Results 111 to 120 of about 14,025 (272)
Extracellular Vesicles Alter Trophoblast Function in Pregnancies Complicated by COVID‐19
Journal of Extracellular Vesicles, Volume 14, Issue 4, April 2025.ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection and resulting coronavirus disease (COVID‐19) cause placental dysfunction, which increases the risk of adverse pregnancy outcomes. While abnormal placental pathology resulting from COVID‐19 is common, direct infection of the placenta is rare.
Thea N. Golden +12 more
wiley +1 more source
Maturation of 23S ribosomal RNA requires the exoribonuclease RNase T [PDF]
RNA, 1999 Ribosomal RNAs are generally synthesized as long, primary transcripts that must be extensively processed to generate the mature, functional species. In Escherichia coli, it is known that the initial 30S precursor is cleaved during its synthesis by the endonuclease RNase III to generate precursors to the 16S, 23S, and 5S rRNAs.
Zhongwei Li +2 more
openaire +3 more sources
The ApaH-like phosphatase TbALPH1 is the major mRNA decapping enzyme of trypanosomes. [PDF]
PLoS Pathogens, 2017 5'-3' decay is the major mRNA decay pathway in many eukaryotes, including trypanosomes. After deadenylation, mRNAs are decapped by the nudix hydrolase DCP2 of the decapping complex and finally degraded by the 5'-3' exoribonuclease. Uniquely, trypanosomes
Susanne Kramer
doaj +1 more source
Composition and conservation of the mRNA-degrading machinery in bacteria [PDF]
, 2011 RNA synthesis and decay counteract each other and therefore inversely regulate gene expression in pro- and eukaryotic cells by controlling the steady-state level of individual transcripts.
Dharam Singh +2 more
core +4 more sources
Prime Editing: A Revolutionary Technology for Precise Treatment of Genetic Disorders
Cell Proliferation, Volume 58, Issue 4, April 2025.This review outlines the latest research advancements in prime editing technology, delivery strategies, and the challenges that must be addressed to fully realize its therapeutic potential, emphasizing the high potential of prime editing in the remission or cure of genetic diseases. ABSTRACT Genetic diseases have long posed significant challenges, with
Mengyao Li, Yi Lin, Qiang Cheng, Tuo Wei
wiley +1 more source
Inhibition of type I interferon induction and signalling by mosquito-borne flaviviruses [PDF]
, 2017 The Flavivirus genus (Flaviviridae family) contains a number of important human pathogens, including dengue and Zika viruses, which have the potential to cause severe disease.
Clark, Jordan J. +3 more
core +1 more source
Plant Biology, Volume 27, Issue 3, Page 347-361, April 2025.Resistance against Tan spot (caused by Pyrenophora tritici‐repentis) in wheat can involve cell wall defences or an absence of susceptibility factors. Abstract Tan Spot disease is caused by the necrotrophic pathogen Pyrenophora tritici‐repentis (Ptr) and poses a significant threat to global wheat production.
L. C. Ferreira +4 more
wiley +1 more source
Exome resequencing and GWAS for growth, ecophysiology, and chemical and metabolomic composition of wood of Populus trichocarpa. [PDF]
, 2019 BackgroundPopulus trichocarpa is an important forest tree species for the generation of lignocellulosic ethanol. Understanding the genomic basis of biomass production and chemical composition of wood is fundamental in supporting genetic improvement ...
Davis, Mark F +10 more
core
Viruses and the cellular RNA decay machinery. [PDF]
, 2010 The ability to control cellular and viral gene expression, either globally or selectively, is central to a successful viral infection, and it is also crucial for the host to respond and eradicate pathogens.
Gaglia, Marta, Glaunsinger, Britt
core +1 more source
Journal of Biological Chemistry, 2020 mRNA levels are determined by the balance between mRNA synthesis and decay. Protein factors that mediate both processes, including the 5'-3' exonuclease Xrn1, are responsible for a cross-talk between the two processes that buffers steady-state mRNA ...
Jonathan Fischer +6 more
semanticscholar +1 more source