The FASEB Journal, 2023 Abstract Ischemic stroke is known to cause the accumulation of misfolded proteins and loss of calcium homeostasis, leading to impairment of endoplasmic reticulum (ER) function and activating the unfolded protein response (UPR). PARP16 is an active (ADP‐ribosyl)transferase known tail‐anchored ER transmembrane protein with a cytosolic ...
Jinghuan Wang +6 more
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Investigation of the action of poly(ADP-ribose)-synthesising enzymes on NAD+ analogues
Beilstein Journal of Organic Chemistry, 2017 ADP-ribosyl transferases with diphtheria toxin homology (ARTDs) catalyse the covalent addition of ADP-ribose onto different acceptors forming mono- or poly(ADP-ribos)ylated proteins. Out of the 18 members identified, only four are known to synthesise the
Edward L Simpson, Andreas Marx
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PARylation-mediated post-transcriptional modifications in cancer immunity and immunotherapy [PDF]
Frontiers in ImmunologyPoly-ADP-ribosylation (PARylation) is a post-translational modification in which ADP-ribose is added to substrate proteins. PARylation is mediated by a superfamily of ADP-ribosyl transferases known as PARPs and influences a wide range of cellular ...
Kazuya Matsumoto +2 more
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Adenosine diphosphate-ribosylation greatly affects proteins function: a focus on neurodegenerative diseases [PDF]
Frontiers in Aging NeuroscienceAdenosine diphosphate-ribosylation (ADPRylation) is a reversible posttranslational modification that plays a crucial role in cellular homeostasis and disease development.
Chaowen Huang +8 more
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Mono-ADP-ribosylation, a MARylationmultifaced modification of protein, DNA and RNA: characterizations, functions and mechanisms [PDF]
Cell Death DiscoveryThe functional alterations of proteins and nucleic acids mainly rely on their modifications. ADP-ribosylation is a NAD+-dependent modification of proteins and, in some cases, of nucleic acids.
Hao Wu +5 more
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Influence of spermine and histones on a nuclear nucleosidase with ADP‐ribose transferase activity in ehrlich ascites cells [PDF]
FEBS Letters, 1968 Karl Walter Bock, V. Gäng
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PARP7 as a new target for activating anti-tumor immunity in cancer [PDF]
EMBO Molecular MedicineADP-ribosyl transferases (ARTs) are a family of enzymes which catalyze the addition of a chain (PARylation) or a single moiety (MARylation) of ADP-ribose to their substrates.
Katerina Popova +7 more
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Biallelic ADPRHL2 mutations in complex neuropathy affect ADP ribosylation and DNA damage response
Life Science Alliance, 2021 This work studies known and new ADPRHL2 mutations with different disease mechanisms overall indicating that loss of nuclear ARH3 alone is pathogenic via dysregulated nuclear ADP ribosylation.
Danique Beijer +10 more
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Computational and Structural Biotechnology Journal, 2022 ADP-ribosylation is an ancient, highly conserved, and reversible covalent modification critical for a variety of endogenous processes in both prokaryotes and eukaryotes.
Andrea Hloušek-Kasun +9 more
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ADP-Ribosylation and Antiviral Resistance in Plants
Viruses, 2023 ADP-ribosylation (ADPRylation) is a versatile posttranslational modification in eukaryotic cells which is involved in the regulation of a wide range of key biological processes, including DNA repair, cell signalling, programmed cell death, growth and ...
Nadezhda Spechenkova +4 more
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