Protection Efficacy of Oral Bait Probiotic Vaccine Constitutively Expressing Tetravalent Toxoids against Clostridium perfringens Exotoxins in Livestock (Rabbits) [PDF]
Vaccines, 2020 Clostridium perfringens is an opportunistic pathogen. Its main virulence factors are exotoxins, which are the etiological agents of enteritis necroticans and enterotoxemia caused in livestock (cattle, sheep, and rabbits).
Jing Bai +9 more
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Staphylococcus aureus Exotoxins and Their Detection in the Dairy Industry and Mastitis [PDF]
Toxins, 2020 Staphylococcus aureus constitutes a major food-borne pathogen, as well as one of the main causative agents of mastitis in dairy ruminants. This pathogen can produce a variety of extracellular toxins; these include the shock syndrome toxin 1 (TSST-1 ...
Ana G. Abril +6 more
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Bacterial exotoxins and the inflammasome [PDF]
Frontiers in Immunology, 2015 The inflammasomes are intracellular protein complexes that play an important role in innate immune sensing. Activation of inflammasomes leads to activation of caspase-1 and maturation and secretion of the pro-inflammatory cytokines IL-1β and IL-18.
Allison J. Greaney +2 more
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Exo-Tox: Identifying Exotoxins from secreted bacterial proteins [PDF]
BioData MiningBackground Bacterial exotoxins are secreted proteins able to affect target cells, and associated with diseases. Their accurate identification can enhance drug discovery and ensure the safety of bacteria-based medical applications.
Tanja Krueger +2 more
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Staphylococcal and Streptococcal Superantigen Exotoxins [PDF]
Clinical Microbiology Reviews, 2013 SUMMARYThis review begins with a discussion of the large family ofStaphylococcus aureusand beta-hemolytic streptococcal pyrogenic toxin T lymphocyte superantigens from structural and immunobiological perspectives. With this as background, the review then discusses the major known and possible human disease associations with superantigens, including ...
Adam R. Spaulding +5 more
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Two homologous sequences of Grp78 and HSP70 represent tumor antigens shared with streptococcal superantigens in eliciting an antitumor immune response: an immunoinformatic investigation [PDF]
Frontiers in ImmunologyBacteria-based therapies have gained increasing attention as novel immunotherapeutic approaches against tumors. Among them, bacteria producing superantigen (SAg) toxins are considered particularly effective due to their ability to induce potent ...
Paola Finotti
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Proinflammatory synergy between protease and superantigen streptococcal pyogenic exotoxins [PDF]
Infection and ImmunityStreptococcal pyogenic exotoxins (Spe proteins) secreted by Streptococcus pyogenes (group A Streptococcus, GAS) are responsible for scarlet fever and streptococcal toxic shock syndrome.
Anders F. Johnson +5 more
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Comparison of genotyping methods and toxin gene profiles of Staphylococcus aureus isolates from clinical specimens [PDF]
Genetics and Molecular Biology, 2023 Staphylococcus aureus is a frequent cause of infections worldwide. Methicillin-resistant S. aureus (MRSA) is one of the main causes of Gram-positive infections, and methicillin-susceptible strains (MSSA) primarily colonize and infect community hosts ...
Mariana Andrade-Figueiredo +3 more
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Toxins, 2022 Staphylococcus aureus is a human and animal pathogen as well as a commensal bacterium. It can be a causative agent of severe, life-threatening infections with high mortality, e.g., toxic shock syndrome, septic shock, and multi-organ failure. S.
Andreas Roetzer +5 more
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Pathogens, 2022 Bacterial exotoxins with ADP-ribosyltransferase activity can be divided into distinct clades based on their domain organization. Exotoxins from several clades are known to modify actin at Arg177; but of the 14-3-3 dependent exotoxins only Aeromonas ...
Carmen Ebenwaldner +6 more
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