Results 91 to 100 of about 34,807 (305)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Frequency Response Analysis of Buck-Boost Inverter

Mìkrosistemi, Elektronìka ta Akustika, 2019
The paper deals with processes analysis in inverter circuits. These processes are described by differential equations with periodical coefficients. Since control signals and voltages operating in an inverter circuit are independent theirs frequencies are
Igor Yevheniiovych Korotyeyev
doaj   +1 more source

"A Semi-group Expansion for Pricing Barrier Options" [PDF]

This paper presents a new asymptotic expansion method for pricing continuously monitoring barrier options. In particular, we develops a semi-group expansion scheme for the Cauchy-Dirichlet problem in the second-order parabolic partial differential ...
Takashi Kato, Akihiko Takahashi, Toshihiro Yamada   +2 more
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Piecewise Analytical Approximation Methods for Initial-Value Problems of Nonlinear Ordinary Differential Equations

Mathematics
Piecewise analytical solutions to scalar, nonlinear, first-order, ordinary differential equations based on the second-order Taylor series expansion of their right-hand sides that result in Riccati’s equations are presented.
Juan I. Ramos
doaj   +1 more source

Development and application of an empirical formula for the high temperature behavior of ferroelectric ceramics switched by electric field at room temperature

AIP Advances, 2017
The strain changes during temperature rise of a poled lead titanate zirconate rectangular parallelepiped switched by electric field at room temperature are obtained by integrating thermal expansion coefficients that are measured using an invar-specimen ...
Dae Won Ji, Sang-Joo Kim
doaj   +1 more source

Steady-State Analysis of Inverter Working with Varied Load

Mìkrosistemi, Elektronìka ta Akustika, 2019
The paper deals with an analysis of steady-state behaviours in inverter circuits. Transient and steady-state processes in inverter circuits are described by differential equations with periodical coefficients.
Igor Yevheniiovych Korotyeyev
doaj   +1 more source

An eigenfunction expansion associated with a two-parameter system of differential equations. I

, 1981
SynopsisTechniques from the theory of partial differential equations are employed to prove the uniform convergence of the eigenfunction expansion associated with a left definite two-parameter system of ordinary differential equations of the second order.
M. Faierman
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source