Results 141 to 150 of about 18,119 (268)
Technologies for engineering repetitive DNA
Quantitative Biology, Volume 14, Issue 3, September 2026.Abstract Repetitive DNA, a fundamental architectural element of genomes, is widespread across organisms and comprises about 54% of the human genome. With advances in long‐read sequencing and bioinformatics approaches, highly repetitive sequences can now be characterized in depth.
Shuting Ma, Yali Cui, Yi Wu
wiley +1 more source
Communications ChemistryEnd capping of oligonucleotides by modified nucleotides is essential for boosting resistance to 3’ exonuclease degradation, thereby enhancing their stability and therapeutic efficacy in vivo.
Junlin Wen +9 more
doaj +1 more source
Animal Genetics, Volume 57, Issue 3, June 2026.ABSTRACT Canine congenital cleft palate is one of the most common craniofacial anomalies in dogs, characterized by a failure of the palatal shelves to fuse properly during fetal development, leading to abnormal communication between the oral and nasopharyngeal cavities.
Jonas Donner +5 more
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Medical and Veterinary Entomology, Volume 40, Issue 2, Page 422-440, June 2026.The highlands of eastern Democratic Republic of the Congo (DRC) are home to critically endangered eastern gorillas (Gorilla beringei). Climate change could increase the abundance and distribution of Culicoides‐borne diseases. We utilized morphological and molecular techniques to identify Culicoides spp.
Alisa Kubala +11 more
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Plant, Cell &Environment, Volume 49, Issue 6, Page 3436-3454, June 2026.ABSTRACT Multigenerational stress exposure induces stress memory in plants, influencing resource allocation, defence mechanisms, and productivity. Weed competition imposes both resource‐based (abiotic) and allelopathic (biotic) stress, engaging overlapping hormonal pathways.
Albert O. Kwarteng +4 more
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Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization
Advanced Science, Volume 13, Issue 26, 8 May 2026.This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin +11 more
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Advanced Science, Volume 13, Issue 25, 4 May 2026.Zhang et al. identify M7core, a critical cGAS‐STING pathway‐driven gene signature that is activated in most lupus patients’ blood and links to lupus disease severity, lymphopenia, and lupus nephritis. They further reveal the diagnostic and pathogenic characteristics of M7core and emphasize the importance of assessing pathway activity before initiating ...
Lele Zhang +13 more
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Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.Abstract INTRODUCTION Circular RNAs (circRNAs) are emerging as key regulators of gene expression, synaptic plasticity, and neuronal function in Alzheimer's disease (AD). Here, we characterize the biological actions of circPDE4B, a highly expressed circRNA markedly reduced in AD. METHODS circPDE4B knockdown in neuronal progenitor cells was combined with
Sambhavi Puri +15 more
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Cancer Medicine, Volume 15, Issue 5, May 2026.Molecular profiles and outcomes of CR rate in 74 cases. ABSTRACT Objective To investigate the impact of various molecular characteristics on the outcomes of fertility‐preserving therapy in patients with endometrial cancer (EC) and atypical endometrial hyperplasia (AEH).
Xue‐Qian Qian +4 more
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