Results 171 to 180 of about 222,944 (406)

Characterization of Extracellular Vesicles from Human Saliva: Effects of Age and Isolation Techniques

Cells
Salivary extracellular vesicles (EVs) represent an attractive source of biomarkers due to the accessibility of saliva and its non-invasive sampling methods.
Lucia Reseco, Angela Molina-Crespo, Mercedes Atienza, Esperanza Gonzalez, Juan Manuel Falcon-Perez, Jose L. Cantero   +5 more
doaj   +1 more source

Production of Living Nanoparticles for Blood Cancer Therapy [PDF]

, 2018
Current cancer therapies leave much to be desired because they are very harmful to the patient and cause a significant decrease in quality of life. Chimeric Antigen Receptors (CAR) are a promising novel approach for treating specific types of leukemia ...
Mitchell, Peter, Pierotti, Michael, Piro, Matthew   +2 more
core   +1 more source

Exosomes promote pre-metastatic niche formation in ovarian cancer. [PDF]

, 2019
Ovarian cancer is one of the most common gynecological malignancies. Upon initial diagnosis, the majority of patients present with widespread metastatic growth within the peritoneal cavity. This metastatic growth occurs in stages, with the formation of a
Dean, Dylan C, Duan, Zhenfeng, Feng, Wenlong, Hornicek, Francis J, Shi, Huirong   +4 more
core   +2 more sources

CLDN18.2 CAR‐derived Extracellular Vesicle Immunotherapy Improves Outcome in Murine Pancreatic Cancer

Advanced Healthcare Materials, EarlyView.
CLDN18.2 CAR‐T cell‐derived small extracellular vesicles (CAR‐sEVs) display potent cytotoxicity and prolong survival in preclinical pancreatic cancer models. They contain functional CAR proteins and granzyme B, exhibit antigen specificity, and effectively target tumor cells while sparing healthy cells.
Yue Qing, Ke Jiang, Hua Jiang, Yaru Zhao, Chu‐Hu Lai, Alexandra Aicher, Zonghai Li, Christopher Heeschen   +7 more
wiley   +1 more source

Distinct RNA profiles in subpopulations of extracellular vesicles: apoptotic bodies, microvesicles and exosomes [PDF]

, 2013
Introduction: In recent years, there has been an exponential increase in the number of studies aiming to understand the biology of exosomes, as well as other extracellular vesicles.
Berent-Maoz B, Chaput N, Choi DS, Cocucci E, Droin N, Ekström K, Escola JM, Freyssinet JM, György B, Johnstone RM, Kalra H, Keller S, Lehmann BD, Lespagnol A, Lässer C, Lässer C, Mathivanan S, Rajendran L, Ratajczak J, Simpson RJ, Stoorvogel W, Suliman A, Théry C, Turiák L, Valadi H, van der Pol E, van der Pol E, van Niel G, Yu X   +28 more
core   +2 more sources

Tumor‐Targeted Exosome‐Based Heavy Atom‐Free Nanosensitizers With Long‐Lived Excited States for Safe and Effective Sono‐Photodynamic Therapy of Solid Tumors

Advanced Healthcare Materials, EarlyView.
Engineered exosome‐based heavy atom‐free nanosensitizers are developed for safe and targeted sono‐photodynamic therapy of solid tumors. The IR820‐TPE‐loaded, biotin‐conjugated exosomes (IR820‐TPE@B‐Exo) demonstrate significant promise for NIR fluorescence imaging‐guided sono‐photodynamic cancer therapy.
Van‐Nghia Nguyen, Thuy Giang Nguyen Cao, Hyunsun Jeong, Quan Truong Hoang, Binh T. T. Pham, Jieun Bang, Chang Woo Koh, Ji Hee Kang, Jeong Hyun Lee, Xiaofeng Wu, Won Jong Rhee, Young Tag Ko, K. M. K. Swamy, Sungnam Park, JaeHong Park, Min Suk Shim, Juyoung Yoon   +16 more
wiley   +1 more source

The role of exosomes and exosomal microRNA in diabetic cardiomyopathy

Frontiers in Endocrinology
Diabetic cardiomyopathy, a formidable cardiovascular complication linked to diabetes, is witnessing a relentless surge in its incidence. Despite extensive research efforts, the primary pathogenic mechanisms underlying this condition remain elusive. Consequently, a critical research imperative lies in identifying a sensitive and dependable marker for ...
Shiyu Gao, Yue Dong, Chentao Yan, Tianhao Yu, Hongbo Cao   +4 more
openaire   +3 more sources

Generation and testing of clinical-grade exosomes for pancreatic cancer.

JCI Insight, 2018
Exosomes are extracellular vesicles produced by all cells with a remarkable ability to efficiently transfer genetic material, including exogenously loaded siRNA, to cancer cells.
Mayela Mendt, S. Kamerkar, H. Sugimoto, Kathleen M. McAndrews, Chia-Chin Wu, Mihai Gagea, Sujuan Yang, E. R. Blanko, Q. Peng, Xiaoyan Ma, J. Marszalek, A. Maitra, C. Yee, K. Rezvani, E. Shpall, Valerie S. LeBleu, R. Kalluri   +16 more
semanticscholar   +1 more source

Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting

Advanced Materials, EarlyView.
CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu, Won Joon Kim, Hyunjin Lee, Xiaoping Bao, Pilnam Kim   +4 more
wiley   +1 more source

Immunoregulatory Potential of Exosomes Derived from Cancer Stem Cells. [PDF]

, 2020
Head and neck squamous cell carcinomas (HNSCCs) are malignancies that originate in the mucosal lining of the upper aerodigestive tract. Despite advances in therapeutic interventions, survival rates among HNSCC patients have remained static for years ...
Abouyared, Marianne, Anderson, Johnathon D, Archard, Joehleen A, Belafsky, Peter C, Beliveau, Angela, Bewley, Arnaud F, Birkeland, Andrew, Clayton, Shannon M, Farwell, D Gregory, Rao, Shyam, Wagner, Joseph   +10 more
core   +1 more source