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Purification of Streptococcal Pyrogenic Exotoxin A
2003Group A streptococci secrete a variety of molecules, many of which are recognized as virulence factors important in the establishment of streptococcal infections. Among these extracellular products is streptococcal pyrogenic exotoxin A (SPE A, scarlet fever toxin A, erythrogenic toxin A) (1).
M, Roggiani, P M, Schlievert
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Hyperhidrosis Treated by Botulinum A Exotoxin
Dermatologic Surgery, 1998Hyperhidrosis, or excessive sweating, can be emotionally challenging and socially and professionally disruptive, and there have been few effective treatments. Recently, botulinum toxin has been demonstrated to be an effective treatment for hyperhidrosis of the axillae and palms and for gustatory sweating.This article reviews the current treatments and ...
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Pseudomonas aeruginosaExotoxin A
New England Journal of Medicine, 1980Pseudomonas aeruginosa is an opportunistic pathogen that causes more than 100,000 infections in the United States each year. Pseudomonas infections are associated with considerable morbidity and mortality despite the use of modern antibiotics.1 Recognition of the limitations of existing therapy for pseudomonas disease has stimulated renewed interest in
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Kawasaki Disease and Staphylococcal Exotoxins
Archives of Dermatology, 1980To the Editor.— In their recent report of a possible case of Kawasaki disease, Schlossberg et al 1 discuss the possibility that a staphylococcal exotoxin, found in the patient's vaginal discharge, may have been responsible for her symptoms. The pyrogenic exotoxin that they isolated, however, lacked exfoliative activity in the rabbit and mouse.
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Bacterial Exotoxins and Sepsis
1994Researchers engaged in the study of septic shock pathogenesis generally regard this syndrome to be the consequence of detrimental endotoxin effects in the host organism. This is understandable since causal relationships are firmly established between the action of endotoxin on various inflammatory competent cells.
W. Seeger +4 more
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Pseudomonas aeruginosa exotoxin A
1997Abstract Pseudomonas aeruginosa exotoxin A (PEA, MW 66 kDa, 613 amino acids, sequence accession number: PSEETA K01397) consists of three major domains (Allured et al. 1986), as indicated in Fig. 1. The N-terminal domain la (amino acids 1-252) binds to the ai-macroglobulin receptor at the cell surface (Kounnas et al.
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