Results 131 to 140 of about 2,911,222 (308)

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

The back-test of the Expected Shortfall and related properties

open access: yes, 2017
A dolgozat az Expected Shortfall back-tesztjét mutatja be és az ehhez kapcsolódó matematikai eszközöket. A pénzügyi kockázat területei és kockázati mértékek bemutatásra kerülnek a Bázeli Bizottsággal együtt.
Magyar, Tamás
core  

An Exploration on Z-Number and Its Properties

open access: yesMathematics
The Z-number deserves further exploration in uncertain environments to effectively address fuzziness and reliability in practical issues simultaneously.
Guanshuang Jiang   +6 more
doaj   +1 more source

Simulating Study Data to Support Expected Value of Sample Information Calculations: A Tutorial. [PDF]

open access: yesMed Decis Making, 2022
Heath A   +5 more
europepmc   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

The value of implementation and the value of information: combined and uneven development [PDF]

open access: yes
In a budget constrained healthcare system the decision to invest in strategies to improve the implementation of cost-effective technologies must be made alongside decisions regarding investment in the technologies themselves and investment in further ...
Elisabeth Fenwick   +2 more
core  

An Efficient Method for Computing Expected Value of Sample Information for Survival Data from an Ongoing Trial. [PDF]

open access: yesMed Decis Making, 2022
Vervaart M   +5 more
europepmc   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

open access: yesMolecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy   +10 more
wiley   +1 more source

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