Results 91 to 100 of about 170,172,984 (310)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Calibration of observational measurement of rate of responding

open access: yes, 2011
The quality of measurement systems used in almost all natural sciences other than behavior analysis is usually evaluated through calibration study rather than relying on interobserver agreement.
Klum, M   +9 more
core   +1 more source

Progressing From Identification and Functional Analysis of Precursor Behavior to Treatment of Selfinjurious Behavior [PDF]

open access: yes, 2011
This article evaluates the utility of assessing and treating severe selfinjurious behavior (SIB) based on the outcomes of a functional analysis of precursor ...
Smith, Richard G., Dracobly, Joseph D.
core   +1 more source

Numerical and Experimental Analysis of the Structural Behavior of an EPP Component

open access: yesEngineering Proceedings
The use of expanded polymeric materials is becoming increasingly widespread in the industrial sector, not only for energy absorption purposes but also for structural applications.
Carlo Sabbatini   +4 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

ASSOCIATIVE SYMMETRY BY PIGEONS AFTER FEW-EXEMPLAR TRAINING

open access: yes, 2010
The present experiment investigated whether pigeons can show associative symmetry on a two-alternative matching to-sample procedure The procedure consisted of a within subject sequence of training and testing with reinforcement and It provided (a ...
Edson M. Huziwara   +8 more
core   +1 more source

FOX DOMESTICATION: MOLECULAR MECHANISMS INVOLVED IN SELECTION FOR BEHAVIOR

open access: yesВавиловский журнал генетики и селекции, 2014
Although animal domestication has enjoyed the attention of geneticists and evolutionary biologists since Darwin’s times, the focal question about genetic basis of this process has not been duly considered.
L. N. Trut   +4 more
doaj  

The Selective Renaissance of the Experimental Analysis of Human Behavior [PDF]

open access: yesThe Behavior Analyst, 1994
Two recent articles (Dougherty, Nedelmann, & Alfred, 1993; Hyten & Reilly, 1992) have favorably appraised the growth and health of the experimental analysis of human behavior as a whole. Within the last decade alone, there has been a more than threefold increase in the percentage of human operant papers appearing in the Journal of the Experimental ...
openaire   +2 more sources

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