Results 11 to 20 of about 13,743 (223)
Novel Tissue Level Effects of the Staphylococcus aureus Enterotoxin Gene Cluster Are Essential for Infective Endocarditis. [PDF]
PLoS ONE, 2016 Superantigens are indispensable virulence factors for Staphylococcus aureus in disease causation. Superantigens stimulate massive immune cell activation, leading to toxic shock syndrome (TSS) and contributing to other illnesses.
Christopher S Stach +6 more
doaj +1 more source
Human Keratinocyte Response to Superantigens
mSphere, 2020 Staphylococcus aureus and Streptococcus pyogenes are significant human pathogens, causing infections at multiple body sites, including across the skin. Both are organisms that cause human diseases and secrete superantigens, including toxic shock syndrome
Patrick M. Schlievert +3 more
doaj +1 more source
Pathogens, 2022 It has been posited SARS-CoV-2 contains at least one unique superantigen-like motif not found in any other SARS or endemic coronaviruses. Superantigens are potent antigens that can send the immune system into overdrive.
Adam Hamdy, Anthony Leonardi
doaj +1 more source
Atopic Dermatitis Host and Environment Model: Revisiting Therapeutic Options [PDF]
, 2020 Atopic Dermatitis affects both children and adults and is a serious health concern in many countries. AD is a complex disease with host and environmental factors underlying its pathology. Its treatment is multidimensional reflecting the diverse nature of
Abreu, C +3 more
core +1 more source
Infectious diseases and autoimmunity [PDF]
, 2011 Introduction: Autoimmunity occurs when the immune system recognizes and attacks host tissue. In addition to genetic factors, environmental triggers (in particular viruses, bacteria and other infectious pathogens) are thought to play a major role in the ...
Deidda, Silvia +3 more
core +1 more source
Superantigens, superantigen-like proteins and superantigen derivatives for cancer treatment.
European review for medical and pharmacological sciences, 2021 Bacterial superantigens (SAgs) are proteins produced by few types of bacteria that have been linked to several human diseases. Due to their potent in vitro and in vivo tumoricidal effects, they are extensively investigated for oncological applications either alone or in combination with classical anticancer drugs.
openaire +2 more sources
Enhanced nasopharyngeal infection and shedding associated with an epidemic lineage of emm3 group A Streptococcus [PDF]
, 2017 Background: A group A Streptococcus (GAS) lineage of genotype emm3, sequence type 15 (ST15) was associated with a six month upsurge in invasive GAS disease in the UK.
Afshar, B +8 more
core +3 more sources
Frontiers in Immunology, 2020 Chimeric antigen receptor T cell (CART) therapy, administration of certain T cell-agonistic antibodies, immune check point inhibitors, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) and Toxic ...
Shiv D. Kale +14 more
doaj +1 more source
Frontiers in Immunology, 2019 Staphylococcal and streptococcal superantigens are virulence factors that cause toxic shock by hyperinducing inflammatory cytokines. Effective T-cell activation requires interaction between the principal costimulatory receptor CD28 and its two coligands,
Andrey Popugailo +4 more
doaj +1 more source
Staphylococcus aureus enterotoxin B regulates prostaglandin E-2 synthesis, growth, and migration in nasal tissue fibroblasts [PDF]
, 2008 Background. Superantigens and eicosanoids are important amplifiers and regulators of inflammation in airway diseases. We therefore studied the possible influence of Staphylococcus aureus enterotoxin B ( SEB) on the cyclooxygenase ( COX) pathway and basic
Bachert, Claus +4 more
core +2 more sources