Results 31 to 40 of about 14,191 (208)
Multifaceted Interplay between Hfq and the Small RNA GssA in Pseudomonas aeruginosa
mBio, 2023 Behind the pathogenic lifestyle of Pseudomonas aeruginosa exists a complex regulatory network of intertwined switches at both the transcriptional and posttranscriptional levels.
Silvia Santoro +5 more
doaj +1 more source
Pseudomonas exotoxin: chimeric toxins
Journal of Biological Chemistry, 1989 Pseudomonas exotoxin binds to and enters cells by receptor-mediated endocytosis. Within the cell it requires exposure to low pH to enable it to translocate to the cell cytoplasm where it inhibits protein synthesis by ADP-ribosylating elongation factor 2.
I, Pastan, D, FitzGerald
openaire +2 more sources
Characterization of the insertion of Pseudomonas exotoxin A into membranes [PDF]
Infection and Immunity, 1985 Pseudomonas aeruginosa exotoxin A (PTx) is an extremely potent inhibitor of protein synthesis, similar to diphtheria toxin in its mode of action. It is synthesized in precursor form and secreted as an Mr 66,583 protein lacking a 25-amino acid leader sequence. While the primary sequence and the nature of the enzyme activity that leads to inactivation of
L S, Zalman, B J, Wisnieski
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The future of antiviral immunotoxins [PDF]
, 2016 There is a constant need for new therapeutic interventions in a wide range of infectious diseases. Over the past few years, the immunotoxins have entered the stage as promising antiviral treatments.
Høy Jakobsen, Mette +3 more
core +1 more source
Molecular studies of Pseudomonas exotoxin A gene [PDF]
Infection and Immunity, 1986 A 2.7-kilobase DNA fragment carrying the entire exotoxin A (ETA) structural gene was divided into three nonoverlapping probes. Two probes covering the ETA structural gene were used in colony hybridization experiments to determine whether sequences homologous to the ETA gene could be detected in genera other than Pseudomonas or in Pseudomonas species ...
M L, Vasil, C, Chamberlain, C C, Grant
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Exotoxin A Pseudomonas aeruginosa influence on working efficiency of white rats [PDF]
Саратовский научно-медицинский журнал, 2017 Objective: to study exotoxin A Pseudomonas aeruginosa influence on physical and mental efficiency of white rats. Material and Methods. The experiments were carried out on white rats following intraperitoneal injections of exotoxin A Pseudomonas of ...
Morrison V.V. +3 more
doaj
Novelty in Biomedicine, 2018 Background: Targeted cancer therapies have played a great role in the treatment of malignant tumors, in the recent years. Among these therapies, targeted toxin therapies such as immunotoxins, has improved the patient’s survival rate by minimizing the ...
Sahel Amoozadeh +4 more
doaj +1 more source
Candida albicans Inhibits Pseudomonas aeruginosa Virulence through Suppression of Pyochelin and Pyoverdine Biosynthesis. [PDF]
, 2015 Bacterial-fungal interactions have important physiologic and medical ramifications, but the mechanisms of these interactions are poorly understood.
Coughlin, L.A. +7 more
core +3 more sources
14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface
Nature Communications, 2018 The cellular toxicity of Pseudomonas exotoxin-S and -T depends on their activation by 14-3-3 but the underlying molecular mechanism is not fully understood.
Tobias Karlberg +16 more
doaj +1 more source
Syntaxin 16 and syntaxin 5 are required for efficient retrograde transport of several exogenous and endogenous cargo proteins [PDF]
, 2007 Retrograde transport allows proteins and lipids to leave the endocytic pathway to reach other intracellular compartments, such as trans-Golgi network (TGN)/Golgi membranes, the endoplasmic reticulum and, in some instances, the cytosol. Here, we have used
Amessou, Mohamed +7 more
core +3 more sources