The significance of exosomes in the development and treatment of hepatocellular carcinoma
Molecular Cancer, 2020 Hepatocellular carcinoma (HCC) is the most commonmalignancy. Exsome plays a significant role in the elucidation of signal transduction pathways between hepatoma cells, angiogenesis and early diagnosis of HCC.
Xin Li +8 more
semanticscholar +1 more source
The role of extracellular vesicles in bone metastasis [PDF]
, 2018 Multiple types of cancer have the specific ability to home to the bone microenvironment and cause metastatic lesions. Despite being the focus of intense investigation, the molecular and cellular mechanisms that regulate the metastasis of disseminated ...
Battafarano, Giulia +3 more
core +2 more sources
Metabolic Profiling of Brain Tissue and Brain‐Derived Extracellular Vesicles in Alzheimer's Disease
Journal of Extracellular VesiclesAlzheimer´s disease (AD) is the most frequent neurodegenerative disorder in the world and is characterised by the loss of memory and other cognitive functions.
Patricia Hernandez +8 more
doaj +1 more source
Ultrasensitive detection of circulating exosomes with a 3D-nanopatterned microfluidic chip
Nature Biomedical Engineering, 2019 The performance of current microfluidic methods for exosome detection is constrained by boundary conditions, as well as fundamental limits to microscale mass transfer and interfacial exosome binding.
Peng Zhang +6 more
semanticscholar +1 more source
Mesenchymal stem cell-based therapy for ischemic stroke [PDF]
, 2016 Ischemic stroke represents a major, worldwide health burden with increasing incidence. Patients affected by ischemic strokes currently have few clinically approved treatment options available.
Anderson, JD +20 more
core +2 more sources
Broad role for YBX1 in defining the small noncoding RNA composition of exosomes. [PDF]
, 2017 RNA is secreted from cells enclosed within extracellular vesicles (EVs). Defining the RNA composition of EVs is challenging due to their coisolation with contaminants, lack of knowledge of the mechanisms of RNA sorting into EVs, and limitations of ...
Lambowitz, Alan M +6 more
core +1 more source
Stem Cell-Derived Exosomes as Nanotherapeutics for Autoimmune and Neurodegenerative Disorders.
ACS Nano, 2019 To dissect therapeutic mechanisms of transplanted stem cells and develop exosome-based nanotherapeutics in treating autoimmune and neurodegenerative diseases, we assessed the effect of exosomes secreted from human mesenchymal stem cells (MSCs) in ...
Milad Riazifar +21 more
semanticscholar +1 more source
The Journal of Cell Biology, 2007 ![][1] Exosomes transport RNA between cells. LOTVALL/MACMILLAN Cells send RNA messages to each other by packing them into tiny membrane vesicles called exosomes, according to Hadi Valadi, Jan Lotvall (Goteborg University, Goteborg, Sweden), and colleagues.
openaire +1 more source
Distinct RNA profiles in subpopulations of extracellular vesicles: apoptotic bodies, microvesicles and exosomes [PDF]
, 2013 Introduction: In recent years, there has been an exponential increase in the number of studies aiming to understand the biology of exosomes, as well as other extracellular vesicles.
Berent-Maoz B +28 more
core +2 more sources
Generation and testing of clinical-grade exosomes for pancreatic cancer.
JCI Insight, 2018 Exosomes are extracellular vesicles produced by all cells with a remarkable ability to efficiently transfer genetic material, including exogenously loaded siRNA, to cancer cells.
Mayela Mendt +16 more
semanticscholar +1 more source