Transcriptome-wide analysis of alternative routes for RNA substrates into the exosome complex. [PDF]
PLoS Genetics, 2017 The RNA exosome complex functions in both the accurate processing and rapid degradation of many classes of RNA. Functional and structural analyses indicate that RNA can either be threaded through the central channel of the exosome or more directly access
Clémentine Delan-Forino +2 more
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The CCR4-NOT complex physically and functionally interacts with TRAMP and the nuclear exosome. [PDF]
PLoS ONE, 2009 BACKGROUND:Ccr4-Not is a highly conserved multi-protein complex consisting in yeast of 9 subunits, including Not5 and the major yeast deadenylase Ccr4.
Nowel Azzouz +3 more
doaj +7 more sources
RNA Exosome Complex-Mediated Control of Redox Status in Pluripotent Stem Cells [PDF]
Stem Cell Reports, 2017 The RNA exosome complex targets AU-rich element (ARE)-containing mRNAs in eukaryotic cells. We identified a transcription factor, ZSCAN10, which binds to the promoters of multiple RNA exosome complex subunits in pluripotent stem cells to maintain subunit
Maria Skamagki +10 more
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Distinct and evolutionary conserved structural features of the human nuclear exosome complex [PDF]
eLife, 2018 The nuclear RNA exosome complex mediates the processing of structured RNAs and the decay of aberrant non-coding RNAs, an important function particularly in human cells. Most mechanistic studies to date have focused on the yeast system.
Piotr Gerlach +6 more
doaj +7 more sources
Genome-Wide Characterization of the RNA Exosome Complex in Relation to Growth, Development, and Pathogenicity of Fusarium graminearum [PDF]
Microbiology Spectrum, 2023 The RNA exosome complex is a conserved, multisubunit RNase complex that contributes to the processing and degradation of RNAs in mammalian cells. However, the roles of the RNA exosome in phytopathogenic fungi and how it relates to fungal development and ...
Yanping Yuan +6 more
doaj +2 more sources
The Pyrococcus Exosome Complex [PDF]
Journal of Biological Chemistry, 2005 The exosome is a conserved eukaryotic enzymatic complex that plays an essential role in many pathways of RNA processing and degradation. Here, we describe the structural characterization of the predicted archaeal exosome in solution using small angle x-ray scattering. The structure model calculated from the small angle x-ray scattering pattern provides
Celso Raul Romero Ramos +3 more
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A complex prediction: three‐dimensional model of the yeast exosome [PDF]
EMBO reports, 2002 We present a model of the yeast exosome based on the bacterial degradosome component polynucleotide phosphorylase (PNPase). Electron microscopy shows the exosome to resemble PNPase but with key differences likely related to the position of RNA binding domains, and to the location of domains unique to the exosome. We use various techniques to reduce the
Patrick Aloy +7 more
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Exosome complex orchestrates developmental signaling to balance proliferation and differentiation during erythropoiesis [PDF]
eLife, 2016 Since the highly conserved exosome complex mediates the degradation and processing of multiple classes of RNAs, it almost certainly controls diverse biological processes.
Skye C McIver +6 more
doaj +2 more sources
The Yeast Ski Complex: Crystal Structure and RNA Channeling to the Exosome Complex [PDF]
Cell, 2013 The Ski complex is a conserved multiprotein assembly required for the cytoplasmic functions of the exosome, including RNA turnover, surveillance, and interference. Ski2, Ski3, and Ski8 assemble in a tetramer with 1:1:2 stoichiometry. The crystal structure of an S. cerevisiae 370 kDa core complex shows that Ski3 forms an array of 33 TPR motifs organized
Felix Halbach +3 more
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Post-transcriptional control of cellular differentiation by the RNA exosome complex. [PDF]
Nucleic Acids Res, 2020 Abstract Given the complexity of intracellular RNA ensembles and vast phenotypic remodeling intrinsic to cellular differentiation, it is instructive to consider the role of RNA regulatory machinery in controlling differentiation.
Fraga de Andrade I +2 more
europepmc +5 more sources