Molecular Mechanisms of Mast Cell Activation by Cholesterol-Dependent Cytolysins
Frontiers in Immunology, 2021 Mast cells are potent immune sensors of the tissue microenvironment. Within seconds of activation, they release various preformed biologically active products and initiate the process of de novo synthesis of cytokines, chemokines, and other inflammatory ...
Lubica Draberova +2 more
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Toxin Production by Aeromonas sobria in Natural Environments: River Water vs. Seawater [PDF]
, 2008 Aeromonas are water-borne pathogens. They are halotolerant, which means that they can survive in environments whose salt content corresponds to that of seawater (3.0% NaCl).
Ansaruzzaman, Mohammad +6 more
core +1 more source
Bacterial Exotoxins: General Characteristics and Mode of Action [PDF]
مجلة جامعة كركوك للعلوم الزراعيةThe idea of the harmful effects of pathogenic bacteria via toxin production has existed since ancient times. In 1872, Klebs hypothesized that "sepsins" were responsible for the formation of toxins produced by staphylococci, although he was unable to ...
Mustafa Omar
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Cells, 2022 The increasing antibiotic resistance of bacterial pathogens fosters the development of alternative, non-antibiotic treatments. Antivirulence therapy, which is neither bacteriostatic nor bactericidal, acts by depriving bacterial pathogens of their ...
Hervé Besançon +4 more
doaj +1 more source
Subinhibitory concentrations of perilla oil affect the expression of secreted virulence factor genes in Staphylococcus aureus. [PDF]
PLoS ONE, 2011 BACKGROUND: The pathogenicity of staphylococcus aureus is dependent largely upon its ability to secrete a number of virulence factors, therefore, anti-virulence strategy to combat S. aureus-mediated infections is now gaining great interest.
Jiazhang Qiu +10 more
doaj +1 more source
Intrinsic Toxin-Derived Peptides Destabilize and Inactivate
mBio, 2017 Clostridium difficile infection (CDI) is a major cause of hospital-associated, antibiotic-induced diarrhea, which is largely mediated by the production of two large multidomain clostridial toxins, TcdA and TcdB.
Jason L. Larabee +3 more
doaj +1 more source
Detection of Exotoxins and Antimicrobial Susceptibility Pattern in Clinical Pseudomonas Aeruginosa Isolates [PDF]
, 2017 Background: Pseudomonas aeruginosa is a common opportunistic pathogen that causes nosocomial infection in immunocompromised patients. Among different virulence factors, the type III secretion system (TTSS) is an important agent in virulence and ...
Deris, Fatemeh. +4 more
core +1 more source
The binding of botulinum neurotoxins to different peripheral neurons [PDF]
, 2017 Botulinum neurotoxins are the most potent toxins known. The double receptor binding modality represents one of the most significant properties of botulinum neurotoxins and largely accounts for their incredible potency and lethality.
Rossetto, O.
core +1 more source
Tailored liposomal nanotraps for the treatment of Streptococcal infections
Journal of Nanobiotechnology, 2021 Background Streptococcal infections are associated with life-threatening pneumonia and sepsis. The rise in antibiotic resistance calls for novel approaches to treat bacterial diseases. Anti-virulence strategies promote a natural way of pathogen clearance
Hervé Besançon +9 more
doaj +1 more source
Draft Genome Sequence of a Community-Associated Methicillin- Resistant Panton-Valentine Leukocidin-Positive Staphylococcus aureus Sequence Type 30 Isolate from a Pediatric Patient with a Lung Infection in Brazil [PDF]
, 2015 The sequence of methicillin-resistant Staphylococcus aureus strain B6 (sequence type 30 [ST30], spa type t433, staphylococcal chromosomal cassette mec element [SCCmec] type IVc, Panton-Valentine leukocidin [PVL] positive), isolated from a pediatric ...
Afonso de Araujo, Veronica +7 more
core +2 more sources