Results 111 to 120 of about 34,807 (305)

Solution of polynomial Lyapunov and Sylvester equations

, 2006
A two-variable polynomial approach to solve the one-variable polynomial Lyapunov and Sylvester equations is proposed. Lifting the problem from the one-variable to the two-variable context gives rise to associated lifted equations which live on finite ...
Peeters, Ralf, Rapisarda, Paolo
core  

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Second-Order L1 Schemes for Fractional Differential Equations

Fractal and Fractional
Difference schemes for the numerical solution of fractional differential equations rely on discretizations of the fractional derivative. In this paper, we obtain the second-order expansion formula for the L1 approximation of the Caputo fractional ...
Yuri Dimitrov, Slavi Georgiev, Radan Miryanov, Venelin Todorov   +3 more
doaj   +1 more source

Generalized multitime expansions for equations with slowly varying coefficients

International Journal of Mathematics and Mathematical Sciences, 1984
The successive terms in a uniformly valid multitime expansion of the solutions of constant coefficient differential equations containing a small parameter ϵ may be obtained without resorting to secularity conditions if the time scales ti=ϵit(i=0,1,…) are
L. E. Levine, W. C. Obi
doaj   +1 more source

An Application of Convolution Expansions to an Infinite System of Differential Equations

Journal of Differential Equations, 1995
The existence, uniqueness, and stability problems for an infinite system of nonlinear differential equations are discussed. This system describes the evolution of a discrete dynamic system with interactions. Such equations arise in many fields of physics, chemistry, and ecology.
openaire   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

"On Approximation of the Solutions to Partial Differential Equations in Finance" [PDF]

This paper proposes a general approximation method for the solutions to second-order parabolic partial differential equations (PDEs) widely used in finance through an extension of Léandre's approach(Léandre (2006,2008)) and the Bismut identiy(e.g ...
Akihiko Takahashi, Toshihiro Yamada
core  

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Accelerated numerical schemes for deterministic and stochastic partial differential equations of parabolic type

, 2013
First we consider implicit finite difference schemes on uniform grids in time and space for second order linear stochastic partial differential equations of parabolic type.
Hall, Eric Joseph
core