Pseudomonas Exotoxin A: optimized by evolution for effective killing [PDF]
Frontiers in Microbiology, 2015 Pseudomonas Exotoxin A (PE) is the most toxic virulence factor of the pathogenic bacterium Pseudomonas aeruginosa. This review describes current knowledge about the intoxication pathways of PE.
Philipp Wolf
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Pseudomonas Exotoxin-Based Immunotoxins: Over Three Decades of Efforts on Targeting Cancer Cells With the Toxin [PDF]
Frontiers in Oncology, 2021 Cancer is one of the prominent causes of death worldwide. Despite the existence of various modalities for cancer treatment, many types of cancer remain uncured or develop resistance to therapeutic strategies.
Marc G Aucoin, Ali Jahanian-Najafabadi
exaly +4 more sources
Protection of the Furin Cleavage Site in Low-Toxicity Immunotoxins Based on Pseudomonas Exotoxin A [PDF]
Toxins, 2016 Recombinant immunotoxins (RITs) are fusions of an Fv-based targeting moiety and a toxin. Pseudomonas exotoxin A (PE) has been used to make several immunotoxins that have been evaluated in clinical trials.
Gaurav Bhardwaj +2 more
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Differences in Genetic Background Contribute to Pseudomonas Exotoxin A-Induced Hepatotoxicity in Rats [PDF]
Toxins, 2017 Pseudomonas aeruginosa exotoxin A (PEA) causes severe hepatotoxicity in experimental animals and is useful in investigations of immune-mediated liver injury.
Yi-Hsun Chen +2 more
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HER2-Specific Pseudomonas Exotoxin A PE25 Based Fusions: Influence of Targeting Domain on Target Binding, Toxicity, and In Vivo Biodistribution [PDF]
Pharmaceutics, 2020 The human epidermal growth factor receptor 2 (HER2) is a clinically validated target for cancer therapy, and targeted therapies are often used in regimens for patients with a high HER2 expression level.
Sarah Lindbo, Anna Orlova, Wen Yin
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Pseudomonas Exotoxin Immunotoxins and Anti-Tumor Immunity: From Observations at the Patient’s Bedside to Evaluation in Preclinical Models [PDF]
Toxins, 2019 Immunotoxins are protein drugs composed of a targeting domain genetically fused to a protein toxin. One killing domain being explored is a truncated Pseudomonas exotoxin A (PE).
Ira Pastan
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In Vitro Evaluation of Vegf-Pseudomonas Exotoxin: A Conjugated on Tumor Cells [PDF]
Advanced Biomedical Research, 2017 Background: Angiogenesis which occurs mandatory in solid tumors, is a critical step in malignancy progression. Vascular endothelial growth factor (VEGF) is mainly responsible for angiogenesis process and facilitates the formation of new vessels ...
Jahangir Langari +10 more
doaj +2 more sources
Mechanisms of Resistance to Immunotoxins Containing Pseudomonas Exotoxin A in Cancer Therapy [PDF]
Biomolecules, 2020 Immunotoxins are a class of targeted cancer therapeutics in which a toxin such as Pseudomonas exotoxin A (PE) is linked to an antibody or cytokine to direct the toxin to a target on cancer cells.
Michael Dieffenbach, Ira Pastan
doaj +2 more sources
Immunogenicity of Immunotoxins Containing Pseudomonas Exotoxin A: Causes, Consequences, and Mitigation [PDF]
Frontiers in Immunology, 2020 Immunotoxins are cytolytic fusion proteins developed for cancer therapy, composed of an antibody fragment that binds to a cancer cell and a protein toxin fragment that kills the cell.
Ronit Mazor, Ira Pastan
doaj +2 more sources
Pseudomonas aeruginosa exotoxin A is not essential for corneal disease severity or bacterial survival [PDF]
Infection and ImmunityPseudomonas aeruginosa produces multiple toxins and exoenzymes that contribute to its survival and ability to cause disease. In the current study, we examined whether the type II-secreted cytotoxin Exotoxin A (ToxA) is required for P.
James D. Begando +5 more
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