Results 1 to 10 of about 34,146 (129)

Functions of ADP-ribose transferases in the maintenance of telomere integrity

Cellular and Molecular Life Sciences, 2022
AbstractThe ADP-ribose transferase (ART) family comprises 17 enzymes that catalyze mono- or poly-ADP-ribosylation, a post-translational modification of proteins. Present in all subcellular compartments, ARTs are implicated in a growing number of biological processes including DNA repair, replication, transcription regulation, intra- and extra-cellular ...
Elise Fouquerel, Daniela Muoio, Fouquerel Elise   +2 more
exaly   +4 more sources

Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase.

Journal of Biological Chemistry, 1992
Two classes of enzymes, poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferases, catalyze covalent attachment of multiple or single residues, respectively, of the ADP-ribose moiety of NAD+ to various proteins. In order to find good inhibitors of poly(ADP-ribose) synthetase free of side actions and applicable to in vivo studies, we made a large ...
M, Banasik, H, Komura, M, Shimoyama, K, Ueda   +3 more
semanticscholar   +4 more sources

Biallelic ADPRHL2 mutations in complex neuropathy affect ADP ribosylation and DNA damage response

Life Science Alliance, 2021
This work studies known and new ADPRHL2 mutations with different disease mechanisms overall indicating that loss of nuclear ARH3 alone is pathogenic via dysregulated nuclear ADP ribosylation.
Danique Beijer, Thomas Agnew, Johannes Gregor Matthias Rack, Evgeniia Prokhorova, Tine Deconinck, Berten Ceulemans, Stojan Peric, Vedrana Milic Rasic, Peter De Jonghe, Ivan Ahel, Jonathan Baets   +10 more
doaj   +2 more sources

ADP-Ribosylation and Antiviral Resistance in Plants

Viruses, 2023
ADP-ribosylation (ADPRylation) is a versatile posttranslational modification in eukaryotic cells which is involved in the regulation of a wide range of key biological processes, including DNA repair, cell signalling, programmed cell death, growth and ...
Nadezhda Spechenkova, Natalya O. Kalinina, Sergey K. Zavriev, Andrew J. Love, Michael Taliansky   +4 more
doaj   +2 more sources

The DarT/DarG Toxin–Antitoxin ADP-Ribosylation System as a Novel Target for a Rational Design of Innovative Antimicrobial Strategies

Pathogens, 2023
The chemical modification of cellular macromolecules by the transfer of ADP-ribose unit(s), known as ADP-ribosylation, is an ancient homeostatic and stress response control system.
Giuliana Catara, Rocco Caggiano, Luca Palazzo   +2 more
doaj   +2 more sources

Investigation of the action of poly(ADP-ribose)-synthesising enzymes on NAD+ analogues

Beilstein Journal of Organic Chemistry, 2017
ADP-ribosyl transferases with diphtheria toxin homology (ARTDs) catalyse the covalent addition of ADP-ribose onto different acceptors forming mono- or poly(ADP-ribos)ylated proteins. Out of the 18 members identified, only four are known to synthesise the
Sarah Wallrodt, Edward L. Simpson, Andreas Marx   +2 more
doaj   +2 more sources

Mono(ADP-ribosyl)ation Enzymes and NAD⁺ Metabolism: A Focus on Diseases and Therapeutic Perspectives

Cells, 2021
Mono(ADP-ribose) transferases and mono(ADP-ribosyl)ating sirtuins use NAD+ to perform the mono(ADP-ribosyl)ation, a simple form of post-translational modification of proteins and, in some cases, of nucleic acids.
Palmiro Poltronieri, Angela Celetti, Luca Palazzo   +2 more
doaj   +2 more sources

Crystal Structure of Human ADP-ribose Transferase ARTD15/PARP16 Reveals a Novel Putative Regulatory Domain [PDF]

Journal of Biological Chemistry, 2012
ADP-ribosylation is involved in the regulation of DNA repair, transcription, and other processes. The 18 human ADP-ribose transferases with diphtheria toxin homology include ARTD1/PARP1, a cancer drug target. Knowledge of other family members may guide therapeutics development and help evaluate potential drug side effects.
Tobias, Karlberg, Ann-Gerd, Thorsell, Åsa, Kallas, Herwig, Schüler   +3 more
openaire   +3 more sources

Regulation of poly(ADP-ribose) polymerase 1 activity by the phosphorylation state of the nuclear NAD biosynthetic enzyme NMN adenylyl transferase 1 [PDF]

Proceedings of the National Academy of Sciences, 2007
Nuclear NAD + metabolism constitutes a major component of signaling pathways. It includes NAD + -dependent protein deacetylation by members of the Sir2 family and protein modification by poly(ADP-ribose) polymerase 1 (PARP-1).
Felicitas, Berger, Corinna, Lau, Mathias, Ziegler   +2 more
openaire   +3 more sources

Mono-ADP-ribosylation, a MARylationmultifaced modification of protein, DNA and RNA: characterizations, functions and mechanisms

Cell Death Discovery
The functional alterations of proteins and nucleic acids mainly rely on their modifications. ADP-ribosylation is a NAD+-dependent modification of proteins and, in some cases, of nucleic acids.
Hao Wu, Anqi Lu, Jiuzhi Yuan, Yang Yu, Chongning Lv, Jincai Lu   +5 more
doaj   +2 more sources