Results 21 to 30 of about 9,440 (204)

Superantigens, a Paradox of the Immune Response [PDF]

, 2022
Staphylococcal enterotoxins are a wide family of bacterial exotoxins with the capacity to activate as much as 20% of the host T cells, which is why they were called superantigens.
Malchiodi, Emilio Luis, Fernández, Marisa Mariel, Emilio Luis Malchiodi, Sofia Noli Truant, Redolfi, Daniela María, María Belén Sarratea, Daniela María Redolfi, Noli Truant, Sofia, Marisa Mariel Fernández, Sarratea, María Belén   +9 more
core   +1 more source

Endogenous Superantigens Shape Response to Exogenous Superantigens [PDF]

Clinical and Vaccine Immunology, 2005
ABSTRACT Endogenous superantigen-mediated thymic negative selection resulted in a paucity of mature T cells bearing T-cell receptor (TCR) Vβ8 in the periphery. Consequently, the magnitude of immune response to exogenous superantigen staphylococcal enterotoxin B, which activates TCR Vβ8 + T cells, was ...
Govindarajan, Rajagopalan, Manisha, Singh, Moon M, Sen, Narayana S, Murali, Karl A, Nath, Chella S, David   +5 more
openaire   +2 more sources

Response of T-cell subpopulations to superantigen and recall antigen stimulation in systemic sclerosis

Indian Journal of Dermatology, 2012
Background: There is great disagreement regarding which effector T-cells are responsible for the pathogenesis of systemic sclerosis. Further, the possible role of superantigens in modulating the T-cell phenotype responsible for the immunopathogenesis of ...
Sajad Ahmad Dar, Sambit Nath Bhattacharya, Shukla Das, Vishnampettai Ganapathysubramanian Ramachandran, Basu Dev Banerjee, Prateek Arora   +5 more
doaj   +1 more source

Viral Superantigens [PDF]

Mikrobiyoloji Bulteni, 2016
Superantigens (SAgs) are microbial proteins produced by various microorganisms that elicit excessive and strong stimulation of T cells via an unconventional mechanism. They cause polyclonal activation of T cells in a non-specific manner, by binding to a particular variable-beta (Vβ) chain of T-cell receptor (TCR) and MHC class II molecule, in ...
openaire   +3 more sources

The Role of Streptococcal and Staphylococcal Exotoxins and Proteases in Human Necrotizing Soft Tissue Infections

Toxins, 2019
Necrotizing soft tissue infections (NSTIs) are critical clinical conditions characterized by extensive necrosis of any layer of the soft tissue and systemic toxicity. Group A streptococci (GAS) and Staphylococcus aureus are two major pathogens associated
Patience Shumba, Srikanth Mairpady Shambat, Nikolai Siemens   +2 more
doaj   +1 more source

Food Poisoning and Staphylococcus aureus Enterotoxins

Toxins, 2010
Staphylococcus aureus produces a wide variety of toxins including staphylococcal enterotoxins (SEs; SEA to SEE, SEG to SEI, SER to SET) with demonstrated emetic activity, and staphylococcal-like (SEl) proteins, which are not emetic in a primate model ...
María Rosario Rodicio, María Carmen Mendoza, María Ángeles Argudín   +2 more
doaj   +1 more source

Superantigenic Activity of emm3 Streptococcus pyogenes Is Abrogated by a Conserved, Naturally Occurring smeZ Mutation [PDF]

, 2012
Streptococcus pyogenes M/emm3 strains have been epidemiologically linked with enhanced infection severity and risk of streptococcal toxic shock syndrome (STSS), a syndrome triggered by superantigenic stimulation of T cells. Comparison of S.
McGregor, Karen, Davies, F.J., Frances J Davies, Chong, Deborah L. W., McGregor, K., Davies, Frances J., McGregor, K, Leili Farzaneh, Spratt, BG, Leili Farzaneh (130255), Pichon, B., Shiranee Sriskandan, Efstratiou, A, McGregor Karen, Bruno Pichon (130249), Pichon, B, Holden, Matthew T. G., Davies, FJ, Mary Sommerlad, Androulla Efstratiou, Turner, CE, Sommerlad, M, Chong, DLW, Sriskandan Shiranee, Mary Sommerlad (130242), Sommerlad, M., Turner Claire E., Farzaneh, L., Brian G Spratt, Deborah L. W. Chong (130252), Brian G. Spratt (10001), Sriskandan, Shiranee, Holden, M.T., Holden, MTG, Matthew T G Holden, Sriskandan, S., Androulla Efstratiou (130260), Sommerlad Mary, Matthew T. G. Holden (130258), Pichon Bruno, Frances J. Davies (130247), Spratt, B.G., Shiranee Sriskandan (16154), Holden Matthew T. G., Karen McGregor (130245), Chong Deborah L. W., Turner, C.E., Karen McGregor, Sommerlad, Mary, Farzaneh, L, Sriskandan, S, Claire E Turner, Davies Frances J., Pichon, Bruno, Efstratiou, A., Farzaneh, Leili, Spratt Brian G., Claire E. Turner (130239), Spratt, Brian G., Efstratiou, Androulla, Efstratiou Androulla, Chong, D.L., Deborah L W Chong, Bruno Pichon, Farzaneh Leili, Turner, Claire E.   +65 more
core   +1 more source

Staphylococcal Enterotoxins

Toxins, 2010
Staphylococcus aureus (S. aureus) is a Gram positive bacterium that is carried by about one third of the general population and is responsible for common and serious diseases.
Victor E. Reyes, Ellen J. Beswick, Irina V. Pinchuk   +2 more
doaj   +1 more source

Superantigens as immunomodulators: recent structural insights [PDF]

, 1997
Superantigens interact with major histocompatibility complex (MHC) class II molecules and T-cell receptors (TcRs) forming a trimolecular complex which is able to induce proliferation and cytokine production in T cells.
Papageorgiou, Anastassios C, Acharya, K Ravi   +1 more
core   +1 more source

Superantigens: structure-function relationships

, 2004
Superantigens are a class of highly potent immuno-stimulatory molecules produced by Staphylococcus aureus and Streptococcus pyogenes. These toxins possess the unique ability to interact simultaneously with MHC class II molecules and T-cell receptors ...
K. Ravi Acharya, Acharya, K. Ravi, Acharya KR, Baker MD, Baker, Matthew Douglas, Matthew D. Baker   +5 more
core   +1 more source