Elevated Paracellular Glucose Flux across Cystic Fibrosis Airway Epithelial Monolayers Is an Important Factor for Pseudomonas aeruginosa Growth. [PDF]
, 2013 People with cystic fibrosis (CF) who develop related diabetes (CFRD) have accelerated pulmonary decline, increased infection with antibiotic-resistant Pseudomonas aeruginosa and increased pulmonary exacerbations.
James P Garnett +27 more
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Exotoxin-Targeted Drug Modalities as Antibiotic Alternatives
, 2022 The paradigm of antivirulence therapy dictates that bacterial pathogens are specifically disarmed but not killed by neutralizing their virulence factors. Clearance of the invading pathogen by the immune system is promoted. As compared to antibiotics, the
Moona Sakari (12024012) +5 more
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Preparation of PLGA (poly lactic-co-glycolic acid) nanoparticles Containing Pseudomonas aeruginosa Alginate, LPS and Exotoxin A as a Nano-vaccine [PDF]
Biological Journal of Microorganism, 2018 Introduction: Pseudomonas aeruginosa is a particular importance due to the numerous factors of pathogenicity and the prevalence of multi-resistance strains throughout the world.
Leila Safari zanjani +4 more
doaj +1 more source
Multifaceted Interplay between Hfq and the Small RNA GssA in Pseudomonas aeruginosa
mBio, 2023 Behind the pathogenic lifestyle of Pseudomonas aeruginosa exists a complex regulatory network of intertwined switches at both the transcriptional and posttranscriptional levels.
Silvia Santoro +5 more
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Molecular Detection of some Virulence Factors of Pseudomonas aeruginosa Isolated from Freshwater Fishes at Qalubiya Governorate, Egypt [PDF]
Benha Veterinary Medical Journal, 2023 The present study was conducted on 145 clinically diseased fish samples, 55 Nile tilapia; Oreochromus niloticus (O.niloticus); 65 African catfish (C. gariepinus), and 25 Grey mullet, Mugilcephalus (M. cephalus) of various sizes.
wedad Ahmed +3 more
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Pseudomonas exotoxin: chimeric toxins
Journal of Biological Chemistry, 1989 Pseudomonas exotoxin binds to and enters cells by receptor-mediated endocytosis. Within the cell it requires exposure to low pH to enable it to translocate to the cell cytoplasm where it inhibits protein synthesis by ADP-ribosylating elongation factor 2.
I, Pastan, D, FitzGerald
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Incidence of exotoxin production by Pseudomonas species [PDF]
Infection and Immunity, 1977 Pseudomonas aeruginosa exotoxin A has been shown to catalyze the transfer of the adenosine 5'-diphosphate (ADP)-ribose moiety of nicotinamide adenine dinucleotide onto elongation factor 2, resulting in the inhibition of mammalian protein synthesis.
M J, Bjorn +3 more
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14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface
Nature Communications, 2018 The cellular toxicity of Pseudomonas exotoxin-S and -T depends on their activation by 14-3-3 but the underlying molecular mechanism is not fully understood.
Tobias Karlberg +16 more
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Molecular studies of Pseudomonas exotoxin A gene [PDF]
Infection and Immunity, 1986 A 2.7-kilobase DNA fragment carrying the entire exotoxin A (ETA) structural gene was divided into three nonoverlapping probes. Two probes covering the ETA structural gene were used in colony hybridization experiments to determine whether sequences homologous to the ETA gene could be detected in genera other than Pseudomonas or in Pseudomonas species ...
M L, Vasil, C, Chamberlain, C C, Grant
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Characterization of the insertion of Pseudomonas exotoxin A into membranes [PDF]
Infection and Immunity, 1985 Pseudomonas aeruginosa exotoxin A (PTx) is an extremely potent inhibitor of protein synthesis, similar to diphtheria toxin in its mode of action. It is synthesized in precursor form and secreted as an Mr 66,583 protein lacking a 25-amino acid leader sequence. While the primary sequence and the nature of the enzyme activity that leads to inactivation of
L S, Zalman, B J, Wisnieski
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