Results 11 to 20 of about 7,221 (174)

Human Keratinocyte Response to Superantigens

mSphere, 2020
Staphylococcus aureus and Streptococcus pyogenes are significant human pathogens, causing infections at multiple body sites, including across the skin. Both are organisms that cause human diseases and secrete superantigens, including toxic shock syndrome
Patrick M. Schlievert, Francoise A. Gourronc, Donald Y. M. Leung, Aloysius J. Klingelhutz   +3 more
doaj   +1 more source

Superantigens and SARS-CoV-2

Pathogens, 2022
It has been posited SARS-CoV-2 contains at least one unique superantigen-like motif not found in any other SARS or endemic coronaviruses. Superantigens are potent antigens that can send the immune system into overdrive.
Adam Hamdy, Anthony Leonardi
doaj   +1 more source

Accessory gene regulators and virulence genes associated with the pathogenicity of Staphylococcus aureus from clinical and community settings in Lagos, Nigeria

South African Journal of Science, 2023
Staphylococcus aureus is a prominent pathogen that causes serious community and hospital-acquired infections globally. Its pathogenicity is attributed to a variety of secreted and cell surface associated proteins that are modulated by the quorum-sensing
Nkechi V. Enwuru, Solayide A. Adesida, Christian A. Enwuru, Udoma E. Mendie   +3 more
doaj   +1 more source

Superantigens, superantigen-like proteins and superantigen derivatives for cancer treatment.

European review for medical and pharmacological sciences, 2021
Bacterial superantigens (SAgs) are proteins produced by few types of bacteria that have been linked to several human diseases. Due to their potent in vitro and in vivo tumoricidal effects, they are extensively investigated for oncological applications either alone or in combination with classical anticancer drugs.
openaire   +2 more sources

“Small” Intestinal Immunopathology Plays a “Big” Role in Lethal Cytokine Release Syndrome, and Its Modulation by Interferon-γ, IL-17A, and a Janus Kinase Inhibitor

Frontiers in Immunology, 2020
Chimeric antigen receptor T cell (CART) therapy, administration of certain T cell-agonistic antibodies, immune check point inhibitors, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) and Toxic ...
Shiv D. Kale, Brittney N. Mehrkens, Molly M. Stegman, Bridget Kastelberg, Henry Carnes, Rachel J. McNeill, Amy Rizzo, Saikumar V. Karyala, Sheryl Coutermarsh-Ott, Jackie A. Fretz, Ying Sun, Jonathan L. Koff, Govindarajan Rajagopalan, Govindarajan Rajagopalan, Govindarajan Rajagopalan   +14 more
doaj   +1 more source

Staphylococcal and Streptococcal Superantigens Trigger B7/CD28 Costimulatory Receptor Engagement to Hyperinduce Inflammatory Cytokines

Frontiers in Immunology, 2019
Staphylococcal and streptococcal superantigens are virulence factors that cause toxic shock by hyperinducing inflammatory cytokines. Effective T-cell activation requires interaction between the principal costimulatory receptor CD28 and its two coligands,
Andrey Popugailo, Ziv Rotfogel, Emmanuelle Supper, Dalia Hillman, Raymond Kaempfer   +4 more
doaj   +1 more source

Response of T-cell subpopulations to superantigen and recall antigen stimulation in systemic sclerosis

Indian Journal of Dermatology, 2012
Background: There is great disagreement regarding which effector T-cells are responsible for the pathogenesis of systemic sclerosis. Further, the possible role of superantigens in modulating the T-cell phenotype responsible for the immunopathogenesis of ...
Sajad Ahmad Dar, Sambit Nath Bhattacharya, Shukla Das, Vishnampettai Ganapathysubramanian Ramachandran, Basu Dev Banerjee, Prateek Arora   +5 more
doaj   +1 more source

Endogenous Superantigens Shape Response to Exogenous Superantigens [PDF]

Clinical and Vaccine Immunology, 2005
ABSTRACT Endogenous superantigen-mediated thymic negative selection resulted in a paucity of mature T cells bearing T-cell receptor (TCR) Vβ8 in the periphery. Consequently, the magnitude of immune response to exogenous superantigen staphylococcal enterotoxin B, which activates TCR Vβ8 + T cells, was ...
Govindarajan, Rajagopalan, Manisha, Singh, Moon M, Sen, Narayana S, Murali, Karl A, Nath, Chella S, David   +5 more
openaire   +2 more sources

The Role of Streptococcal and Staphylococcal Exotoxins and Proteases in Human Necrotizing Soft Tissue Infections

Toxins, 2019
Necrotizing soft tissue infections (NSTIs) are critical clinical conditions characterized by extensive necrosis of any layer of the soft tissue and systemic toxicity. Group A streptococci (GAS) and Staphylococcus aureus are two major pathogens associated
Patience Shumba, Srikanth Mairpady Shambat, Nikolai Siemens   +2 more
doaj   +1 more source

Food Poisoning and Staphylococcus aureus Enterotoxins

Toxins, 2010
Staphylococcus aureus produces a wide variety of toxins including staphylococcal enterotoxins (SEs; SEA to SEE, SEG to SEI, SER to SET) with demonstrated emetic activity, and staphylococcal-like (SEl) proteins, which are not emetic in a primate model ...
María Rosario Rodicio, María Carmen Mendoza, María Ángeles Argudín   +2 more
doaj   +1 more source