Immunogenicity of Immunotoxins Containing Pseudomonas Exotoxin A: Causes, Consequences, and Mitigation [PDF]
Frontiers in Immunology, 2020 Immunotoxins are cytolytic fusion proteins developed for cancer therapy, composed of an antibody fragment that binds to a cancer cell and a protein toxin fragment that kills the cell.
Ronit Mazor, Ira Pastan
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Pseudomonas infection: exotoxin A effect [PDF]
Саратовский научно-медицинский журнал, 2014 The aim of the article is to present the data analysis of the Russian and foreign literature concerning the current situation of the problem, the frequency and mechanisms of pseudomonas infection development and factors of patho-genicity of Pseudomonas ...
Morrison A.V. +2 more
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Structural complementation of the catalytic domain of pseudomonas exotoxin A. [PDF]
J Mol Biol, 2014 The catalytic moiety of Pseudomonas exotoxin A (domain III or PE3) inhibits protein synthesis by ADP-ribosylation of eukaryotic elongation factor 2. PE3 is widely used as a cytocidal payload in receptor-targeted protein toxin conjugates. We have designed and characterized catalytically inactive fragments of PE3 that are capable of structural ...
Boland EL +4 more
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PCR based identification of exotoxin A-producing Pseudomonas aeroginosa isolated from burn wound infection [PDF]
Trends in Pharmaceutical Sciences, 2022 Exotoxin A (exoA) is a major pathogenic factor in Pseudomonas aeruginosa. This non-fermenting gram-negative bacillus causes a wide range of infections. P. aeruginosa is a major cause of hospital-acquired infections.
Gholamreza Morshedi +9 more
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Preparation and evaluation of the exotoxin A nano-gold conjugate as a vaccine candidate for Pseudomonas aeruginosa infections [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Objective(s): Pseudomonas aeruginosa is an opportunistic pathogen that is an important cause of nosocomial infections. This bacterium produces various virulence factors, among which exotoxin A is significantly involved in mortality and morbidity. In this
Masoumeh Abbasi +4 more
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ISOLATION AND PURIFICATION OF ANTICANCER PROTEIN EXOTXIN A FROM Pseudomonas aeruginosa
The Iraqi Journal of Agricultural science, 2022 Toxins produced from bacteria constitute promising antitumor agents in treating different cancer types. Exotoxin A from Pseudomonas aeruginosa is the highly toxic virulence component that bind to specific cell receptors.
L. Q. Jawad, H. A. R. R. Rasheed
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Rhus coriaria extracts inhibit quorum sensing related virulence and biofilm production in drug-resistant Pseudomonas aeruginosa recovered from burn wounds [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): Numerous studies have confirmed sumac’s ability to inhibit pathogens and even eradicate chronic drug-resistant infections. Current research was conducted to demonstrate the action of various sumac extracts at sub-inhibitory concentrations ...
Akhter Ahmed +2 more
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LINK BETWEEN SOME VIRULNCE FACTORS GENES AND ANTIBACTERIAL RESISTANCE OF PSEUDOMONAS AERUGINOSA
The Iraqi Journal of Agricultural science, 2022 The research was aimed to demonstrate the frequency of virulence factors genes (exoenzyme S and exotoxin A) and to express their relationship to antibacterial resistance among Pseudomonas aeruginosa isolated from patients suffering from otitis externa ...
Aida H. Ibrahim
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BMC Infectious Diseases, 2021 Background Pseudomonas aeruginosa is the leading cause of nosocomial infections, especially in people with a compromised immune system. Targeting virulence factors by neutralizing antibodies is a novel paradigm for the treatment of antibiotic-resistant ...
Zahra Shadman +6 more
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AMB Express, 2021 This work explores the ADP-ribosyltransferase activity of Pseudomonas (P.) aeruginosa exotoxin A using the guanyl hydrazone derivative, nitrobenzylidine aminoguanidine (NBAG) and the impact of gamma radiation on its efficacy.
Radwa N. Morgan +3 more
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