Results 151 to 160 of about 18,119 (268)

A Novel Nomogram Incorporating the Aggregate Index of Systemic Inflammation, Clinicopathological Parameters and Molecular Classification to Predict Recurrence of Endometrial Cancer: A Multi‐Center Retrospective Study

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT This study evaluated the aggregate index of systemic inflammation (AISI) for predicting postoperative recurrence in endometrial cancer (EC). A total of 1557 patients were enrolled and divided into training (n = 1030) and validation (n = 527) cohorts. The optimal AISI cutoff was determined by ROC curve analysis.
Chenfan Tian, Na Zeng, Yuan Tu, Chunxia Gong, Jiaxin Yu, Kunying Rao, Peng Jiang   +6 more
wiley   +1 more source

DNA Exonuclease [PDF]

, 2020
openaire   +1 more source

A Genetic Reporter for Visualizing Nitroreductase Activity Using Magnetic Resonance Imaging

Chemistry–Methods, Volume 6, Issue 5, May 2026.
We introduce a reporter gene technology to noninvasively visualize bacterial nitroreductase activity. Our method utilizes a magnetic resonance imaging (MRI) reporter based on aquaporin, which is fused to a destabilizing domain, resulting in their degradation (off‐state).
Jinyang Wan, Asish N. Chacko, Emrys Xu, Kiran Kuriakose, Arnab Mukherjee   +4 more
wiley   +1 more source

Understanding single stranded DNA gaps: from formation to fate. [PDF]

Biochem J
Garg S, Moldovan GL.
europepmc   +1 more source

Computational Design of an mRNA Vaccine Targeting LRP6 for Triple‐Negative Breast Cancer Therapy

Cancer Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background Triple‐negative breast cancer (TNBC) presents a poorer prognosis than other breast cancer subtypes, attributed to its aggressive nature and the lack of specific therapeutic interventions. TNBC has high recurrence rates and limited survival despite current therapies, emphasizing the critical need for improved treatment options.
Pooriya Teimoori, Mohammadreza Heidari
wiley   +1 more source

Increasing Cas12a- and Cas9-mediated deletion sizes with exonucleases. [PDF]

Plant Physiol
Wang X, Clem J, Malzahn A, Qi Y.
europepmc   +1 more source

Integrative Metabolomic and Transcriptomic Profiling Reveals the Chemical and Molecular Basis for Aroma Divergence in Isatis Fruits

Food Frontiers, Volume 7, Issue 3, May 2026.
Integrative metabolomic and transcriptomic analyses revealed the chemical and molecular basis of aroma divergence in fruits of three Isatis species. Distinct volatile profiles and 44 key aroma‐active compounds defined species‐specific sensory characteristics, while co‐expression analysis identified NAC transcription factors and lipid‐derived pathway ...
Rong Chen, Yan Qing, Xiaoshan Geng, Qiaoyun Cai, Lili Wang, Fanglin Liu, Huijun Cheng, Yude Peng, Chunfeng Tang, Huaxi Huang, Qin Liu   +10 more
wiley   +1 more source

The 10–23 DNAzyme in Biosensing and Diagnostics: Applications, Challenges, and Future Directions

Angewandte Chemie, Volume 138, Issue 18, 27 April 2026.
This review focuses on the 10–23 DNAzyme in diagnostics, spanning unregulated and regulated target‐recognition modes, and their functionalization across colorimetric, fluorescent, electrochemical, electrochemiluminescent, and intracellular biosensing strategies.
Connor Nurmi, Jake Brill, Sanne Roumans, Amal Mathai, John D. Brennan, Yingfu Li   +5 more
wiley   +2 more sources

PE-STAR: prime editing with SOS-triggered and RecJ-augmented repair enables high-efficiency editing in Escherichia coli. [PDF]

Nucleic Acids Res
Duan X, Zhang H, Lv J, Fan X, Liu X, Wang Q, Zhang F, Zhang Q, Liu L, Liang L, Liu R.   +10 more
europepmc   +1 more source

RNA Modifications: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 5, May 2026.
Types of RNA modification. We have summarized the currently common types of RNA modifications, including ac4C, m6A, m1A, m5C, m3C, m7G, and ψ, and visually characterized their features through structural formulas. The characteristic structures are marked with a background color different from the background color.
Shiyu Xiao, Tingwen Xiang, Chuan Yang, Xiaohua Wang, Gang Huang, Fei Luo, Zhao Xie, Yueqi Chen   +7 more
wiley   +1 more source