Results 41 to 50 of about 104,522 (119)

A range finding protocol to support design for transcriptomics experimentation: examples of in-vitro and in-vivo murine UV exposure. [PDF]

PLoS ONE, 2014
In transcriptomics research, design for experimentation by carefully considering biological, technological, practical and statistical aspects is very important, because the experimental design space is essentially limitless.
Oskar Bruning, Wendy Rodenburg, Conny T van Oostrom, Martijs J Jonker, Mark de Jong, Rob J Dekker, Han Rauwerda, Wim A Ensink, Annemieke de Vries, Timo M Breit   +9 more
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Predicting the in vivo pulmonary toxicity induced by acute exposure to poorly soluble nanomaterials by using advanced in vitro methods

Particle and Fibre Toxicology, 2018
Background Animal models remain at that time a reference tool to predict potential pulmonary adverse effects of nanomaterials in humans. However, in a context of reduction of the number of animals used in experimentation, there is a need for reliable ...
Thomas Loret, Françoise Rogerieux, Bénédicte Trouiller, Anne Braun, Christophe Egles, Ghislaine Lacroix   +5 more
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Methods for culturing retinal pigment epithelial cells: a review of current protocols and future recommendations

Journal of Tissue Engineering, 2016
The retinal pigment epithelium is an important part of the vertebrate eye, particularly in studying the causes and possible treatment of age-related macular degeneration.
Aaron H Fronk, Elizabeth Vargis
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Drosophila melanogaster: a simple system for understanding complexity

Disease Models & Mechanisms, 2019
Understanding human gene function is fundamental to understanding and treating diseases. Research using the model organism Drosophila melanogaster benefits from a wealth of molecular genetic resources and information useful for efficient in vivo ...
Stephanie E. Mohr, Norbert Perrimon
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Integrating experimentation and quantitative modeling to enhance discovery of beta amyloid (Aβ) lowering therapeutics for Alzheimer’s disease

Frontiers in Pharmacology, 2012
Drug discovery can benefit from a proactive-knowledge-attainment philosophy which strategically integrates experimentation and pharmacokinetic/pharmacodynamic (PK/PD) modeling.
Yasong eLu
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A database of chemical absorption in human skin with mechanistic modeling applications

Scientific Data
Whether from environmental and occupational hazards or from topical pharmaceuticals, the human skin comes into contact with various chemicals every day.
Jessica N. Stevens, Alyson K. Prockter, Hunter A. Fisher, Hien Tran, Marina V. Evans   +4 more
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Is animal experimentation fundamental? A experimentação animal é fundamental?

Acta Cirúrgica Brasileira, 2009
The understanding about the utilization of experimental animals in scientific research and in teaching is many times a complex issue. Special attention needs to be paid to attain the understanding by the general public of the importance of animal ...
Armando José d'Acampora, Lucas Félix Rossi, Jorge Bins Ely, Zulmar Acciolli de Vasconcellos   +3 more
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Recent molecular approaches to understanding astrocyte function in vivo

Frontiers in Cellular Neuroscience, 2013
Astrocytes are a predominant glial cell type in the nervous systems, and are becoming recognized as important mediators of normal brain function as well as neurodevelopmental, neurological, and neurodegenerative brain diseases.
David eDavila, Karine eThibault, Todd A Fiacco, Cendra eAgulhon   +3 more
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Manganese mitigates atrazine-induced oxidative stress and hepatorenal toxicity: insights from network pharmacology and in vivo experimentation

BMC Pharmacology and Toxicology
Network analysis has provided valuable insights into the mechanisms underlying the hepatoprotective effects of manganese (Mn) in rats subjected to atrazine (ATZ) intoxication. Key hub genes, including STAT3, PPARG, GSK3B, HIF1A, ESR1, START1, MTOR, PPARA,
Solomon E. Owumi, Tella T. Adedayo, Joseph Chimezie, Bayode Oluwawibe, Harieme Agbarogie, Jesutosin O. Babalola, Oludare M. Ogunyemi, Uche O. Arunsi, Moses T. Otunla, Chioma E. Irozuru, Ahmad Altayyar, Eziuche A. Ugbogu   +11 more
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Guideline Checklist for Publishing Research Papers on Animal Experimentation and Comparative Medicine in China (2024 Edition)

Shiyan dongwu yu bijiao yixue
The standardization, transparency, and completeness of research papers in animal experimentation and comparative medicine research are crucial for ensuring the credibility, reproducibility, and clinical applicability of research findings. Internationally
Editorial Board of Laboratory Animal and Comparative Medicine
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