Results 11 to 20 of about 34,146 (129)

In silico characterization of the family of PARP-like poly(ADP-ribosyl)transferases (pARTs)

BMC Genomics, 2005
Background ADP-ribosylation is an enzyme-catalyzed posttranslational protein modification in which mono(ADP-ribosyl)transferases (mARTs) and poly(ADP-ribosyl)transferases (pARTs) transfer the ADP-ribose moiety from NAD onto specific amino acid side ...
Dittmar Katharina, Bazan Fernando, Reche Pedro A, Otto Helge, Haag Friedrich, Koch-Nolte Friedrich   +5 more
doaj   +2 more sources

PARylation-mediated post-transcriptional modifications in cancer immunity and immunotherapy

Frontiers in Immunology
Poly-ADP-ribosylation (PARylation) is a post-translational modification in which ADP-ribose is added to substrate proteins. PARylation is mediated by a superfamily of ADP-ribosyl transferases known as PARPs and influences a wide range of cellular ...
Kazuya Matsumoto, Yoshinori Matsumoto, Jun Wada   +2 more
doaj   +2 more sources

PARP7 as a new target for activating anti-tumor immunity in cancer

EMBO Molecular Medicine
ADP-ribosyl transferases (ARTs) are a family of enzymes which catalyze the addition of a chain (PARylation) or a single moiety (MARylation) of ADP-ribose to their substrates.
Katerina Popova, Johannes Benedum, Magdalena Engl, Carola Lütgendorf-Caucig, Piero Fossati, Joachim Widder, Klaus Podar, Dea Slade   +7 more
doaj   +2 more sources

Global isonicotinylome analysis identified SMAD3 isonicotinylation promotes liver cancer cell epithelial–mesenchymal transition and invasion

iScience
Summary: Histone lysine isonicotinylation (Kinic) induced by isoniazid (INH) was recently identified as a post-translational modification in cells. However, global cellular non-histone proteins Kinic remains unclear.
Yixiao Li, Yuhan Jiang, Haoyi Yan, Ziheng Qin, Yidi Peng, Danyu Lv, Hongquan Zhang   +6 more
doaj   +2 more sources

Streptomyces coelicolor macrodomain hydrolase SCO6735 cleaves thymidine-linked ADP-ribosylation of DNA

Computational and Structural Biotechnology Journal, 2022
ADP-ribosylation is an ancient, highly conserved, and reversible covalent modification critical for a variety of endogenous processes in both prokaryotes and eukaryotes.
Andrea Hloušek-Kasun, Petra Mikolčević, Johannes Gregor Matthias Rack, Callum Tromans-Coia, Marion Schuller, Gytis Jankevicius, Marija Matković, Branimir Bertoša, Ivan Ahel, Andreja Mikoč   +9 more
doaj   +1 more source

Why structure and chain length matter: on the biological significance underlying the structural heterogeneity of poly(ADP-ribose)

Nucleic Acids Research, 2021
Poly(ADP-ribosyl)ation (PARylation) is a multifaceted post-translational modification, carried out by poly(ADP-ribosyl)transferases (poly-ARTs, PARPs), which play essential roles in (patho-) physiology, as well as cancer therapy.
Julia M Reber, A. Mangerich
semanticscholar   +1 more source

The expanding field of non-canonical RNA capping: new enzymes and mechanisms

Royal Society Open Science, 2021
Recent years witnessed the discovery of ubiquitous and diverse 5′-end RNA cap-like modifications in prokaryotes as well as in eukaryotes. These non-canonical caps include metabolic cofactors, such as NAD+/NADH, FAD, cell wall precursors UDP-GlcNAc ...
Jana Wiedermannová, Christina Julius, Yulia Yuzenkova   +2 more
doaj   +1 more source

Nicotinamide Riboside Vitamin B3 Mitigated C26 Adenocarcinoma–Induced Cancer Cachexia

Frontiers in Pharmacology, 2021
Nicotinamide riboside (NR), vitamin B3, is a substrate for nicotinamide adenine dinucleotide (NAD+)–consuming enzymes and is a coenzyme for hydride-transfer enzymes, including adenosine diphosphate (ADP)–ribose transferases, poly (ADP-ribose) polymerases,
Jong Min Park, Young Min Han, Ho Jae Lee, Yong Jin Park, Ki Baik Hahm, Ki Baik Hahm   +5 more
doaj   +1 more source

Poly(ADP-ribose) glycohydrolase coordinates meiotic DNA double-strand break induction and repair independent of its catalytic activity

Nature Communications, 2020
Poly(ADP-ribosyl)ation is a reversible post-translational modification synthetized by ADP-ribose transferases and removed by poly(ADP-ribose) glycohydrolase (PARG), which plays important roles in DNA damage repair.
Eva Janisiw, Marilina Raices, F. Balmir, Luis F Paulin, A. Baudrimont, A. von Haeseler, J. Yanowitz, Verena Jantsch, Nicola Silva   +8 more
semanticscholar   +1 more source

Poly(ADP-ribose) glycohydrolase promotes formation and homology-directed repair of meiotic DNA double-strand breaks independent of its catalytic activity

bioRxiv, 2020
Poly(ADP-ribosyl)ation is a reversible post-translational modification synthetized by ADP-ribose transferases and removed by poly(ADP-ribose) glycohydrolase (PARG), which plays important roles in DNA damage repair.
Eva Janisiw, Marilina Raices, F. Balmir, Luis Felipe Paulin Paz, A. Baudrimont, A. von Haeseler, J. Yanowitz, Verena Jantsch, Nicola Silva   +8 more
semanticscholar   +1 more source