Results 161 to 170 of about 202,955 (306)

RNA surveillance and the exosome [PDF]

open access: yesRNA, 2015
The discoveries that have had the greatest effect on my work over the past 20 years relate to the nuclear RNA surveillance systems, particularly the exosome complex and its cofactors in budding yeast. These insights were made possible, in large part, by technical progress; in the fields of proteomics, genetics, structural biology, high-throughput ...
openaire   +3 more sources

Label-free detection of exosomes from different cellular sources based on surface-enhanced Raman spectroscopy combined with machine learning models [PDF]

open access: yesarXiv
Exosomes are significant facilitators of inter-cellular communication that can unveil cell-cell interactions, signaling pathways, regulatory mechanisms and disease diagnostics. Nonetheless, current analysis required large amount of data for exosome identification that it hampers efficient and timely mechanism study and diagnostics.
arxiv  

Engineering exosomes as refined biological nanoplatforms for drug delivery

open access: yesActa Pharmacologica Sinica, 2017
Exosomes, a subgroup of extracellular vesicles (EVs), have been recognized as important mediators of long distance intercellular communication and are involved in a diverse range of biological processes.
Xin Luan   +5 more
semanticscholar   +1 more source

Microvesicles as vehicles for tissue regeneration: Changing of the guards [PDF]

open access: yes, 2016
Purpose of Review: Microvesicles (MVs) have been recognised as mediators of stem cell function, enabling and guiding their regenerative effects. Recent Findings: MVs constitute one unique size class of extracellular vesicles (EVs) directly shed from ...
Davies, R. Wayne   +3 more
core   +1 more source

Exosomal Epigenetics

open access: yesEMBnet.journal
Epigenetics is the study of heritable changes in gene expression that occur without changes to the underlying DNA sequence. Epigenetic modifications can include DNA methylation, histone modifications, and non-coding RNAs, among others. These modifications can influence the expression of genes by altering the way DNA is packaged and accessed by ...
Papakonstantinou, Eleni   +3 more
openaire   +2 more sources

Exosomes in Cardiovascular Medicine [PDF]

open access: yesCardiology and Therapy, 2017
Exosomes are small, extracellular membrane-bound particles that mediate intercellular transport of a cytosolic cargo. Exosomal transfer of micro-RNA can modify gene expression in targeted cells. Exosome-based endocrine/paracrine signaling has been shown to be involved in a wide range of physiological processes including those associated with ...
openaire   +4 more sources

Exosome membrane bound TNF-receptor for the treatment of rheumatoid arthritis [PDF]

open access: yes, 2017
Rheumatoid arthritis (RA) is an autoimmune disease that causes painful inflammation of the synovium of the patient’s joints. However, current treatments for RA have a variety of drawbacks.
Curley, Kevin, Duong, Natalie
core   +1 more source

Exosomes in Tumour Immunity

open access: yesCurrent Oncology, 2009
Exosomes are nanometre-size vesicles manufactured within late multi-vesicular endosomes and actively secreted into the extracellular environment [...]
Clayton, A., Mason, M.D.
openaire   +3 more sources

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