Interference of the T cell and antigen-presenting cell costimulatory pathway using CTLA4-Ig (abatacept) prevents Staphylococcal enterotoxin B pathology [PDF]
, 2017 Staphylococcal enterotoxin B (SEB) is a bacterial superantigen that binds the receptors in the APC/T cell synapse and causes increased proliferation of T cells and a cytokine storm syndrome in vivo.
Carter, Alun J +10 more
core +2 more sources
Role of CD44 and its v7 isoform in staphylococcal enterotoxin B-induced toxic shock : CD44 deficiency on hepatic mononuclear cells leads to reduced activation-induced apoptosis that results in increased liver damage [PDF]
, 2005 Exposure to bacterial superantigens such as staphylococcal enterotoxin B (SEB) leads to the induction of toxic shock syndrome which results in multiorgan failure, including liver damage.
McKallip, R. J. +5 more
core +1 more source
South African Journal of Science, 2023 Staphylococcus aureus is a prominent pathogen that causes serious community and hospital-acquired infections globally. Its pathogenicity is attributed to a variety of secreted and cell surface associated proteins that are modulated by the quorum-sensing
Nkechi V. Enwuru +3 more
doaj +1 more source
Indian Journal of Dermatology, 2012 Background: There is great disagreement regarding which effector T-cells are responsible for the pathogenesis of systemic sclerosis. Further, the possible role of superantigens in modulating the T-cell phenotype responsible for the immunopathogenesis of ...
Sajad Ahmad Dar +5 more
doaj +1 more source
Endogenous Superantigens Shape Response to Exogenous Superantigens [PDF]
Clinical and Vaccine Immunology, 2005 ABSTRACT Endogenous superantigen-mediated thymic negative selection resulted in a paucity of mature T cells bearing T-cell receptor (TCR) Vβ8 in the periphery. Consequently, the magnitude of immune response to exogenous superantigen staphylococcal enterotoxin B, which activates TCR Vβ8 + T cells, was ...
Govindarajan, Rajagopalan +5 more
openaire +2 more sources
Toxins, 2019 Necrotizing soft tissue infections (NSTIs) are critical clinical conditions characterized by extensive necrosis of any layer of the soft tissue and systemic toxicity. Group A streptococci (GAS) and Staphylococcus aureus are two major pathogens associated
Patience Shumba +2 more
doaj +1 more source
Food Poisoning and Staphylococcus aureus Enterotoxins
Toxins, 2010 Staphylococcus aureus produces a wide variety of toxins including staphylococcal enterotoxins (SEs; SEA to SEE, SEG to SEI, SER to SET) with demonstrated emetic activity, and staphylococcal-like (SEl) proteins, which are not emetic in a primate model ...
María Rosario Rodicio +2 more
doaj +1 more source
Phosphatidylinositol 3-kinase improves the efficiency of positive selection [PDF]
, 2006 We have generated transgenic mice expressing the amino-terminal fragment of the phosphatidylinositol 3-kinase (PI3K) catalytic subunit (p110(ABD)) in thymocytes.
Alberola-Ila, José, Barbee, Susannah D.
core +1 more source
MAIT cells launch a rapid, robust and distinct hyperinflammatory response to bacterial superantigens and quickly acquire an anergic phenotype that impedes their cognate antimicrobial function: Defining a novel mechanism of superantigen-induced immunopathology and immunosuppression [PDF]
, 2017 Superantigens (SAgs) are potent exotoxins secreted by Staphylococcus aureus and Streptococcus pyogenes. They target a large fraction of T cell pools to set in motion a "cytokine storm" with severe and sometimes life-threatening consequences typically ...
A Kurioka +81 more
core +4 more sources
Toxins, 2010 Staphylococcus aureus (S. aureus) is a Gram positive bacterium that is carried by about one third of the general population and is responsible for common and serious diseases.
Victor E. Reyes +2 more
doaj +1 more source