Results 51 to 60 of about 113,972,927 (185)
Gasdermin‐Mediated Pyroptosis: Novel Strategies Against Colorectal Cancer
Cancer Science, Volume 117, Issue 8, Page 2064-2084, August 2026.Pyroptosis is a double‐edged sword in colorectal cancer (CRC): chronic low‐grade pyroptosis promotes tumor progression, whereas acute induction of pyroptosis in cancer cells triggers antitumor immunity and enhances therapeutic response. Targeting gasdermin‐mediated pyroptosis represents a promising strategy for CRC treatment.
Kaibo Guo +6 more
wiley +1 more source
Purification of Pseudomonas aeruginosa exotoxin by affinity chromatography [PDF]
Infection and Immunity, 1978 Pseudomonas aeruginosa exotoxin A was purified by affinity chromatography from culture supernatants by elution of toxin from antitoxin immunoglobulin G-Sepharose 4B with 3 M NaSCN. The purity, toxicity, and enzymatic activity of exotoxin obtained were comparable to those of toxin purified by previously reported multiple-step procedures.
N S, Taylor, M, Pollack
openaire +2 more sources
Human Vaccines & Immunotherapeutics, 2019 Antibodies are effective alternative tools to combat infections caused by Pseudomonas aeruginosa (PA), especially multi-drug-resistant PA. Thus, to solve the urgent need for an anti-PA antibody drug, we hypothesized that anti-PA intravenous ...
Jin Zhang +10 more
doaj +1 more source
Chemistry – A European Journal, Volume 32, Issue 26, 11 July 2026.The introduction outlines the review scope. Microbial cell factories as living drugs cover host–gut microbiota, bacteria, yeast, and other microbial systems, with comparative host advantages. Engineering strategies include synthetic circuits, quorum sensing, and memory.
Cemile Elif Özçelik +3 more
wiley +1 more source
Hybrid proteins between Pseudomonas exotoxin A and poliovirus protease 2Apro [PDF]
, 1994 Two hybrid proteins between Pseudomonas aeruginosa exotoxin A (PE) and poliovirus protease 2Apro have been generated. One hybrid protein contains the poliovirus 2Apro sequence replacing the region of PE corresponding to amino acids 413–607.
Elena Feduchi +5 more
core +1 more source
Identification of peptide inhibitors of Pseudomonas aeruginosa exotoxin A function [PDF]
, 2000 Pseudomonas aeruginosa' is an opportunistic pathogen that can cause lethal infections in immunocompromised hosts. It is resistant to a wide variety of antibiotics, thus new strategies are needed to control its pathogenicity.
Thompson, Crista
core +1 more source
Clinical Case Reports, Volume 14, Issue 7, July 2026.ABSTRACT Ischiorectal abscess can rarely progress beyond the anorectal region to cause Fournier's gangrene, supralevator extension, and purulent peritonitis. Early recognition of disease progression, prompt imaging, aggressive surgical source control, and multidisciplinary management are critical to reducing morbidity and mortality in this life ...
Hervé Tshikomba Mbuyamba +7 more
wiley +1 more source
Structure-activity relationships of an exotoxin of Pseudomonas aeruginosa [PDF]
Infection and Immunity, 1977 The relation of the structure of Pseudomonas aeruginosa exotoxin A (PA toxin) to its enzymatic activity (adenosine 5'-diphosphate-ribosyl transferase) in vitro and to its toxicity in vivo was examined. PA toxin is produced as a single polypeptide chain with a molecular weight of about 71,500.
M L, Vasil, D, Kabat, B H, Iglewski
openaire +2 more sources
Urologic Bacteriome: The Hero or the Villain in Prostate Cancer Onset, Progression, and Treatment?
Medicinal Research Reviews, Volume 46, Issue 4, Page 1111-1151, July 2026.ABSTRACT Prostate cancer (PCa) is the second most frequently diagnosed cancer in men worldwide and the fifth leading cause of cancer‐related mortality, presenting urgent unmet clinical needs in diagnosis and treatment. The recognition of the microbiome as a key factor in human health has prompted numerous studies, revealing an exciting new approach to ...
Lara R. S. Fonseca +6 more
wiley +1 more source
مجله دانشکده پزشکی اصفهان, 2012 Background: Pseudomonas aeruginosa (P. aeruginosa), a major gram-negative opportunistic nosocomial pathogen, is notoriously known because of its intrinsic and acquired multiple antibiotic resistances.
Massumeh Doosti +3 more
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