Results 161 to 170 of about 222,944 (406)

Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation

Nature Biomedical Engineering, 2019
Exosomes are attractive as nucleic-acid carriers because of their favourable pharmacokinetic and immunological properties and their ability to penetrate physiological barriers that are impermeable to synthetic drug-delivery vehicles.
Zhaogang Yang, Zhaogang Yang, Junfeng Shi, Jing Xie, Yifan Wang, Jingyao Sun, Tongzheng Liu, Yarong Zhao, Xiuting Zhao, Xinmei Wang, Yifan Ma, V. Malkoc, Chi-Ling Chiang, W. Deng, Yuanxin Chen, Yuan Fu, K. Kwak, Yamin Fan, Chen Kang, C. Yin, J. Rhee, P. Bertani, Jose Otero, W. Lu, Kyuson Yun, Andrew S. Lee, Wen Jiang, Lesheng Teng, Betty Y. S. Kim, Betty Y. S. Kim, L. J. Lee   +30 more
semanticscholar   +1 more source

Bioengineering Strategies for Treating Neointimal Hyperplasia in Peripheral Vasculature: Innovations and Challenges

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
This review highlights emerging bioengineering strategies for treating neointimal hyperplasia in the peripheral vasculature, focusing on approaches that promote re‐endothelialization, modulate smooth muscle cell phenotype, reduce inflammation, mitigate oxidative stress, and optimize biomechanical compliance.
Nikita Wilson John, Caitlyn Dang, Nidhi Reddy, Calvin Chao, Karen J. Ho, Bin Jiang   +5 more
wiley   +1 more source

Ultrasensitive detection of circulating exosomes with a 3D-nanopatterned microfluidic chip

Nature Biomedical Engineering, 2019
The performance of current microfluidic methods for exosome detection is constrained by boundary conditions, as well as fundamental limits to microscale mass transfer and interfacial exosome binding.
Peng Zhang, Xin Zhou, M. He, Yuqin Shang, Ashley L. Tetlow, A. Godwin, Yong Zeng   +6 more
semanticscholar   +1 more source

Controlled Release of Human Dental Pulp Stem Cell‐Derived Exosomes from Hydrogels Attenuates Temporomandibular Joint Osteoarthritis

Advanced Healthcare Materials, EarlyView.
Exosomes can reduce tissue damage in temporomandibular joint osteoarthritis (TMJOA), but rapid clearance limits their efficacy. This study encapsulates exosomes in hyaluronic acid hydrogels for controlled release. In a rat model, hydrogel‐encapsulated exosomes outperform free exosomes in preserving bone integrity and reducing tissue destruction ...
Victor Diez‐Guardia, Yajing Tian, Yunzhe Guo, Jiaying Li, Shengjie Cui, Cécile A. Dreiss, Eileen Gentleman, Xuedong Wang   +7 more
wiley   +1 more source

The exosome exchange [PDF]

The Journal of Cell Biology, 2007
![][1] Exosomes transport RNA between cells. LOTVALL/MACMILLAN Cells send RNA messages to each other by packing them into tiny membrane vesicles called exosomes, according to Hadi Valadi, Jan Lotvall (Goteborg University, Goteborg, Sweden), and colleagues.
openaire   +1 more source

Cell-to-Cell Communication in Learning and Memory: From Neuro- and Glio-Transmission to Information Exchange Mediated by Extracellular Vesicles [PDF]

, 2019
Most aspects of nervous system development and function rely on the continuous crosstalk between neurons and the variegated universe of non-neuronal cells surrounding them.
Di Liegro, Carlo Maria, Di Liegro, Italia, Schiera, Gabriella   +2 more
core   +1 more source

Encapsulation of Small Extracellular Vesicles into Selectively Disassemblable Shells of PEGylated Metal‐Phenolic Networks

Advanced Healthcare Materials, EarlyView.
Small extracellular vesicles (sEVs) are encapsulated into protective shells composed of metal‐phenolic networks (MPNs) and secondary poly(ethylene glycol) layers. This surface modification approach enhances the storage stability of sEVs while maintaining their integrity and functionality. The shells can be selectively disassembled under mild conditions.
Chenyu Wang, Ailifeire Fulati, Kenta Kimura, Xianglan Li, Joseph J. Richardson, Mitsuru Naito, Kanjiro Miyata, Takanori Ichiki, Hirotaka Ejima   +8 more
wiley   +1 more source

Stem Cell-Derived Exosomes as Nanotherapeutics for Autoimmune and Neurodegenerative Disorders.

ACS Nano, 2019
To dissect therapeutic mechanisms of transplanted stem cells and develop exosome-based nanotherapeutics in treating autoimmune and neurodegenerative diseases, we assessed the effect of exosomes secreted from human mesenchymal stem cells (MSCs) in ...
Milad Riazifar, M. Mohammadi, E. Pone, Ashish S. Yeri, Cecilia Lässer, Aude I. Ségaliny, L. McIntyre, G. Shelke, G. Shelke, E. Hutchins, Ashley Hamamoto, Erika N Calle, Rossella Crescitelli, Wenbin Liao, Victor Pham, Yanan Yin, Jayapriya Jayaraman, Jonathan R. T. Lakey, C. Walsh, K. Keuren-Jensen, J. Lötvall, Weian Zhao   +21 more
semanticscholar   +1 more source

Mesenchymal stem cell-based therapy for ischemic stroke [PDF]

, 2016
Ischemic stroke represents a major, worldwide health burden with increasing incidence. Patients affected by ischemic strokes currently have few clinically approved treatment options available.
Anderson, JD, Bardini, RL, Bauer, G, Bramlett, CS, Chedin, F, Contreras, Z, Dunbar, GL, El-Andaloussi, S, Fiehn, O, Fink, KD, Fury, B, Hendrix, KJ, Hoon, M, Hwang, B, Johansson, HJ, Lehtiö, J, Mulligan, MS, Nolta, JA, Pham, MT, Rossignol, J, Showalter, M   +20 more
core   +2 more sources

Advanced Multipurpose Spectroscopic Nanobio‐Device for Concurrent Lab‐on‐a‐Chip Label‐Free Separation and Detection of Extracellular Vesicles as Key‐Biomarkers for Point‐of‐Care Cardiovascular Disease Diagnostics

Advanced Healthcare Materials, EarlyView.
AIMSPec‐LoC is a novel lab‐on‐a‐chip platform integrating size‐based extracellular vesicle (EVs) separation with label‐free Raman spectroscopy and AI‐powered classification via SKiNET. This high‐throughput, portable system enables real‐time, multiplexed molecular fingerprinting of EVs from biofluids, offering transformative potential for early, non ...
Emma Buchan, Jonathan James Stanley Rickard, Mark Robert Thomas, Pola Goldberg Oppenheimer   +3 more
wiley   +1 more source