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Chapter 21 Transcriptome Targets of the Exosome Complex in Plants
2008The exosome complex is endowed with the capabilities to conduct 3'-end RNA processing, 3'-end degradation, and surveillance of various RNA substrates. Although the exosome is present in both eukaryotes and archaea, where it plays a central role in cellular RNA metabolism, a substantial degree of variability exists in its modus operandi in the different
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RNA degradation paths in a 12-subunit nuclear exosome complex
Nature, 2015The eukaryotic exosome is a conserved RNA-degrading complex that functions in RNA surveillance, turnover and processing. How the same machinery can either completely degrade or precisely trim RNA substrates has long remained unexplained. Here we report the crystal structures of a yeast nuclear exosome containing the 9-subunit core, the 3'-5' RNases ...
Benjamin Schuch +5 more
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NMR studies of the archaeal exosome complex
2016This study is about structural studies of the exosome from Sulfolobus solfataricus. It includes dynamics analysis (by using Nuclear Magnetic Resonance) of the complex in absence and in presence of RNA. Additional biochemical experiments (degradation assays, fluorescence anisotropy) allowed further description of the interaction exosome-RNA.
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The Role of Aptamer Loaded Exosome Complexes in the Neurodegenerative Diseases
Toxicology and Environmental Health Sciences, 2019Extracellular exosomes formed inside the cytoplasm of cells are small membranous vesicles that provide an important mode of cell-to-cell communication by delivering proteins, lipids and RNA to target cells. Exosomes are found associated with neurodegenerative diseases mainly Parkinson’s disease (PD) and Alzheimer’s diseases (AD), characterized by ...
Yang-Hoon Kim +6 more
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Crystal structure of an RNA-bound 11-subunit eukaryotic exosome complex
Nature, 2013The exosome is the major 3'-5' RNA-degradation complex in eukaryotes. The ubiquitous core of the yeast exosome (Exo-10) is formed by nine catalytically inert subunits (Exo-9) and a single active RNase, Rrp44. In the nucleus, the Exo-10 core recruits another nuclease, Rrp6.
Debora Lika Makino +2 more
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Affinity Proteomic Analysis of the Human Exosome and Its Cofactor Complexes
2019In humans, the RNA exosome consists of an enzymatically inactive nine-subunit core, with ribonucleolytic activity contributed by additional components. Several cofactor complexes also interact with the exosome-these enable the recruitment of, and specify the activity upon, diverse substrates.
Kinga Winczura +3 more
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Radiation therapy‐associated toxicity: Etiology, management, and prevention
Ca-A Cancer Journal for Clinicians, 2021Kyle Wang
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Frailty and cancer: Implications for oncology surgery, medical oncology, and radiation oncology
Ca-A Cancer Journal for Clinicians, 2017Cecilia G Ethun +2 more
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Innovations in research and clinical care using patient‐generated health data
Ca-A Cancer Journal for Clinicians, 2020Heather S L Jim +2 more
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