Results 81 to 90 of about 25,693 (232)

Features of exotoxin production of vaccine strains of anthrax pathogen for use in the veterinary industry

Ukrainian Journal of Veterinary Sciences
Exotoxins that produce vaccine strains of the anthrax pathogen are the main source of immunogenicity of anti-selective vaccines used in veterinary medicine.
H. Zaviriukha, I. Vyshnytska, U. Yanenko, N. Sorokina, T. Vasylieva   +4 more
doaj   +1 more source

Calmodulin in Complex with Proteins and Small Molecule Ligands: Operating with the Element of Surprise. Implications for Structure-Based Drug Design [PDF]

, 2009
Calmodulin plays a role in several life processes, its flexibility allows binding of a number of different ligands from small molecules to amphiphilic peptide helices and proteins. Through the diversity of its functions, it is quite difficult to find new
Keserű, György Miklós, Menyhárd, D.K., Náray-Szabó, Gábor   +2 more
core  

Use of single-chain antibody derivatives for targeted drug delivery [PDF]

, 2016
Single-chain antibodies (scFvs), which contain only the variable domains of full-length antibodies, are relatively small molecules that can be used for selective drug delivery.
Ahmadzadeh, V., Erfani-Moghadam, V., Jaliani, H.Z., Khalili, M., Safdari, Y., Zarei, V.   +5 more
core   +1 more source

Biopharmaceuticals for Cancer Treatment: An Update

Cancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Cancer is one of the most debilitating diseases, causing profound physical and psychological impacts on patients. The global number of cancer patients has been steadily rising over the last few decades. The development of effective cancer therapies remains the primary focus in life science research, requiring a precise understanding of ...
Anupom Deb Nath, Yousuf Alam, Afsana Mustak Mim, Maksuda Akter, Mohammad Abbas Gani, Khondaker Muhammad Khairul Alam, Md. Nur Alam   +6 more
wiley   +1 more source

Anthrax protective antigen is a calcium-dependent serine protease

Virulence, 2018
Bacillus anthracis secretes a three component exotoxin-complex, which contributes to anthrax pathogenesis. Formation of this complex starts with the binding of protective antigen (PA) to its cellular receptor.
Lisanne Storm, Floris J. Bikker, Kamran Nazmi, Albert G. Hulst, Debora V. der Riet-Van Oeveren, Enno C.I. Veerman, John P. Hays, Wendy E. Kaman   +7 more
doaj   +1 more source

Candida albicans Inhibits Pseudomonas aeruginosa Virulence through Suppression of Pyochelin and Pyoverdine Biosynthesis. [PDF]

, 2015
Bacterial-fungal interactions have important physiologic and medical ramifications, but the mechanisms of these interactions are poorly understood.
Coughlin, L.A., Fan, D., Ho, E.X., Hooper, L.V., Koh, A.Y., Lamont, I.L., Lopez-Medina, E., Reimmann, C.   +7 more
core   +3 more sources

Ultrastructural Mucosal Response to Dupilumab in Chronic Rhinosinusitis With Nasal Polyps: A Pilot Study

Clinical and Translational Allergy, Volume 16, Issue 4, April 2026.
ABSTRACT Background As monoclonal antibodies have proven effective in managing recalcitrant chronic rhinosinusitis with nasal polyps (CRSwNP), the concept of disease remission is evolving, underscoring the need for a comprehensive, multimodal evaluation of disease burden over time.
Francesco Giombi, Gian Marco Pace, Elena Vezzoli, Fabio Grizzi, Fabio Pasqualini, Michele Cerasuolo, Enrico Heffler, Giovanni Paoletti, Francesca Puggioni, Giuseppe Mercante, Giuseppe Spriano, Giorgio Walter Canonica, Luca Malvezzi   +12 more
wiley   +1 more source

Obtaining the recombinant fusion protein OprF-aTox of Pseudomonas aeruginosa whith protective properties

Биопрепараты: Профилактика, диагностика, лечение, 2018
Into the cells of Escherichia coli (strain BL21(DE3)) two forms of the fusion protein Pseudomonas aeruginosa containing the full length outer membrane protein F (OprF) and nontoxic form of Exotoxin A (without 106 C-terminal amino acid residues) have been
A. V. Soldatenkova, N. A. Mihailova, E. M. Zimina, E. I. Leonova, A. A. Kaloshin   +4 more
doaj  

Determining Induction Conditions for Expression of Truncated Diphtheria Toxin and Pseudomonas Exotoxin A in E. coli BL21

Novelty in Biomedicine, 2018
Background: Targeted cancer therapies have played a great role in the treatment of malignant tumors, in the recent years. Among these therapies, targeted toxin therapies such as immunotoxins, has improved the patient’s survival rate by minimizing the ...
Sahel Amoozadeh, Maryam Hemmati, Mohammad Morad Farajollahi, Neda Akbari, Parastoo Tarighi   +4 more
doaj   +1 more source

HER2-Specific Pseudomonas Exotoxin A PE25 Based Fusions: Influence of Targeting Domain on Target Binding, Toxicity, and In Vivo Biodistribution

Pharmaceutics, 2020
The human epidermal growth factor receptor 2 (HER2) is a clinically validated target for cancer therapy, and targeted therapies are often used in regimens for patients with a high HER2 expression level.
Haozhong Ding, Mohamed Altai, Wen Yin, Sarah Lindbo, Hao Liu, Javad Garousi, Tianqi Xu, Anna Orlova, Vladimir Tolmachev, Sophia Hober, Torbjörn Gräslund   +10 more
doaj   +1 more source