Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata +13 more
wiley +1 more source
A Novel Ultrasonic Welding-Assisted Thermoplastic Root Canal Obturation Technique: An Ex Vivo Proof-of-Concept Study. [PDF]
Alshehri M +4 more
europepmc +1 more source
Le traitement de l'haemonchose et de l'oesophagostomose ovines par les agents tensio-actifs (alkylsulfates de soude) [PDF]
Daumas, Raoul, Grétillat, Simon
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Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
A simple <i>ex vivo</i> bladder infection model permits study of host-pathogen interactions in urinary tract infection. [PDF]
Köhn RM +6 more
europepmc +1 more source
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Geniposide Stabilized Atherosclerosis Plaque by Induced M2 Polarization via PPARγ Signaling Pathway [Letter]. [PDF]
Guo H, Zhao Y, Cong Z.
europepmc +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Correction: Menin inhibition suppresses castration-resistant prostate cancer and enhances chemosensitivity. [PDF]
Cherif C +17 more
europepmc +1 more source
La péripneumonie bovine : précisions sur une nouvelle voie d'immunisation. Résultats conséquences et hypothèses [PDF]
Mémery, Georges, Orue, Jean
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