Results 181 to 190 of about 114,889,184 (267)

In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans

FEBS Open Bio, EarlyView.
In vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Lynn Muller, Jana Bleher, Birgit Weinberger, Lourdes Rocamora‐Reverte   +3 more
wiley   +1 more source

CSF1R inhibition following antibody mediated demyelination has limited impact on remyelination. [PDF]

Acta Neuropathol Commun
Golden LC, Peet GC, Rodriguez RE, Jahahn NJ, Owens GP, Bennett JL, Macklin WB.   +6 more
europepmc   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

Biomechanical assessments of high-fluence corneal cross-linking with supplemental oxygen using optical coherence elastography in <i>ex vivo</i> rabbit eyes. [PDF]

J Biomed Opt
Thompson V, Beckman KA, Rajpal R, Tavakol B, Elmhurst S, Usher DB, Hill JM, Navratil T.   +7 more
europepmc   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

β-Hydroxybutyrate Maintains Energetically Demanding Neural Functions During Exogenous Glucose Deprivation. [PDF]

Cell Mol Neurobiol
Ricks RL, Nevers DS, Poulos T, Shafer TL, Dunford C, Hansen JM, Reynolds PR, Bikman BT, Parrish RR.   +8 more
europepmc   +1 more source

DE VIVO B. and AYUSO R. A. (Eds), 2015. Volume 158, Journal of Geochemical Exploration, Elsevier, November, 1-256. ISSN: 0375-6742.

, 2015
AYUSO, Robert, DE VIVO, Benedetto
core  

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

Comment on: 'Contact Pressure Under Traditional Foam and Novel Thermoplastic Elastomer Negative Pressure Wound Therapy Interfaces'. [PDF]

Wound Repair Regen
Kairinos N.
europepmc   +1 more source

DE VIVO B. and AYUSO R. A. (Eds), 2015. Volume 155, Journal of Geochemical Exploration, Elsevier, August, 1-90. ISSN: 0375-6742.

, 2015
AYUSO, Robert, DE VIVO, Benedetto
core