Genome-Wide Characterization of the RNA Exosome Complex in Relation to Growth, Development, and Pathogenicity of Fusarium graminearum [PDF]
Microbiology Spectrum, 2023 The RNA exosome complex is a conserved, multisubunit RNase complex that contributes to the processing and degradation of RNAs in mammalian cells. However, the roles of the RNA exosome in phytopathogenic fungi and how it relates to fungal development and ...
Yanping Yuan +6 more
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RNA-regulatory exosome complex confers cellular survival to promote erythropoiesis. [PDF]
Nucleic Acids Res, 2021 Cellular differentiation requires vast remodeling of transcriptomes, and therefore machinery mediating remodeling controls differentiation. Relative to transcriptional mechanisms governing differentiation, post-transcriptional processes are less well ...
Mehta C +4 more
europepmc +5 more sources
Distinct and evolutionary conserved structural features of the human nuclear exosome complex [PDF]
eLife, 2018 The nuclear RNA exosome complex mediates the processing of structured RNAs and the decay of aberrant non-coding RNAs, an important function particularly in human cells. Most mechanistic studies to date have focused on the yeast system.
Piotr Gerlach +6 more
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The RNA exosome complex degrades expanded hexanucleotide repeat RNA in C9orf72 FTLD/ALS. [PDF]
EMBO J, 2020 Nucleotide repeat expansions in the C9orf72 gene cause frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). Transcribed repeat RNA accumulates within RNA foci and is also translated into toxic dipeptide repeat proteins (DPR).
Kawabe Y +4 more
europepmc +4 more sources
Transcriptome-wide analysis of alternative routes for RNA substrates into the exosome complex. [PDF]
PLoS Genetics, 2017 The RNA exosome complex functions in both the accurate processing and rapid degradation of many classes of RNA. Functional and structural analyses indicate that RNA can either be threaded through the central channel of the exosome or more directly access
Clémentine Delan-Forino +2 more
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Post-transcriptional control of cellular differentiation by the RNA exosome complex. [PDF]
Nucleic Acids Res, 2020 Given the complexity of intracellular RNA ensembles and vast phenotypic remodeling intrinsic to cellular differentiation, it is instructive to consider the role of RNA regulatory machinery in controlling differentiation.
Fraga de Andrade I +2 more
europepmc +5 more sources
Exosome complex orchestrates developmental signaling to balance proliferation and differentiation during erythropoiesis [PDF]
eLife, 2016 Since the highly conserved exosome complex mediates the degradation and processing of multiple classes of RNAs, it almost certainly controls diverse biological processes.
Skye C McIver +6 more
doaj +3 more sources
JAK2V617F+ single-stranded DNA modulates exosome complex activity and DNA-sensing pathways in myeloproliferative neoplasms [PDF]
Molecular Therapy: Nucleic AcidsPhiladelphia chromosome-negative myeloproliferative neoplasms (Ph-MPNs) are characterized by excessive myeloid cell proliferation due to mutations in hematopoietic stem/progenitor cells, most notably JAK2V617F mutation.
Esra Nur Demirtaş +2 more
doaj +3 more sources
Exosome and epithelial–mesenchymal transition: A complex secret of cancer progression [PDF]
Journal of Cellular and Molecular Medicine, 2023 This short communication will enlighten the readers about the exosome and the epithelial‐mesenchymal transition (EMT) related to several complicated events. It also highlighted the therapeutic potential of exosomes against EMT.
Rajib Dhar +5 more
semanticscholar +2 more sources
Development, 2021 Fine-tuned gene expression is crucial for neurodevelopment. The gene expression program is tightly controlled at different levels, including RNA decay.
Ulmke PA +11 more
europepmc +2 more sources