Results 41 to 50 of about 16,335 (216)

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Complex Contradictions as Drivers of Expansive Learning in Water Resources Co-management in the uMzimvubu Catchment

Southern African Journal of Environmental Education
The aim of this article is to understand complex contradictions which are involved in collaborative management of water resources at a catchment level in South Africa, where numerous water challenges exist including security of supply, degradation of ...
Mzukisi Kuse
doaj   +1 more source

“I See Students Differently”: Following the Lead of Maker Educators in Defining What Counts as Learning

Frontiers in Education, 2020
With the expansion of maker programs in school and out-of-school settings, investigating the connections between making and learning is important for many reasons, not least to build the evidence base needed by educators committed to its practice.
Bronwyn Bevan, Jean J. Ryoo, Aaron Vanderwerff, Karen Wilkinson, Mike Petrich   +4 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

De l’évaluation à l’autoévaluation : d’un apprentissage défensif à un apprentissage expansif

Contextes et Didactiques, 2019
Self-evaluation involves making a value judgement of oneself. It also involves accepting to reveal something about oneself. In a school context, this act questions both educational relationship spaces: the level of reception and transmission (Vieille ...
Sylvie Gruber Jost, Henri Vieille-Grosjean   +1 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

The Double Path of Expansive Learning in Complex Socio-Technical Change Processes

Outlines, 2014
The purpose of this article is to describe how expansive learning in organisations can become a resource for learning in a wider community of practice (CoP).
Monika Hackel, Michael Klebl
doaj  

Boundary learning in a gender responsive curriculum transformation in Zimbabwe: an activity theory approach

Roteiro, 2017
This paper aims to share insights of a boundary learning process in a curriculum transformation in Zimbabwe. It is based on the dialectical lenses of Cultural-Historical Activity Theory (CHAT).
Charles Chikunda, Plaxcedes Chikunda, Rafael Fonseca de Castro   +2 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source