RNA Exosome Complex-Mediated Control of Redox Status in Pluripotent Stem Cells [PDF]
Stem Cell Reports, 2017 The RNA exosome complex targets AU-rich element (ARE)-containing mRNAs in eukaryotic cells. We identified a transcription factor, ZSCAN10, which binds to the promoters of multiple RNA exosome complex subunits in pluripotent stem cells to maintain subunit
Maria Skamagki +10 more
europepmc +4 more sources
Transcriptome-wide analysis of alternative routes for RNA substrates into the exosome complex [PDF]
PLoS Genet, 2017 The RNA exosome complex functions in both the accurate processing and rapid degradation of many classes of RNA. Functional and structural analyses indicate that RNA can either be threaded through the central channel of the exosome or more directly access
Clémentine Delan‐Forino +2 more
europepmc +4 more sources
Genome-Wide Characterization of the RNA Exosome Complex in Relation to Growth, Development, and Pathogenicity of Fusarium graminearum. [PDF]
Microbiol Spectr, 2023 The RNA exosome complex is a conserved, multisubunit RNase complex that contributes to the processing and degradation of RNAs in mammalian cells. However, the roles of the RNA exosome in phytopathogenic fungi and how it relates to fungal development and ...
Yuan Y +6 more
europepmc +2 more sources
The CCR4-NOT Complex Physically and Functionally Interacts with TRAMP and the Nuclear Exosome [PDF]
PLoS ONE, 2009 BACKGROUND:Ccr4-Not is a highly conserved multi-protein complex consisting in yeast of 9 subunits, including Not5 and the major yeast deadenylase Ccr4.
Nowel Azzouz +3 more
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Exosome complex orchestrates developmental signaling to balance proliferation and differentiation during erythropoiesis. [PDF]
Elife, 2016 Since the highly conserved exosome complex mediates the degradation and processing of multiple classes of RNAs, it almost certainly controls diverse biological processes.
McIver SC +6 more
europepmc +2 more sources
Distinct and evolutionary conserved structural features of the human nuclear exosome complex. [PDF]
Elife, 2018 The nuclear RNA exosome complex mediates the processing of structured RNAs and the decay of aberrant non-coding RNAs, an important function particularly in human cells. Most mechanistic studies to date have focused on the yeast system.
Gerlach P +6 more
europepmc +2 more sources
The Human Nuclear Exosome Targeting Complex Is Loaded onto Newly Synthesized RNA to Direct Early Ribonucleolysis [PDF]
Cell Reports, 2015 The RNA exosome complex constitutes the major nuclear eukaryotic 3′-5′ exonuclease. Outside of nucleoli, the human nucleoplasmic exosome is directed to some of its substrates by the nuclear exosome targeting (NEXT) complex.
Michał Lubas +5 more
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A budding yeast model for human disease mutations in the EXOSC2 cap subunit of the RNA exosome complex [PDF]
RNA, 2021 Maria C. Sterrett +13 more
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TGF-β Suppression of HBV RNA through AID-Dependent Recruitment of an RNA Exosome Complex
PLoS Pathogens, 2015 Transforming growth factor (TGF)-β inhibits hepatitis B virus (HBV) replication although the intracellular effectors involved are not determined.
Guoxin Liang +10 more
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The Rrp4–exosome complex recruits and channels substrate RNA by a unique mechanism [PDF]
Nat Chem Biol, 2017 Milos A. Cvetkovic +4 more
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