

Journal of Medicinal Chemistry, 2016
The DEDDh family of exonucleases plays essential roles in DNA and RNA metabolism in all kingdoms of life. Several viral and human DEDDh exonucleases can serve as antiviral drug targets due to their critical roles in virus replication.
Hanna S Yuan, Jinn-Moon Yang, Kai-Cheng Hsu   +2 more
exaly   +2 more sources

Exonucleases

Current Protocols in Molecular Biology, 2011
Nicole M Nichols
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Structural and biochemical studies of TREX1 inhibition by metals. Identification of a new active histidine conserved in DEDDh exonucleases

Protein Science, 2008
TREX1 is the major exonuclease in mammalian cells, exhibiting the highest level of activity with a 3′→5′ activity. This exonuclease is responsible in humans for Aicardi-Goutières syndrome and for an autosomal dominant retinal vasculopathy with cerebral ...
Jorge Lloberas, Ignacio Fita, Antonio Celada   +2 more
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Exonucleases

Current Protocols in Molecular Biology, 1987
Stanley Tabor, S Tabor
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Lysosomal endonuclease RNase T2 and PLD exonucleases cooperatively generate RNA ligands for TLR7 activation [PDF]

Immunity
Toll-like receptor 7 (TLR7) is essential for recognition of RNA viruses and initiation of antiviral immunity. TLR7 contains two ligand-binding pockets that recognize different RNA degradation products: pocket 1 recognizes guanosine, while pocket 2 ...
Veit Hornung
exaly   +2 more sources

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Manganese-dependent microRNA trimming by 3′→5′ exonucleases generates 14-nucleotide or shorter tiny RNAs

Proceedings of the National Academy of Sciences of the United States of America, 2022
Huaqun Zhang, Nipun Malhotra, GeunYoung Sim   +2 more
exaly  

PML and PML-like exonucleases restrict retrotransposons in jawed vertebrates

Nucleic Acids Research, 2023
David N Langelaan, Graham Dellaire, Shelby Williams   +2 more
exaly  

Enzymatic toxicogenation of “Activated” cyclophosphamide by 3′–5′ exonucleases

Journal of Cancer Research and Clinical Oncology, 1983
H J Hohorst, G Voelcker
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