Results 161 to 170 of about 18,119 (268)

Termination of DNA replication drives genomic instability via multiple mechanisms. [PDF]

Nucleic Acids Res
Goodall DJ, Dimude JU, Hashemloo MA, Dunbar EL, Grigoryan I, Upton AL, Bolt EL, Rudolph CJ.   +7 more
europepmc   +1 more source

Discovery of 4‐Quinazolinone‐Containing Phenylalanine Derivatives as Potent, Resistant‐Tolerant HIV Capsid Inhibitors

MedComm, Volume 7, Issue 5, May 2026.
Novel phenylalanine derivatives were identified as HIV‐1 capsid inhibitors. IC‐2i showed significant anti‐HIV‐1 activity at picomolar concentrations. ABSTRACT The HIV‐1 capsid (CA) is a validated antiviral target that plays critical roles in both the early and late stages of the viral life cycle.
Xujie Zhang, Lin Sun, Laura Walsham, Yuexi Ma, Dang Ding, Mei Wang, Fabao Zhao, Jian Zhang, Zhao Wang, Shujing Xu, Xiangyi Jiang, Yang Zhou, Erik De Clercq, Christophe Pannecouque, Chin‐Ho Chen, David C. Goldstone, Xinyong Liu, Alexej Dick, Peng Zhan   +18 more
wiley   +1 more source

Exonuclease-fused CRISPR-cas system enhances targeted genome editing for functional genomics in soybean. [PDF]

BMC Plant Biol
Devkar V, Ghose K, D'Agostino L, Patil GB.   +3 more
europepmc   +1 more source

Biophysical characterization of Cyclophilin B reveals membrane localization as its primary functional determinant as a prolyl isomerase

Protein Science, Volume 35, Issue 5, May 2026.
Abstract The endoplasmic reticulum (ER) provides a specialized environment for the folding of secreted and membrane proteins, a process supported by many different chaperones. Among these chaperones, peptidyl‐prolyl cis/trans isomerases (PPIases) catalyze a rate‐limiting conformational step in protein folding, yet the principles governing isoform ...
Sarah C. DeVoe, Thomas C. Yost, Ashley J. Newton, Gavin A. Grever, Melissa Fernandez Ayala, Wendell P. Griffith, Robert D. Latvala, Philipp A. M. Schmidpeter   +7 more
wiley   +1 more source

High-Throughput Aptamer Characterization via Real-Time Nuclease Digestion. [PDF]

J Am Chem Soc
Byrd C, Alkhamis O, Castro G, Nguyen TP, Canoura J, Xiao Y.   +5 more
europepmc   +1 more source

Integrating Sr isotopes, microchemistry, and genetics to reconstruct Salmonidae species and life history

Archaeometry, Volume 68, Issue S2, Page S104-S129, May 2026.
Abstract Recent approaches to fisheries research emphasize the importance of the coproduction of knowledge in building resilient and culturally mindful fisheries management frameworks. Despite widespread recognition of the need for Indigenous knowledge and historical reference points as baseline data, archaeological data are rarely included in ...
Ross Salerno, Remi Murdoch, Joanna Elmore, Taylor Wilcox, Jens Hegg, Catherine S. Austin, Michael LeMoine, Jade Luckhurst, Alexandra K. Fraik, Molly Carney   +9 more
wiley   +1 more source

18S and 25S Exonuclease Resistant Ribosomal RNA Molecules Are Produced by 5'-End Modification During TOR Inhibition. [PDF]

Yeast
Rocha MA, Bhavani G, Fleischmann J.
europepmc   +1 more source

Deletions in the S1 domain of Rrp5p cause processing at a novel site in ITS1 of yeast pre-rRNA that depends on Rex4p [PDF]

, 2002
Eppens, N.A., Faber, A.W., Hemert, S. van, Jahangir, R.S., Raue, H.A., rondaij, m, Venema, J., Vos, J.C.   +7 more
core   +2 more sources

Circ‐0030167/IGF2BP1 Induces Mitophagy‐Mediated Ferroptosis via HMOX1 mRNA Stabilization in Pancreatic Cancer

Cancer Science, Volume 117, Issue 5, Page 1362-1379, May 2026.
Our findings identify circ‐0030167/IGF2BP1/HMOX1 axis as a critical regulatory factor targeting mitochondria‐mediated ferroptosis, thereby presenting a novel therapeutic target for PC combination therapies. ABSTRACT Pancreatic cancer (PC) represents a highly aggressive malignancy characterized by a 5 year survival rate of less than 12%.
Qun Zhao, Xihao Yao, Jingjing Lu, Qiyang Chen, Zhiwei Wang, Xiaohong Li, Yuhua Lu   +6 more
wiley   +1 more source

Single-locus enrichment without amplification for sequencing and direct detection of epigenetic modifications. [PDF]

, 2016
Adams, E, Eid, JS, Hagerman, PJ, Hanes, JW, Lam, R, Loomis, EW, Pham, TT, Turner, SW, Wang, JY, Yin, J   +9 more
core   +1 more source