Proinflammatory synergy between protease and superantigen streptococcal pyogenic exotoxins [PDF]
Infection and ImmunityStreptococcal pyogenic exotoxins (Spe proteins) secreted by Streptococcus pyogenes (group A Streptococcus, GAS) are responsible for scarlet fever and streptococcal toxic shock syndrome.
Anders F. Johnson +5 more
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Acta Agriculturae Slovenica, 1998 Superantigens are bacterial, viral, retroviral and some naturally occurring proteins that can specifically activate a large proportion of T and/or B cells.
Mojca NARAT
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Ibrutinib enhances the bias of T cell responses towards staphylococcal superantigens sustaining inflammation in chronic lymphocytic leukaemia [PDF]
Frontiers in ImmunologyChronic lymphocytic leukaemia (CLL) is an uncurable haematological malignancy and is associated with significant infection morbidity. Bruton’s tyrosine-kinase inhibitors (e.g., ibrutinib) have improved disease outcomes, but severe infections and poor ...
Fisal Tantoush +5 more
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Two homologous sequences of Grp78 and HSP70 represent tumor antigens shared with streptococcal superantigens in eliciting an antitumor immune response: an immunoinformatic investigation [PDF]
Frontiers in ImmunologyBacteria-based therapies have gained increasing attention as novel immunotherapeutic approaches against tumors. Among them, bacteria producing superantigen (SAg) toxins are considered particularly effective due to their ability to induce potent ...
Paola Finotti
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Superantigen Recognition and Interactions: Functions, Mechanisms and Applications
Frontiers in Immunology, 2021 Superantigens are unconventional antigens which recognise immune receptors outside their usual recognition sites e.g. complementary determining regions (CDRs), to elicit a response within the target cell.
Anthony M. Deacy +3 more
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Superantigens increase the survival of mice bearing T cell lymphomas by inducing apoptosis of neoplastic cells. [PDF]
PLoS ONE, 2010 Superantigens bind to major histocompatibility complex class II molecules and interact with T cells expressing a particular T cell receptor Vβ inducing a strong proliferation/deletion response of the superantigen-reactive T cells.
Juliana Mundiñano +5 more
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Peptidoglycan Contribution to the B Cell Superantigen Activity of Staphylococcal Protein A
mBio, 2021 Staphylococcus aureus causes reiterative and chronic persistent infections. This can be explained by the formidable ability of this pathogen to escape immune surveillance mechanisms. Cells of S. aureus display the abundant staphylococcal protein A (SpA).
Miaomiao Shi +4 more
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Experimental Dermatology, 1996 Abstract Superantigens are potent modulators of the immune system. Some of their biological and immunological properties are reviewed here with special attention to their potential significance for cutaneous inflammation, specific skin immune responses and skin diseases.
J, Saloga, E W, Gelfand, J, Knop
openaire +2 more sources
Streptococcal superantigens and the return of scarlet fever.
PLoS Pathogens, 2021 Streptococcus pyogenes (group A Streptococcus) is a globally disseminated and human-adapted bacterial pathogen that causes a wide range of infections, including scarlet fever. Scarlet fever is a toxin-mediated disease characterized by the formation of an
Jacklyn R Hurst +3 more
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