Results 11 to 20 of about 9,440 (204)

Superantigens in Cancer Immunotherapy: Mechanisms, Engineering Strategies, and Therapeutic Potential. [PDF]

FASEB J
Schematic overview of superantigen‐mediated antitumor immune responses and immune suppression within the tumor microenvironment. (1) Antigen‐presenting cells activate T cells through MHC‐II/TCR interactions resulting in the production of cytokines (2) The pro‐inflammatory cytokines released by activated immune cells stimulate downstream immune ...
Virk UY, Malik HA, Anwer M, Wilson J, Rahi MS, Wei MQ.   +5 more
europepmc   +3 more sources

Staphylococcal and Streptococcal Superantigens Trigger B7/CD28 Costimulatory Receptor Engagement to Hyperinduce Inflammatory Cytokines [PDF]

Frontiers in Immunology, 2019
Staphylococcal and streptococcal superantigens are virulence factors that cause toxic shock by hyperinducing inflammatory cytokines. Effective T-cell activation requires interaction between the principal costimulatory receptor CD28 and its two coligands,
Andrey Popugailo, Ziv Rotfogel, Emmanuelle Supper, Dalia Hillman, Raymond Kaempfer   +4 more
doaj   +2 more sources

HLA Class II Polymorphisms Determine Responses to Bacterial Superantigens

, 2004
The excessive immunological response triggered by microbial superantigens has been implicated in the etiology of a wide range of human diseases but has been most clearly defined for the staphylococcal and streptococcal toxic shock syndromes.
Martin Llewelyn (6946376), Llewelyn, M, Ambrozak, D R, Daniel M. Altmann, David R. Ambrozak, Jonathan Cohen, Daniel C. Douek, David R Ambrozak (16232207), Mark Peakman, Martin Llewelyn, Shiranee Sriskandan (16154), William W Kwok (16232213), Kwok, W W, Jonathan Cohen (26835), Cohen, J, Peakman, M; id_orcid, Daniel C Douek (16232210), Daniel M Altmann (16232216), Altmann, D M, Sriskandan, S, Shiranee Sriskandan, Mark Peakman (5429330), William W. Kwok, Douek, D C   +23 more
core   +7 more sources

Human Keratinocyte Response to Superantigens

mSphere, 2020
Staphylococcus aureus and Streptococcus pyogenes are significant human pathogens, causing infections at multiple body sites, including across the skin. Both are organisms that cause human diseases and secrete superantigens, including toxic shock syndrome
Patrick M. Schlievert, Francoise A. Gourronc, Donald Y. M. Leung, Aloysius J. Klingelhutz   +3 more
doaj   +1 more source

Superantigens and SARS-CoV-2

Pathogens, 2022
It has been posited SARS-CoV-2 contains at least one unique superantigen-like motif not found in any other SARS or endemic coronaviruses. Superantigens are potent antigens that can send the immune system into overdrive.
Adam Hamdy, Anthony Leonardi
doaj   +1 more source

Accessory gene regulators and virulence genes associated with the pathogenicity of Staphylococcus aureus from clinical and community settings in Lagos, Nigeria

South African Journal of Science, 2023
Staphylococcus aureus is a prominent pathogen that causes serious community and hospital-acquired infections globally. Its pathogenicity is attributed to a variety of secreted and cell surface associated proteins that are modulated by the quorum-sensing
Nkechi V. Enwuru, Solayide A. Adesida, Christian A. Enwuru, Udoma E. Mendie   +3 more
doaj   +1 more source

Staphylococcus aureus superantigens in atopic dermatitis

, 2022
Source data in the study analyzing staphylococcal superantigens in 50 patients with atopic ...
Blicharz, L
core   +2 more sources

Selective Expansion of TCR Vβ2⁺ Tregs and Impaired Lymphocyte TSST-1 Responsiveness in Bullous Pemphigoid Patients Colonised by Staphylococcus aureus. [PDF]

Exp Dermatol
ABSTRACT Bullous pemphigoid (BP) is an autoimmune blistering disease of the elderly who are frequently colonised by Staphylococcus aureus, particularly strains producing the superantigen toxic shock syndrome toxin‐1 (TSST‐1). Given the ability of TSST‐1 to engage the T cell receptor (TCR) Vβ2 chain, we investigated whether superantigen (SAg) exposure ...
Chen TY, Crowe TP, Fakhimi M, Poleksíc M, Kilgore SH, Schlievert PM, Fairley JA, Messingham KN.   +7 more
europepmc   +2 more sources

Superantigens, superantigen-like proteins and superantigen derivatives for cancer treatment.

European review for medical and pharmacological sciences, 2021
Bacterial superantigens (SAgs) are proteins produced by few types of bacteria that have been linked to several human diseases. Due to their potent in vitro and in vivo tumoricidal effects, they are extensively investigated for oncological applications either alone or in combination with classical anticancer drugs.
openaire   +2 more sources

“Small” Intestinal Immunopathology Plays a “Big” Role in Lethal Cytokine Release Syndrome, and Its Modulation by Interferon-γ, IL-17A, and a Janus Kinase Inhibitor

Frontiers in Immunology, 2020
Chimeric antigen receptor T cell (CART) therapy, administration of certain T cell-agonistic antibodies, immune check point inhibitors, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) and Toxic ...
Shiv D. Kale, Brittney N. Mehrkens, Molly M. Stegman, Bridget Kastelberg, Henry Carnes, Rachel J. McNeill, Amy Rizzo, Saikumar V. Karyala, Sheryl Coutermarsh-Ott, Jackie A. Fretz, Ying Sun, Jonathan L. Koff, Govindarajan Rajagopalan, Govindarajan Rajagopalan, Govindarajan Rajagopalan   +14 more
doaj   +1 more source