Results 181 to 190 of about 19,438 (226)

Staphylococcal exotoxin activation of T cells. Role of exotoxin-MHC class II binding affinity and class II isotype

The Journal of Immunology, 1991
Abstract Staphylococcal enterotoxins (SE) and toxic shock syndrome toxin-1 bind directly to class II molecules of the MHC and stimulate T cells based predominantly on the V beta segment used by the TCR. We investigated the relationship between the class II binding affinities of four of these exotoxins, SEA, SEB, SEC1, and toxic shock ...
J A, Mollick, M, Chintagumpala, R G, Cook, R R, Rich   +3 more
openaire   +2 more sources

Selective activation of murine Vβ8.2 bearing T cells by Pseudomonas exotoxin A

Cellular Immunology, 1992
We have determined that Pseudomonas aeruginosa exotoxin A (PE) can selectively stimulate the proliferation of V beta bearing T lymphocytes. Murine thymocytes were fractionated by selective agglutination with peanut agglutinin (PNA) and the PNA- thymocytes, which represent mature thymocytes, were shown to be responsive to PE stimulation.
D M, Dixon, R D, LeGrand, M L, Misfeldt
openaire   +2 more sources

Biological effects of Pseudomonas aeruginosa exotoxin A: Lymphoproliferation of T lymphocytes in athymic mice

European Journal of Epidemiology, 1988
Pseudomonas aeruginosa exotoxin A has been observed to exert modulatory effects on the immune response. The present study examines the ability of exotoxin A to induce proliferation of splenocytes from athymic nu/nu mice. We observed that exotoxin A induced the proliferation of athymic nude splenocytes which could be abrogated by heating the toxin at 70
P S, Holt, M L, Misfeldt
openaire   +2 more sources

The superantigen Pseudomonas exotoxin a requires additional functions from accessory cells for T lymphocyte proliferation

Cellular Immunology, 1991
We have examined the functions required of accessory cells (AC) for murine thymocyte proliferation induced by Pseudomonas exotoxin A (PE) and have compared these functions to those required of a known superantigen, staphylococcal enterotoxin B (SEB).
P K, Legaard, R D, LeGrand, M L, Misfeldt   +2 more
openaire   +2 more sources

A conserved mechanism of T lymphocyte stimulation by microbial exotoxins

Microbial Pathogenesis, 1989
Les enterotoxines de Staphylococcus aureus (SE) ont une activite mitogene sur les lymphocytes T. Cette stimulation des cellules T est dependante de la presence de monocytes comme cellules accessoires (AC). La liaison de SE a un antigene d'histocompatibilite de classe II meme xenogenique est suffisante pour obtenir la stimulation.
openaire   +2 more sources

Modulation of Suppressor T-Cells by Streptococcal Pyrogenic Exotoxin

1981
The V-region gene repertoire which determines the qualitative nature of an organisms’ antibody response is encoded in the genome of the immunoglobulin forming cells (B-lymphocytes) of the organism. Other cells such as thymus derived lymphocytes (T-cells) and macrophages appear to regulate or control the antibody responses of B- lymphocytes to many ...
Edgar E. Hanna, Martha L. Hale, Michael L. Misfeldt   +2 more
openaire   +1 more source

Proliferation of Immature T Cells within the Splenocytes of Athymic Mice by Pseudomonas Exotoxin A

Cellular Immunology, 1994
Pseudomonas aeruginosa exotoxin A has been shown to stimulate splenocytes from athymic nude mice. The present studies were performed to characterize the exotoxin A-responsive cells within the splenocytes of athymic nude mice. The results of these studies indicate that exotoxin A-responsive cells were represented in the nylon wool-adherent cell ...
D M, Dixon, M L, Misfeldt
openaire   +2 more sources

Triptolide Attenuates Endotoxin- and Staphylococcal Exotoxin-Induced T-Cell Proliferation and Production of Cytokines and Chemokines

Immunopharmacology and Immunotoxicology, 2005
Proinflammatory cytokines mediate the toxic effects of superantigenic staphylococcal exotoxins (SE) and bacterial lipopolysaccharide (LPS). Triptolide, an oxygenated diterpene derived from a traditional Chinese medicinal herb, Tripterygium wilfordii, inhibited SE-stimulated T-cell proliferation (by 98%) and expression of interleukin 1beta, interleukin ...
Teresa, Krakauer, Xin, Chen, O M Zack, Howard, Howard A, Young   +3 more
openaire   +2 more sources

CD8+ T-cell mediated tumor protection by Pseudomonas exotoxin fused to ovalbumin in C57BL/6 mice

Surgery, 2003
Pseudomonas exotoxin (PE) is a 66 kDa bacterial toxin that is able to bind to mammalian cells, undergo receptor mediated endocytosis, and translocate its C-terminal catalytic domain into the cytosol. We investigated whether PE could be used in vivo to deliver CD8+ T-cell epitopes to the MHC-class I antigen presentation pathway to trigger a specific ...
Juan C, Becerra, Jill F, Arthur, Gary R, Landucci, Donald N, Forthal, Charles P, Theuer   +4 more
openaire   +2 more sources

Streptococcal pyrogenic exotoxin a induces regulatory T cells via TNF-α-TNFR2 signaling

Medical Microbiology and Immunology
Bacterial superantigens are potent immune activators that trigger T cell proliferation and intensive release of cytokines, leading to toxic shock syndrome. Also, they impair host immune responses, increasing bacterial carriage and transmission. Several studies proposed that superantigens can induce regulatory T (Treg) cells, which may suppress immune ...
Chun-Hao, Lu, Jason, Ma, Ming-Chieh, Lin, Cheng-Jang, Wu, Chieh-Ying, Kuo, Chuan, Chiang-Ni, Ming-Ling, Kuo   +6 more
openaire   +2 more sources