Results 101 to 110 of about 18,714 (239)
Control of expression of the RNases J1 and J2 in bacillus subtilis [PDF]
, 2014 In Bacillus subtilis, the dual activity 5' exo- and endoribonucleases J1 and J2 are important players in mRNA and stable RNA maturation and degradation. Recent work has improved our understanding of their structure and mechanism of action and identified ...
Hébert, A. +3 more
core +1 more source
ChemistryEurope, Volume 3, Issue 6, November 11, 2025.Photocaged dinucleoside tetraphosphates can be incorporated into mRNA by T7 RNA polymerase. Subsequent irradiation with light activates 5′ cap interactions and translation. These 5′ cap analogs are useful tools to probe the functions of naturally occurring dinucleoside tetraphosphates and their role in bacteria and mammalian cells.
Cedrik Kühling +5 more
wiley +1 more source
Exoribonuclease in nonstructural protein 14 (nsp14-ExoN) [PDF]
Science-Business eXchange, 2013 In vitro studies suggest nsp14-ExoN inhibitors could help sensitize coronaviruses to RNA mutagen therapeutics including ribavirin.
openaire +1 more source
Cytoplasmic 5'-3' exonuclease Xrn1p is also a genome-wide transcription factor in yeast [PDF]
, 2014 The 5' to 3' exoribonuclease Xrn1 is a large protein involved in cytoplasmatic mRNA degradation as a critical component of the major decaysome. Its deletion in the yeast Saccharomyces cerevisiae is not lethal, but it has multiple physiological effects ...
Choder, M. +5 more
core +3 more sources
The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity
FEBS Open Bio, Volume 15, Issue 11, Page 1874-1885, November 2025.We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda +9 more
wiley +1 more source
Yeast RNase III triggers polyadenylation-independent transcription termination [PDF]
, 2009 Transcription termination of messenger RNA (mRNA) is normally achieved by polyadenylation followed by Rat1p-dependent 5'-3' exoribonuleolytic degradation of the downstream transcript.
Abou Elela, Sherif +5 more
core +1 more source
WIREs RNA, Volume 16, Issue 6, November/December 2025.RNA‐protein (RNP) complexes formed by a network of RNA–RNA, RNA–protein, and protein–protein interactions are central to gene expression. mRNP compositional heterogeneity underlies precise regulation (e.g., export, storage, translation, and decay), enabling cells to adapt to changing conditions, with changes in composition further linked to stress ...
Theresa Wechsler +2 more
wiley +1 more source
A noncoding RNA produced by arthropod-borne flaviviruses inhibits the cellular exoribonuclease XRN1 and alters host mRNA stability [PDF]
, 2012 All arthropod-borne flaviviruses generate a short noncoding RNA (sfRNA) from the viral 3′ untranslated region during infection due to stalling of the cellular 5′-to-3′ exonuclease XRN1.
Akira, Shizuo +6 more
core +1 more source
Advanced Biology, Volume 9, Issue 9, September 2025.The invasive pest Halyomorpha halys causes significant crop losses requiring innovative pest control strategies such as RNA interference (RNAi). However, oral RNAi is largely ineffective in H. halys. This study shows that double‐stranded DNA (dsDNA) stabilizes dsRNA in saliva by inhibiting a highly expressed nuclease.
Venkata Partha Sarathi Amineni +2 more
wiley +1 more source
Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability [PDF]
, 2018 R loops are nucleic acid structures comprising an DNA-RNA hybrid and a displaced single-stranded DNA. These structures may occur transiently during transcription, playing essential biological functions. However, persistent R loops may become pathological
Aguilera López, Andrés +2 more
core +1 more source