Results 161 to 170 of about 3,495 (190)
Structures of 5′–3′ Exoribonucleases [PDF]
, 2012 5'-3' Exoribonucleases (XRNs) have important functions in RNA processing, RNA turnover and decay, RNA interference, RNA polymerase transcription, and other cellular processes. Their sequences share two highly conserved regions, CR1 and CR2. The cytoplasmic Xrn1 and the nuclear Xrn2/Rat1 are found in yeast and animals, and XRNs are found in most other ...
Jeong Ho, Chang +2 more
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Exoribonucleases and their multiple roles in RNA metabolism
Progress in Molecular Biology and Translational Science, 2000In recent years there has been a dramatic shift in our thinking about ribonucleases (RNases). Although they were once considered to be nonspecific, degradative enzymes, it is now clear that RNases play a central role in every aspect of cellular RNA metabolism, including decay of mRNA, conversion of RNA precursors to their mature forms, and end-turnover
Murray P Deutscher
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Identification of potent inhibitors of arenavirus and SARS-CoV-2 exoribonucleases by fluorescence polarization assay [PDF]
Antiviral Research, 2022 Viral exoribonucleases are uncommon in the world of RNA viruses. To date, they have only been identified in the Arenaviridae and the Coronaviridae families. The exoribonucleases of these viruses play a crucial role in the pathogenicity and interplay with
Fabrice Bailly +2 more
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The presence of only one of five exoribonucleases is sufficient to support the growth of Escherichia coli [PDF]
Journal of Bacteriology, 1992 Escherichia coli contains multiple exoribonucleases. Strains lacking the exoribonucleases RNase II, D, BN, T, and PH are inviable. The introduction of a chromosomal, wild-type copy of the gene for any one of these enzymes is sufficient to allow cell ...
Murray P Deutscher
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The Exosome: A Conserved Eukaryotic RNA Processing Complex Containing Multiple 3′→5′ Exoribonucleases [PDF]
Cell, 1997 We identified a complex in S. cerevisiae, the “exosome,” consisting of the five essential proteins Rrp4p, Rrp41p, Rrp42p, Rrp43p, and Rrp44p (Dis3p).
Philip Mitchell +2 more
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Multiple exoribonucleases are required for the 3' processing of Escherichia coli tRNA precursors in vivo. [PDF]
FASEB Journal, 1993 Our knowledge of the 3′ processing of tRNA precursors is severely limited. Although six exoribonucleases able to act on Escherichia coli tRNA precursors in vitro have been identified, their involvement in tRNA maturation in vivo has not been demonstrated.
Murray P Deutscher
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XRN 5′→3′ exoribonucleases: Structure, mechanisms and functions [PDF]
Biochimica Et Biophysica Acta - Gene Regulatory Mechanisms, 2013 The XRN family of 5' ? 3' exoribonucleases is critical for ensuring the fidelity of cellular RNA turnover in eukaryotes. Highly conserved across species, the family is typically represented by one cytoplasmic enzyme (XRN1/PACMAN or XRN4) and one or more ...
Vinay K Nagarajan +2 more
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Drosophila 5′ → 3′-Exoribonuclease Pacman
Methods in enzymology, 2001Publisher Summary This chapter concentrates on the methods used to express a Drosophila recombinat 5′ → 3′-exoribonuclease, purify the protein, and analyze its activity in vitro . Analysis of early development in Drosophila has shown that RNA localization, control of translation, and mRNA stability are intimately linked.
I V, Chernukhin +2 more
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Escherichiacoli mutants deficient in exoribonucleases
Biochemical and Biophysical Research Communications, 1976Abstract Strain S296, isolated by screening 2000 colonies after nitrosoguanidine mutagenesis, yields extracts with less than 1% of wild-type RNase activity against ( 3 H) poly(U). Unlike other E. coli strains, S296 grows with a doubling time of about 2 hr., both in nutrient broth and in minimal medium, and at 30°, 37° and 42°. The strain retains
N, Nikolaev, V, Folsom, D, Schlessinger
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