Results 201 to 210 of about 177,584 (349)

Aptamer‐Engineered Ellipsometry for Clinical Detection of BALF‐Derived Exosomes: Multi‐Level Engineering for Prognostic Evaluation of Immunotherapy Responses

Advanced Science, EarlyView.
A novel ellipsometry platform functionalized with truncated PD‐L1 aptamers are developed to enable ultrasensitive detection of BALF‐derived exosomes. Through chemical ligand tailoring, mechanical sensing optimization, and tumor‐proximal fluid sampling, the system precisely stratifies ICI responders and non‐responders, offering superior sensitivity and ...
Euna Jeong, Jung Hyun Choi, Minyoung Lee, Jun Hyeok Lim, Seokho Jung, Yeeun Woo, Joo‐young Kim, Jaehyeon Ok, Lucia Kim, Woo‐jin Jeong, Won Chegal, Hyun Mo Cho, Chulhwan Park, Jiyoon Bu, Dong Hyung Kim, Taek Lee   +15 more
wiley   +1 more source

Engineering exosomes for targeted neurodegenerative therapy: innovations in biogenesis, drug loading, and clinical translation. [PDF]

Theranostics
Huang Q, Wang S, Liu Z, Rao L, Cheng K, Mao X.   +5 more
europepmc   +1 more source

Acetylation Regulates ACSL4 Degradation Through Chaperone‐Mediated Autophagy to Alleviate Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Intervertebral disc degeneration is triggered by ACSL4 accumulation‐mediated ferroptosis of nucleus pulposus cells due to CMA dysfunction. KAT2B promotes ACSL4 degradation via CMA through acetylation. AAV‐mediated LAMP2A delivery or engineered exosomes rescue nucleus pulposus cell senescence and disc degeneration.
Zhouwei Wu, Zhichen Jiang, Chenglong Hong, Shu Yang, Shuqing Jin, Chenyu Wu, Kaijie Guo, Jiang Liu, Shaobo Xu, Chenggui Wang, Xiangyang Wang   +10 more
wiley   +1 more source

Exosomes in aging and age-related disorders: mechanisms, therapeutic potentials, and challenges. [PDF]

J Transl Med
Safaei S, Sohrabi S, Zahmatkesh P, Soltani-Zangbar MS, Maleki LA.   +4 more
europepmc   +1 more source

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

Nature Cell Biology, 2015
B. Costa-Silva, Nicole M. Aiello, A. Ocean, Swarnima Singh, Haiying Zhang, B. K. Thakur, A. Becker, Ayuko Hoshino, M. T. Mark, H. Molina, J. Xiang, Tuo Zhang, T. Theilen, G. García‐Santos, Caitlin Williams, Yonathan Ararso, Yujie Huang, G. Rodrigues, Tang-Long Shen, K. Labori, I. Lothe, E. Kure, Jonathan M. Hernandez, A. Doussot, Saya H. Ebbesen, P. Grandgenett, M. Hollingsworth, Maneesh Jain, K. Mallya, S. Batra, W. Jarnagin, R. Schwartz, Irina R Matei, H. Peinado, B. Stanger, J. Bromberg, D. Lyden   +36 more
semanticscholar   +1 more source

AI‐Guided SERS Defines a Pan‐Cancer Diagnostic Biomarker

Advanced Science, EarlyView.
An AI‐enabled SERS platform integrates automated exosome enrichment with molecular fingerprinting to enable accurate early detection and differential diagnosis of ten common cancers. The system identifies exosomal dATP as a universal Raman biomarker, offering a scalable, noninvasive, and clinically translatable approach for precision oncology ...
Cai Zhang, Wen‐Hui Zhao, Duo Zuo, Tianxing Zhou, Wenjing Hou, Lingwei Wang, Shangheng Shi, Yang Yang, Yuanyuan Liu, Shao‐Kai Sun, Li Ren, Zhaoxiang Ye, Dingbin Liu, Dong Li, Xiaoyuan Chen, Jihui Hao   +15 more
wiley   +1 more source

Exosomes Transfer ST6GAL1-mediated Therapeutic Resistance in Rectal Cancer Cells. [PDF]

Cancer Genomics Proteomics
Lever JMP, Irwin RK, Somasundaram V, Song Y, McLeod CM, Smithson M, Williams G, Chong Z, Hardiman KM.   +8 more
europepmc   +1 more source

Identification of lung adenocarcinoma-specific exosome RNAs in peripheral blood by RNA-Seq analysis.

, 2020
Liu Xq, Amanda Tufman, Rosemarie Kiefl, Li Gf, Ma Ql, Huber Rm   +5 more
openalex   +2 more sources

PD‐L1 on Tumor‐Derived Extracellular Vesicles Induces CD8+ T Cell Terminal Exhaustion and Mediates Anti‐PD‐1 Resistance in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
Immunotherapy fails in head and neck squamous cell carcinoma (HNSCC) due to terminally exhausted T (Texterm) cells. Tumor‐derived PD‐L1+ extracellular vesicles promote CD8‐Texterm cells differentiation by upregulating BATF. Stromal Texterm density serves as a potent biomarker for predicting immunotherapy resistance, highlighting a novel EV‐mediated ...
Ruihua Fang, Bixue Huang, Yun Li, Zhimou Cai, Yicheng Deng, Xiaoqing Cen, Wei Sun, Jinhong Zhang, Zhenglin Xu, Wenbin Guo, Yi Lyu, Shiyun Luo, Zhesheng Chen, Kexing Lyu, Weiping Wen, Wenbin Lei   +15 more
wiley   +1 more source

Effects of exosomes from different origins on osteoclasts. [PDF]

J Orthop Surg Res
Yuan M, Zhu T, Wang C, Xia Q, Wang Y.
europepmc   +1 more source