Results 121 to 130 of about 2,951,513 (284)

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Identification of Hub Genes Involved in Tubulointerstitial Injury in Diabetic Nephropathy by Bioinformatics Analysis and Experiment Verification. [PDF]

J Immunol Res, 2022
Yang J, Peng L, Tian Y, Tang W, Peng L, Ning J, Li D, Peng Y.   +7 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Establishment and experiment verification of screw thrust model of spiral robot for granary

Shipin yu jixie
Objective： To clarify the interaction mechanism model between screw and grain in grain pile depth, and to determine the mechanical characteristics of screw of spiral robot for granary at different speeds and depths, so as to provide the design basis for ...
ZHAO Xianfeng, YIN Qiang, YU Junpeng, YANG Liu, ZHANG Yonglin   +4 more
doaj   +1 more source

NCAPG Promotes Pulmonary Artery Smooth Muscle Cell Proliferation as a Promising Therapeutic Target of Idiopathic Pulmonary Hypertension: Bioinformatics Analysis and Experiment Verification. [PDF]

Int J Mol Sci, 2022
Fu B, Li Y, Shi X, Liu P, Zhang Y, Tian H.   +5 more
europepmc   +1 more source

Verification and Reputational Concerns: An Experiment

Journal of Behavioral and Experimental Economics, 2023
openaire   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

The mechanisms of celastrol in treating papillary thyroid carcinoma based on network pharmacology and experiment verification. [PDF]

Ann Transl Med, 2021
Yi J, Tian M, Hu L, Kang N, Ma W, Zhi J, Zheng X, Ruan X, Gao M.   +8 more
europepmc   +1 more source

Report of the Guam Agricultural Experiment Station.

, 1915
Mode of access: Internet.Continued by: Annual report (Guam Agricultural Experiment Station)Continues: Guam Agricultural Experiment Station. Annual report of the Guam Agricultural Experiment Station for .
Guam Agricultural Experiment Station.
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source