Results 41 to 50 of about 201,985 (296)

Rethinking general education in the English upper secondary system [PDF]

, 2011
The Secretary of State for Education's recent announcement of an English Baccalaureate at 16+ has opened up a debate about the nature of general education in the English upper secondary system.
Hodgson, Ann, Spours, Ken
core   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

From contradictions to kinship: expansive learning and concept formation in the wild

Frontiers in Education
IntroductionThis article examines the Explorer Program, a culturally grounded credit-recovery pathway co-designed through the Indigenous Learning Lab at a rural high school in the United States.
Aydin Bal, Linda Orie, Levi Massey, Fred Maulson, Samantha Maki, Yrjö Engeström, Annalisa Sannino   +6 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

An interview with Yrjö Engeström and Annalisa Sannino on activity theory

Bellaterra Journal of Teaching & Learning Language & Literature, 2016
The authors interviewed professors Yrjö Engeström and Annalisa Sannino of CRADLE, University of Helsinki, in spring 2016 about activity theory.
Joan Ploettner, Eva Tresserras
doaj   +1 more source

Hypergraph Learning with Hyperedge Expansion [PDF]

, 2012
We propose a new formulation called hyperedge expansion (HE) for hypergraph learning. The HE expansion transforms the hypergraph into a directed graph on the hyperedge level. Compared to the existing works (e.g. star expansion or normalized hypergraph cut), the learning results with HE expansion would be less sensitive to the vertex distribution among ...
Li Pu, Boi Faltings
openaire   +1 more source

Proving Expected Sensitivity of Probabilistic Programs with Randomized Variable-Dependent Termination Time [PDF]

, 2019
The notion of program sensitivity (aka Lipschitz continuity) specifies that changes in the program input result in proportional changes to the program output. For probabilistic programs the notion is naturally extended to expected sensitivity. A previous
Chatterjee, Krishnendu, Deng, Yuxin, Fu, Hongfei, Wang, Peixin, Xu, Ming   +4 more
core   +4 more sources

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Restrictive and expansive policy learning – challenges and strategies for knowledge exchange in upper secondary education across the four countries of the UK [PDF]

, 2016
This article examines the challenges and possibilities for UK policy learning in relation to upper secondary education (USE) across England, Scotland, Wales and Northern Ireland (NI) within current national and global policy contexts.
Hodgson, A, Spours, K
core   +1 more source