Results 121 to 130 of about 12,706 (198)

The importance of gene polymorphism in familial inheritance of endometriosis

International Journal of Gynecology &Obstetrics, Volume 175, Issue 1, Page 93-105, October 2026.
Abstract Objective The study aimed to investigate familial transmission patterns in women with endometriosis by generating a customized single‐nucleotide polymorphism (SNP) array. Methods Patients aged 18–45 who were diagnosed histopathologically with endometriosis were included in the study.
Hale Goksever Celik, Candan Eker, Berivan Guzelbag, Ercan Bastu, Tuba Gunel   +4 more
wiley   +1 more source

Genomic and Phenotypic Characterization of Two Novel Enterobacter Phages With EDTA‐Enhanced Antibiofilm Activity

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Two novel lytic Enterobacter phages, HHH and RZH, displayed targeted antibiofilm activity against MDR Enterobacter cloacae complex biofilms when combined with EDTA. Activity was strongest within a narrow low‐millimolar EDTA window, reducing biofilm biomass and viable burden, while higher EDTA concentrations shifted the interaction towards antagonism ...
Kashif Haq, Zac Newland‐Smith, Martin Figgit, David Lee, Kwabena Duedu   +4 more
wiley   +1 more source

Ineffectiveness of immune checkpoint inhibitors in prostate cancer: is it just a question of ‘‐mabs’?

The Journal of Pathology, Volume 270, Issue 2, Page 139-162, October 2026.
Abstract Prostate cancer (PCa) is the second most common type of neoplasm, currently treated with a variety of therapeutic agents. Although advances in treatment over the past decade have improved overall survival, patients with advanced PCa eventually progress from hormone‐sensitive PCa to metastatic castration‐resistant PCa.
Giuseppe Schepisi, Irene Torresan, Emilio Francesco Giunta, Sara Bleve, Nicole Brighi, Elisa Tassinari, Sofia Zanuccoli, Maria Concetta Cursano, Cristian Lolli   +8 more
wiley   +1 more source

Identification of Molecular Pathways Underlying Mn(II) Oxidation in Pseudomonas resinovorans

Environmental Microbiology, Volume 28, Issue 10, October 2026.
Transposon mutagenesis in biofilter‐associated Pseudomonas resinovorans MOB‐513 identifies a c‐di‐GMP‐dependent regulatory network involving type IV pili, two‐component systems, and diguanylate cyclases that controls Mn(II) oxidation and biofilm formation, providing new insight into microbial manganese cycling and biofilter performance.
Ainelén Piazza, Lucia Parra, Marilina Gaffuri, Jacob G. Malone, Jorgelina Ottado, Natalia Gottig   +5 more
wiley   +1 more source

Genomic and Phenotypic Classification of Staphylococcus Species Isolated From Delhi Air

Environmental Microbiology Reports, Volume 18, Issue 5, October 2026.
Multiple Staphylococcus spp. were isolated from the outdoor polluted air of the Indian Capital, New Delhi. The bacterial samples were collected from 6 different locations, and the whole genome of four Staphylococcus isolates was sequenced in their entirety. This study presents the comparative genomic analysis of these four isolates.
Himanshu Sen, Joyasree Das, Suman Paul, Manpreet Kaur, Amareshwar Vodapalli, Surajit Bhattacharjee, Manoj Raje, Srinivasan Krishnamurthi, Saumya Raychaudhuri   +8 more
wiley   +1 more source

RNA‐Guided Engineering of the Chloroplast Genome Enabled by Plastid‐Expressed Guide RNAs

Plant Biotechnology Journal, Volume 24, Issue 10, Page 5498-5509, October 2026.
ABSTRACT Our goal is to develop RNA‐guided engineering of the chloroplast genome using the CRISPR/Cas9 system. We designed chloroplast minigenes to obtain properly sized single guide RNAs (sgRNAs) in tobacco chloroplasts. The sgRNA 5′ end is defined by transcription from an rRNA operon promoter, and its 3′ end by processing a downstream tRNA (trnG) or ...
Malihe Mirzaee, Corinne Best, Evelyn V. Wachowski, Pal Maliga   +3 more
wiley   +1 more source

A 4′‐Thioribouridine Modification Mimics 2′‐O‐Methoxyethyl in ASO‐Like 20‐Mers Targeting PTEN Knockdown

ChemBioChem, Volume 27, Issue 18, 28 September 2026.
A 4′‐thiouridine phosphoramidite was prepared and site‐selectively incorporated into PTEN‐targeting gapmer ASOs. Flank‐modified gapmers with defined phosphorothioate linkage patterns maintained potent target knockdown under transfection and gymnotic delivery, matching 2′‐O‐methoxyethyl comparators and highlighting 4′‐thioribose as a valuable motif for ...
Joanna E. Parkes, Caecilie M. M. Benckendorff, Anna L. Malinowska, Jacob Roberts, Harley L. Huynh, Sritama Bose, Loïc M. Cochard, Aisling Ní Cheallaigh, Sarah L. Lovelock, Peter L. Oliver, Gavin J. Miller   +10 more
wiley   +1 more source

Enhanced exonuclease-Cas9 systems promote multiple nucleotide deletions with higher efficiency and broader targeting scope in plants. [PDF]

J Integr Plant Biol
Zhang R, Tang X, He Y, Wang W, Ren Q, Qi Y, Zhang Y.   +6 more
europepmc   +1 more source

Circular Photocaged mRNA for Light‐induced Late‐stage Activation of Translation

Angewandte Chemie International Edition, Volume 65, Issue 39, 21 September 2026.
A clickable photo‐caged 5′ cap (CyCliCap) allows to make Cyclic Click Cap‐containing mRNA (CyCliCap‐mRNA) which is remarkably stable and translationally muted until irradiated, allowing for late‐stage activation of translation in cells by light. ABSTRACT mRNA is a new medical modality as vaccine and raises hopes to become a protein replacement agent ...
Bayram Terzi, Greta Charlotte Dahm, Kristoffer Heintz, Martin Sumser, Yasuaki Kimura, Hiroshi Abe, Andrea Rentmeister   +6 more
wiley   +1 more source

Increasing Cas12a- and Cas9-mediated deletion sizes with exonucleases. [PDF]

Plant Physiol
Wang X, Clem J, Malzahn A, Qi Y.
europepmc   +1 more source