Results 191 to 200 of about 19,438 (226)

Interleukin‐6 is essential for Staphylococcal exotoxin B‐induced T regulatory cell insufficiency in nasal polyps

Clinical & Experimental Allergy, 2009
SummaryBackground The pathogenesis of nasal polyps is still unclear. There is increasing evidence indicating that Staphylococcal aureus (S. aureus) is associated with the formation of nasal polyps, but the mechanism has not been well documented to date.Methods We stimulated cultured nasal polyps and turbinate tissues with Staphylococcal ...
G, Xu, J H, Xia, H, Zhou, C Z, Yu, Y, Zhang, K J, Zuo, J B, Shi, H B, Li   +7 more
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Acute Hepatotoxicity of Pseudomonas aeruginosa Exotoxin A in Mice Depends on T Cells and TNF

The Journal of Immunology, 1998
Abstract The most potent virulence factor of Pseudomonas aeruginosa, its exotoxin A (PEA), inhibits protein synthesis, especially in the liver, and is a weak T cell mitogen. This study was performed to correlate hepatotoxic and possible immunostimulatory features of PEA in vivo.
J, Schümann, S, Angermüller, R, Bang, M, Lohoff, G, Tiegs   +4 more
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The Human T Cell Response to Mitogenic Microbial Exotoxins

1991
Nearly every infectious pathogen has to cope with the host’s adaptive immune response. Common evasion mechanisms in this complex interaction are antigenic variations, the escape to immunologically privileged sites, or the use of immunosuppressive mechanisms.
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GM-CSF is required for the Pseudomonas exotoxin A-induced proliferation of immature T cells in athymic mice

Cellular Immunology, 1995
Previous studies have demonstrated that Pseudomonas exotoxin A stimulated the proliferation of immature T lymphocytes within the splenocytes of athymic mice. These studies were performed to determine which lymphokines were involved in the proliferation of the immature T cells.
D M, Dixon, M L, Misfeldt
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Analysis of the interaction between the bacterial superantigen streptococcal pyrogenic exotoxin A (SpeA) and the human T‐cell receptor

Molecular Microbiology, 1997
Streptococcus pyogenes that produces the bacterial superantigen streptococcal pyrogenic exotoxin A (SpeA) is associated with outbreaks of streptococcal toxic shock syndrome (STSS) in the United States and Europe. SpeA stimulates Vβ2.1, 12.2, 14.1, and 15.1‐positive T cells, and the lymphokine production from the activated T cells is believed to result
J B, Kline, C M, Collins
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Effect of Pseudomonas aeruginosa exotoxin A on CD3-induced human T-cell activation.

Immunology letters, 1998
The effect of Pseudomonas aeruginosa (PA) exotoxin A (P-ExA) on CD3-induced T-cell activation was studied on the level of T-cells (proliferation, synthesis of interleukin (IL)-2, expression of IL-2R complex, ICAM-1,2 and LFA-1 molecules), and on the level of monocytes (expression of ICAM-1,2, LFA-1 molecules, as well as FcRI and CD14 receptors).
J, Michalkiewicz, J, Stachowski, C, Barth, J, Patzer, D, Dzierzanowska, D, Runowski, K, Madalinski   +6 more
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Expression of T-cell receptor Vβ2 and type 1 helper T-cell-related cytokine mRNA in streptococcal pyrogenic exotoxin-C-activated human peripheral blood mononuclear cells

Canadian Journal of Microbiology, 1996
Streptococcal pyrogenic exotoxin type C (SPE C) is a member of the bacterial superantigens that are potent stimulants of T cells. We expressed SPE C in Escherichia coli and characterized its selective stimulation properties on human T cells bearing specific Vβ chains of T-cell receptors (TCRs).
Y, Ohara-Nemoto, M, Kaneko
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Association of T Cells and Eosinophils with Staphylococcus aureus Exotoxin a and Toxic Shock Syndrome Toxin 1 in Nasal Polyps

American Journal of Rhinology & Allergy, 2011
Background Staphylococcus aureus exotoxins (SEs) have been implicated in the pathogenesis of nasal polyps (NPs) in patients with chronic rhinosinusitis (CRS). The aim of this study was to identify the correlation between SEs and T cells in NPs. Methods After a nasal smear culture, the nasal lavage fluid and NP tissue were obtained from 30 CRS with NP ...
Seon Tae, Kim, Seung Won, Chung, Joo Hyun, Jung, Jong Su, Ha, Il Gyu, Kang   +4 more
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Deregulation of mouse antibody-forming cells by streptococcal pyrogenic exotoxin II. Modification of spleen T-cell-complemented nude mouse PFC responses

Cellular Immunology, 1976
Abstract Streptococcal pyrogenic exotoxin (SPE), a toxic protein, secreted by Group A streptococci modifies antibody responses in two ways. It suppresses the early peak plaque-forming cell (PFC) and serum antibody responses to sheep erythrocytes (SE) and it engenders a late burst of PFC detected at 12–14 days.
Hale, M L, Hanna, E E
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INVOLVEMENT OF T‐ AND B‐ LYMPHOCYTES IN THE IMMUNE RESPONSE TO THE PROTEIN EXOTOXIN AND THE LIPOPOLYSACCHARIDE ANTIGENS OF VIBRIO CHOLERAE*

Annals of the New York Academy of Sciences, 1975
The immune response at the level of individual immunocytes to the somatic lipopolysaccharide antigen derived from whole Vibrio cholerae and to the purified protein exotoxin from this organism were studied in terms of the role of T- and B-lymphocytes. By adoptive cell transfer studies with irradiated recipient mice, it was shown that normal spleen cells
Kateley, J R, Patel, C B, Friedman, H
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