Results 131 to 140 of about 3,500,066 (302)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Pourquoi avons-nous besoin de connaître l’expérience de visite des visiteurs des parcs nationaux ?

open access: yesTéoros, 2006
Depuis quelques années, le mot « expérience » a été utilisé à toutes les sauces, créant une certaine  confusion quant à sa signification réelle et à son importance pour les besoins de la gestion des aires protégées.
Julianna Priskin, Daniel Gosselin
doaj  

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

open access: yesFEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin   +3 more
wiley   +1 more source

L'approche PICT pour évaluer in situ l'adaptation et la résilience de biofilms périphytiques aux substances pharmaceutiques : expérience de translocation dans un cours d'eau contaminé

open access: green, 2023
Hélène Rogue   +8 more
openalex   +1 more source

Conceptualisation du tourisme polaire : cartographier une expérience aux confins de l’imaginaire

open access: yesTéoros, 2009
Le tourisme polaire connaît un début de massification. Compte tenu des grands espaces et des ressources naturelles et culturelles relativement fragiles auxquelles il fait appel, ce tourisme nécessite des modes de gestion particuliers.
Alain A. GRENIER
doaj  

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

open access: yesFEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin   +12 more
wiley   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

open access: yesAging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey   +12 more
wiley   +1 more source

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