Results 111 to 120 of about 3,500,066 (302)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Vaccination against heartwater using in vitro attenuated Cowdria ruminantium organisms [PDF]

, 1993
Des passages successifs de Cowdria ruminantium (stock Sénégal) dans des cultures de cellules endothéliales ombilicales bovines ont produit une perte de virulence sans perte d'immunogénicité, comme il a été démontré antérieurement.
Gueye, Arona, Jongejan, Frans, Uilenberg, Gerrit, Vogel, S.W.   +3 more
core  

Contribution de la caisse de solidarité interscolaire pour l’intégration effective de l’approche par compétence : expérience et attente des acteurs de la ville de Kikwit, Province du Kwilu, RD Congo

Revue Congolaise des Sciences et Technologies
A Kikwit l'approche par compétences est théoriquement mise en œuvre, mais en pratique courante, son existence est difficile à démontrer compte tenu des enseignements toujours orientés dans l’Approche par Objectifs.
Denise Katolo Nankwaya, Samuel Bapidia Nzengu , Leyka Mukandu Basua Babintu, Augustin Tshitadi Makangu   +3 more
doaj   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

De l’E-gouvernement au gouvernement agile; Expérience du Maroc

, 2021
Abdelilah El Attar, Youssef Mazouz
openalex   +1 more source

Une expérience d'encadrement départemental en français [PDF]

, 2011
Depuis l’automne 2008, le Département de français du Cégep André-Laurendeau a mis en place des « mesures d’encadrement et de suivi des étudiants » qui permettent par différents moyens aux étudiants inscrits aux trois premiers cours de français de réussir
Poulin, Marie-Pier, Roberge, Julie, Roger, Jean-Paul   +2 more
core  

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

" Je pense que ça traite d'expérience de lecture, à voir ... " : retour sur une expérience d'annotation collaborative

, 2021
François Vignale, Guillaume Le Noé Bienvenu, Guillaume Gravier, Pascale Sébillot   +3 more
openalex   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source