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Pseudomonas aeruginosaExotoxin A
New England Journal of Medicine, 1980Pseudomonas aeruginosa is an opportunistic pathogen that causes more than 100,000 infections in the United States each year. Pseudomonas infections are associated with considerable morbidity and mortality despite the use of modern antibiotics.1 Recognition of the limitations of existing therapy for pseudomonas disease has stimulated renewed interest in
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Kawasaki Disease and Staphylococcal Exotoxins
Archives of Dermatology, 1980To the Editor.— In their recent report of a possible case of Kawasaki disease, Schlossberg et al 1 discuss the possibility that a staphylococcal exotoxin, found in the patient's vaginal discharge, may have been responsible for her symptoms. The pyrogenic exotoxin that they isolated, however, lacked exfoliative activity in the rabbit and mouse.
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Pseudomonas aeruginosa exotoxin A
1997Abstract Pseudomonas aeruginosa exotoxin A (PEA, MW 66 kDa, 613 amino acids, sequence accession number: PSEETA K01397) consists of three major domains (Allured et al. 1986), as indicated in Fig. 1. The N-terminal domain la (amino acids 1-252) binds to the ai-macroglobulin receptor at the cell surface (Kounnas et al.
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Mechanisms of Resistance to Immunotoxins Containing Pseudomonas Exotoxin A in Cancer Therapy
Biomolecules, 2020Michael Dieffenbach, Ira Pastan
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