Results 1 to 10 of about 10,497 (180)

Bacterial Exotoxins and the Inflammasome [PDF]

Frontiers in Immunology, 2015
The inflammasomes are intracellular protein complexes that play an important role in innate immune sensing. Activation of inflammasomes leads to activation of caspase-1 and maturation and secretion of the pro-inflammatory cytokines IL-1β and IL-18.
Stephen Leppla, Allison J Greaney, Mahtab Moayeri   +2 more
exaly   +5 more sources

14-3-3 Activated Bacterial Exotoxins AexT and ExoT Share Actin and the SH2 Domains of CRK Proteins as Targets for ADP-Ribosylation

Pathogens, 2022
Bacterial exotoxins with ADP-ribosyltransferase activity can be divided into distinct clades based on their domain organization. Exotoxins from several clades are known to modify actin at Arg177; but of the 14-3-3 dependent exotoxins only Aeromonas ...
Anders Hofer, Herwig Schüler, Saber Anoosheh   +2 more
exaly   +3 more sources

Exo-Tox: Identifying Exotoxins from secreted bacterial proteins [PDF]

BioData Mining
Background Bacterial exotoxins are secreted proteins able to affect target cells, and associated with diseases. Their accurate identification can enhance drug discovery and ensure the safety of bacteria-based medical applications.
Tanja Krueger, Damla A. Durmaz, Luisa F. Jimenez-Soto   +2 more
doaj   +2 more sources

Genetic and Phenotypic Characteristics of Five Staphylococcus aureus Strains Isolated from Yakutian Cattle [PDF]

Animals
To date, the problem of mastitis in cattle remains relevant for both the industrial sector and scientific research. Despite numerous active investigations, the causes of this disease have not been fully established.
Ksenia Fursova, Daria Nikanova, Sergei Sokolov, Daria Sherman, Olga Artem’eva, Evgenia Kolodina, Anna Tiurina, Anatoly Sorokin, Timur Dzhelyadin, Varvara Romanova, Margarita Shchannikova, Andrei Pochtovyi, Vladimir Gushchin, Artem Ermakov, Natalia Zinovieva, Fedor Brovko   +15 more
doaj   +2 more sources

Two homologous sequences of Grp78 and HSP70 represent tumor antigens shared with streptococcal superantigens in eliciting an antitumor immune response: an immunoinformatic investigation [PDF]

Frontiers in Immunology
Bacteria-based therapies have gained increasing attention as novel immunotherapeutic approaches against tumors. Among them, bacteria producing superantigen (SAg) toxins are considered particularly effective due to their ability to induce potent ...
Paola Finotti
doaj   +2 more sources

Case Report: Fatal case of dual infection Metapneumovirus complicated by Streptococcus pyogenes [PDF]

Frontiers in Medicine
Human Metapneumovirus (hMPV) is a common cause of acute respiratory viral infection in humans, typically occurring in children and causing no serious complications.
Danil Krivonos, Danil Krivonos, Alexander Pavlenko, Alexandra Lukina-Gronskaya, Elena Korneenko, Elena Korneenko, Anna Speranskaya, Elena Ilina   +7 more
doaj   +2 more sources

Comparison of genotyping methods and toxin gene profiles of Staphylococcus aureus isolates from clinical specimens [PDF]

Genetics and Molecular Biology, 2023
Staphylococcus aureus is a frequent cause of infections worldwide. Methicillin-resistant S. aureus (MRSA) is one of the main causes of Gram-positive infections, and methicillin-susceptible strains (MSSA) primarily colonize and infect community hosts ...
Mariana Andrade-Figueiredo, Ana Carolina de Oliveira Luz, Vladimir da Mota Silveira Filho, Tereza Cristina Leal-Balbino   +3 more
doaj   +1 more source

Functional and Immunological Studies Revealed a Second Superantigen Toxin in Staphylococcal Enterotoxin C Producing Staphylococcus aureus Strains

Toxins, 2022
Staphylococcus aureus is a human and animal pathogen as well as a commensal bacterium. It can be a causative agent of severe, life-threatening infections with high mortality, e.g., toxic shock syndrome, septic shock, and multi-organ failure. S.
Andreas Roetzer, Nina Model, Jakob Laube, Yvonne Unterhumer, Guenter Haller, Martha M. Eibl   +5 more
doaj   +1 more source

Protection Efficacy of Oral Bait Probiotic Vaccine Constitutively Expressing Tetravalent Toxoids against Clostridium perfringens Exotoxins in Livestock (Rabbits)

Vaccines, 2020
Clostridium perfringens is an opportunistic pathogen. Its main virulence factors are exotoxins, which are the etiological agents of enteritis necroticans and enterotoxemia caused in livestock (cattle, sheep, and rabbits).
Jing Bai, Xinyuan Qiao, Yingying Ma, Meijing Han, Shuo Jia, Xinning Huang, Bing Han, Li Wang, Yijing Li, Yigang Xu   +9 more
doaj   +1 more source

Screening for Antimicrobial Resistance and Genes of Exotoxins in Pseudomonas aeruginosa Isolates from Infected Dogs and Cats in Poland

Antibiotics, 2023
Pseudomonas aeruginosa has assumed an increasingly prominent role as the aetiological agent in serious hard-to-treat infections in animals and humans. In this study, 271 P. aeruginosa strains collected from dogs and cats were investigated. The aim of the
Daria Płókarz, Karolina Bierowiec, Krzysztof Rypuła   +2 more
doaj   +1 more source